个人简介

Ph.D., Michigan State University, 1972

研究领域

Immunotherapy of cancer Regulation of the immune system Inflammatory and autoimmune diseases

My lab studies cells of the immune system such as dendritic, macrophage, T helper and T cytotoxic cells to determine how they interact to cause inflammatory and autoimmune diseases such as asthma. We also attempt to find means to activate immune cells so they selectively destroy cancer cells. Our recent focus has been on the role of vitamin D in preventing/treating asthma. We are currently focusing on rendering cancer cells highly visible or immunogenic to dendritic cells. 

近期论文

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Keating P., Munim, A. and Hartmann, J.X. (2014). Effect of vitamin D on T-helper type 9 polarized human memory cells in chronic persistent asthma. Ann Allergy Asthma Immunol 112(2):154-162. doi: 10.1016/j.anai.2013.11.015. Zhang, X.H., Keating, P., Wang, X.W., Huang, Y.H., Martin, J., Hartmann, J.X. and Liu, A. (2014) Production of functional native human interleukin-2 in tobacco chloroplasts. Mol Biotechnol 56(4):369-376. doi: 10.1007/s12033-013-9717-x. Cavallo, M.F., Kats, A.M., Chen, R., Hartmann, J.X., Pavlovic, M. (2012). A novel method for real-time, continuous, fluorescence-based analysis of anti-DNA abzyme activity in systemic lupus. Autoimmune Dis 2012:814048. doi: 10.1155/2012/814048. Pavlovic, M., Kats, A., Cavallo, M., Chen, R., Hartmann, J.X. and Shoenfeld, Y. (2010). Pathogenic and epiphenomenal anti-DNA antibodies in SLE. Autoimmune Dis 2011:462841. doi: 10.4061/2010/462841.