Musa, Musiliyu - Florida Agricultural and Mechanical University

研究领域

My research interest involved synthesis and evaluation of heterocyclic compounds, mainly coumarins; including their applications in rational drug design in the area of anticancer and Anti-HIV research. Coumarins, naturally occurring benzofurans, exhibit useful and diverse biological activities. In recent years, there has been a growing interest in their synthesis and possible applications as therapeutic agents for the treatment of various diseases such as breast cancer. Currently, my research goal focused on the following: I. Design and Synthesis of Coumarin derivatives with anticancer and anti-HIV properties utilizing innovative chemical synthetic techniques. Of particular interest are the Coumarin-based selective estrogen receptor modulators (SERMs), coumarin-estrogen conjugates and coumarin analogies of HIV-1 protease inhibitor, ritonavir. II. Antiproliferative Studies using A549 and ER enriched MCF-7 breast cancer cells lines. III. Molecular Modeling studies (Docking studies) of the coumarin ligands in the determination of the relative binding affinity based upon binding energies and the conformational changes imposed on the receptor.

近期论文

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1. Musa, Musiliyu A.; Cooperwood, John S.; Khan, M. Omar F. Synthesis and antiproliferative activity of coumarin-estrogen conjugates against breast cancer cell lines (Accepted for publication, Letters in Drug Design & Discovery, Correspondence Reference number: LDDD-6-2-13, 2009) 2. Musa, Musiliyu A.; Khan, M. Omar F.; Cooperwood, John S. Synthesis and biological evaluation of coumarin-estrogen conjugates as antiproliferative agents. Abstracts of Papers, 236th ACS National Meeting, Philadelphia, PA, United States, August 17-21, 2008 (2008). 3. Musa, Musiliyu A.; Cooperwood, John S.; Khan, M. Omar F. A review of coumarin derivatives in pharmacotherapy of breast cancer, Current Medicinal Chemistry, 2008, 15(14), 2664-2679. 4. Musa Musiliyu A.; Khan M Omar F; Cooperwood John S. Medicinal Chemistry and Emerging Strategies Applied to the Development of Selective Estrogen Receptor Modulations (SERMs), Current Medicinal Chemistry, 2007; 14(11): 1249-61. 5. Kaye, Perry T.; Musa, Musiliyu A.; Nchinda, Aloysius T.; Nocanda, Xolani W. Novel Heterocyclic Analogues of the HIV-1 Protease Inhibitor, Ritonavir, Synth. Commun, 2004, 34(14), 2575-2589. 6. Kaye, Perry T.; Musa, Musiliyu A. Regioselectivity of reaction of Nitrogen and Carbon Nucleophile with coumarin derivatives, Synth. Commun. 2004, 34(18), 3409-3417.