Fields, Gregg B - Florida Atlantic University - Department of Chemistry and Biochemistry

研究领域

Extracellular matrix biochemistry; synthetic protein design and construction; proteases of the extracellular matrix; cancer chemical biology; biomimetic biomaterials for drug delivery; tumor cell biology/signal transduction; solid-phase peptide synthesis methodology.

近期论文

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Ivano Bertini, Marco Fragai, Claudio Luchinat, Maxime Melikian, Mirco Toccafondi, Janelle L. Lauer, and Gregg B. Fields. Structural Basis for Matrix Metalloproteinase 1-Catalyzed Collagenolysis. J. Am. Chem. Soc. 134, 2100-2110 (2012). Maciej J. Stawikowski, Beatrix Aukszi, Roma Stawikowska, Mare Cudic, and Gregg B. Fields. Glycosylation modulates melanoma cell a2b1 and a3b1 integrin interactions with type IV collagen. J. Biol. Chem. 289, 21591-21604 (2014). Lillian Onwuhu-Ekpete, Lisa Track, Anna Knapinska, Lyndsay Smith, Gaurav Kaushik, Travis LaVoi, Marc Giulianotti, Richard Houghten, Gregg B. Fields, and Dmitriy Minond. Novel Pyrrolidine Diketopiperazines Selectively Inhibit Melanoma Cells Via Induction of Late Apoptosis. J. Med. Chem. 57, 1599-1608 (2014). Manishabrata Bhowmick, Roma Stawikowska, Dorota Tokmina-Roszyk, and Gregg B. Fields. Matrix Metalloproteinase Inhibition by Heterotrimeric Triple-Helical Peptide Transition State Analogs. ChemBiochem 16, 1084-1092 (2015). Linda Cerofolini, Sabrina Amar, Janelle L. Lauer, Tommaso Martelli, Marco Fragai, Claudio Luchinat, and Gregg B. Fields. Bilayer membrane modulation of membrane type 1 matrix metalloproteinase (MT1-MMP) structure and proteolytic activity. Nat. Sci. Rep., in press (2016).