Ugochukwu, Ngozi - Florida Agricultural and Mechanical University

研究领域

The main thrust of our research is the use of enzymology and cutting-edge biochemical and gene technology techniques in deciphering the underlying mechanisms in the pathophysiology of chronic metabolic diseases especially diabetes, obesity, congestive heart failure and colon cancer and their unifying link in quest of non-invasive nutritional interventions for effective preventive strategies and therapies. The methodologies are multifaceted involving the ‘omics’: pharmaco/nutrigenomics; transcriptomics (examining the expression level of mRNAs using high thorough-put techniques based on DNA microarray technology); proteomics (in discovery of disease biomarkers) and metabolomics (end-products of gene expression). Integration of all the data obtained from these methodologies give a more complete picture of the status of the organism in the disease state and therefore very valuable at the molecular level. We are also currently studying the health disparities involved in the infection and mortality of HIV-AIDS patients; various Cancers, Chronic Kidney and Cardio-Metabolic Diseases in Florida Counties.

近期论文

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1. Ugochukwu, N.H. and Figgers C.L. (2007) Attenuation of plasma dyslipidemia and oxidative damage by dietary caloric restriction in streptozotocin-induced diabetic rats. Chemico-Biological Interactions 169, 32-41. 2. Mwegoha, W., Mbuya, O.S., Jain, A., Ugochukwu, N.H. and Abazinge, M.D. (2007) Use of chicken manure extract for biostimulation and enhancement of perchlorate rhizodegradation in soil and water media. Bioremediation Journal 11, 61-70. 3. Ugochukwu, N.H. and Figgers C.L. (2007) Caloric restriction inhibits up-regulation of inflammatory cytokines and TNF-α, and activates IL-10 and haptoglobin in the plasma of streptozotocin-induced diabetic rats. The Journal of Nutritional Biochemistry 18, 120-126. 4. Ugochukwu, N.H. and Figgers C.L. (2007) Dietary caloric restriction improves the redox status at the onset of diabetes in hepatocytes of streptozotocin-induced diabetic rats. Chemico-Biological Interactions 165, 45-53. 5. Ugochukwu, N.H. and Figgers C.L. (2006) Modulation of the flux patterns in carbohydrate metabolism in the livers of streptozotocin-induced diabetic rats by dietary caloric restriction. Pharmacological Research 54, 172-180. 6. Ugochukwu, N. H., Mukes, J. D. and Figgers, C.L. (2006) Ameliorative effects of dietary caloric restriction on oxidative stress and inflammation in the brain of streptozotocin-induced diabetic rats. Clinica Chimica Acta 370, 165-173. 7. Ugochukwu, N.H. and Figgers C.L. (2006) Dietary caloric restriction modifies inflammatory responses in the livers of streptozotocin-induced diabetic rats. Nutrition Research 26, 221-226. 8. Barber, K., Ugochukwu, N.H. and Figgers C.L. (2006) Dietary caloric restriction modulates antioxidant capacity and dyslipidemia in the plasma of streptozotocin-induced diabetic rats. McNair Journal 17: 8-15. 9. Ugochukwu, N. H., Bagayoko, N.D. and Antwi, M.E. (2004) The Effects of Dietary Caloric Restriction on Antioxidant Status and lipid peroxidation in Mild and Severe Streptozotocin- induced diabetic rats. Clinica Chimica Acta 348, 121 - 129.