个人简介

Ph.D., University of Rochester

研究领域

Organic Chemistry, RNA Biochemistry, and Medicinal Chemistry.

Bioorganic studies of olfactory molecular recognition. Mammalian pre-mRNA 3' end processing regulation by protein phosphorylation. Synthetic delivery vectors for small RNA

近期论文

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“Aldehyde recognition and discrimination by mammalian odorant receptors via functional group-specific hydration chemistry, Yadi Li, Zita Peterlin, Jianghai Ho, Tali Yarnitzky, Min Ting Liu, Merav Fichman, Masha Y. Niv, Hiroaki Matsunami, Stuart Firestein* and Kevin Ryan*, 2014, ACS Chemical Biology “New insights into the promoterless transcription of DNA coligo templates by RNA polymerase III,” Lodoe Lama, Christine I. Seidl and Kevin Ryan,* 2014 Transcription, http://dx.doi.org/10.4161/trns.27913; PMID: 24531370 “Analysis of RNA processing reactions using cell free systems: 3' end cleavage of pre-mRNA substrates in vitro,” Joseph Jablonski, Mark Clementz, Kevin Ryan and Susana T. Valente,* J Vis Exp. (JoVE), 2014 (87). doi: 10.3791/51309 "Structurally diverse low molecular weight activators of the mammalian pre-mRNA 3' cleavage reactions," Min Ting Liu, Nagaraja N. Nagre, and Kevin Ryan,* Bioorganic and Medical Chemistry, 2013 Jan 15; 22(2):834-41. doi: 10.1016/j.bmc.2013.12.006. PMID: 24373842 “Circularized synthetic oligodeoxynucleotides serve as promoterless RNA polymerase III templates for small RNA generation in human cells,” C.I. Seidl, L. Lama and K. Ryan*, 2012 Nucleic Acids Research 2012; Nucleic Acids Research (2013) 41 (4): 2552-2564. doi: 10.1093/nar/gks1334 “Circular Single-Stranded Synthetic DNA Delivery Vectors for microRNA,” C. Seidl and K. Ryan*, PLoS One, Feb. 2011 6(2): e16925. doi:10.1371/journal.pone.0016925. PMCID: PMC3040211 “Discrimination of saturated aldehydes by the rat I7 olfactory receptor,” M.D. Kurland, M.B. Newcomer, Z. Peterlin, K. Ryan, S. Firestein, and V.S. Batista*, Biochemistry, 2010, 3, 49(30):6302-4. PMCID: PMC2912408 “Molecular Shape and the Sense of Smell,” Kevin Ryan* and Xiaozhou P. Ryan, book chapter in The 2010 McGraw-Hill Yearbook of Science and Technology, 2010, 243-245. “Small-molecule activators of pre-mRNA 3’ cleavage,” Kevin Ryan*, Asya Khleborodova, Jingyi Pan, and Xiaozhou P. Ryan, RNA, 2009 15, 3, 483-492. PMCID: PMC2657006 “The Importance of Odorant Conformation to the Binding and Activation of a Representative Olfactory Receptor,” Zita Peterlin, Yadi Li, Grant Sun, Rohan Shah, Stuart Firestein, and Kevin Ryan* Chemistry and Biology, 2008 15, 12, 1317-1327. “Finishing Touches: Post-Translational Modification of Protein Factors Involved in Mammalian pre-mRNA 3’ End Formation,” Kevin Ryan* and David L.V. Bauer, Int. J. Biochem. & Cell Bio., 2008 40, 11,2384-2396. “Pre-mRNA 3’ Cleavage is Reversibly Inhibited in Vitro by Cleavage Factor Dephosphorylation,” Kevin Ryan*, RNA Biology, 2007, 4 (1) 26-33. “Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation,” Daron Barnard, Kevin Ryan, James L. Manley and Joel Richter*, Cell, 2004, 119 (5), 641-51. “Evidence that polyadenylation factor CPSF-73 is the mRNA 3' processing endonuclease,” Kevin Ryan, Olga C. Calvo and James L. Manley*, RNA, 2004, 10 (4):565-73. “Requirements of the RNA Polymerase II C-Terminal Domain for Reconstituting pre-mRNA Cleavage,” Kevin Ryan, Kanneganti G.K. Murthy, Syuzo Kaneko and James L. Manley*, Molecular and Cellular Biology, 2002, 22, 6, 1684-1692. “Phosphorylation of CPEB by Eg2 Mediates the Recruitment of CPSF into an Active Cytoplasmic Polyadenylation Complex,” Raul Mendez, Kanneganti G.K. Murthy, Kevin Ryan, James L. Manley and Joel D. Richter,* Molecular Cell, 2000, Nov; 6(5):1253-9. “A Synthetic Receptor Motif Designed for Extended Peptide Conformations,” Kevin Ryan, Leland Gershell, and W. Clark Still,* Tetrahedron, 2000, 21, 3309-3318. “Inhibition of Gene Expression in Human Cells Through Small Molecule-RNA Interactions,” Seongwoo Hwang, Natarajan Tamilarasu, Kevin Ryan, Ikramul Huq, W. Clark Still, and Tariq M. Rana,* Proceedings of the National Academy of Sciences, USA, 1999, 96, 23, 12997-13002. “Construction of Sequence-Selective Peptide Receptors from Conformationally Restricted Eta- and Theta- Amino Acids,” Kevin Ryan and W. Clark Still,* Bioorganic and Medicinal Chemistry Letters, 1999, 9, 2673-2678. “Triplex-Directed Self-Assembly of an Artificial Sliding Clamp on Duplex DNA,” Kevin Ryan and Eric T. Kool,* Chemistry And Biology, 1998, 5:59-67.