Mateeva, Nelly - Florida Agricultural and Mechanical University

研究领域

Our research group is involved in two major research areas: 1. Macrocyclic chemistry. Includes synthesis and analytical application of macrocyclic compounds for complex formation with metal, non-metal ions and molecules. Our most current project involves design of chromo-and fluoroionophores for chiral recognition of amino acids. Chromo- and fluoroionophores include a macrocyclic part responsible for complex formation, as well as chromo- and fluorophoric part responsible for the changes in the absorption and emission properties of the molecules upon complex formation. The analysis is performed by means of UV/Vis and Fluorescence spectroscopy. 2. Design and synthesis of anti-cancer compounds incorporating coumarin, and guanine or uracil units. These compounds are expected to selectively bind the C-terminus of the Heat Shock Protein HSP90 thus inhibiting its protein folding ability. The latter is expected to selectively inhibit the growth of cancer cells.

近期论文

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1. Walker, Winter C.,Mateeva, N.N Spectrofluorimetric Determination of Aluminum in Liquid Antacids by Complexation with Morin, FAME 2008, May 8-10, 2008, Orlando, FL 2. Eaton, Teresa M., Mateeva, N.N., Quantitative Determination of Methanol in Acetone Using Gas-less GC – CCD, FAME 2008, May 8-10, 2008, Orlando, FL 3. Eaton, Teresa M., Mateeva, N.N., Determination of Vapor Pressures Using Gas Chromatography Retention Times, FAME 2008, May 8-10, 2008, Orlando, FL 4. Mateeva, Nelly N, Deiab, Sh., Redda, K.K., Aza-macrocyclic derivatives: synthesis, structure and metal ion complexation properties, FAME 2008, May 8-10, 2008, Orlando, FL 5. Mateeva, Nelly N, Macrocyclic ligands for molecular recognition of amino acids, FAME 2007 6. Mills, Chavonda J.; Mateeva, Nelly N.; Redda, Kinfe K. Synthesis of novel substituted flavonoids. Journal of Heterocyclic Chemistry (2006), 43(1), 59-64. 7. Mills, Chavonda J.; Mateeva, Nelly N.; Redda, Kinfe K. Synthesis of substituted flavonoids and evaluation of their COX-1/COX-2 inhibitory activity. Abstracts of Papers, 229th ACS National Meeting, San Diego, CA, United States, March 13-17, 2005 . 8. Mateeva, N., Winfield, L., and Redda, K., The Chemistry and Pharmacology of Tetrahydropyridines, Current Medicinal Chemistry, 12(3), (2005). 9. Mateeva, Nelly N.; Mills, Chavonda J.; Redda, Kinfe K. Inhibition of COX1/COX2 activity by substituted chalcones and flavones. Abstracts of Papers, 229th ACS National Meeting, San Diego, CA, United States, March 13-17, 2005