个人简介

Dr. Korry Barnes, a Visiting Assistant Professor of Chemistry, earned a Ph.D. in Organic Chemistry from the University of Nevada, Reno in 2014. Barnes then conducted postdoctoral studies at Georgia Tech, where he worked on marine natural products isolation and marine chemical ecology. Barnes graduated from UWF in 2010; his B.S. was in Chemistry with a concentration in Biochemistry. Recently he has undertaken research on iminosugars, heterocycloaddition chemistry and cationic intermediates, among other subjects. His findings have been published in Organic Chemistry Frontier, Tetrahedron Letters and Journal of American Chemistry. Currently, Barnes’ research interests at UWF are aimed toward the discovery of new drug leads that have the potential to address unmet challenges in medicinal chemistry. Specifically, his short-term goal is to synthesize a small library of compounds that can target gram-negative bacterial infections. Ph.D. Organic Chemistry, University of Nevada, Reno, 2014 B.S. Chemistry/Biochemistry, University of West Florida, 2010

研究领域

When not working, Barnes loves to spend time with his wife and their new baby boys, Liam and Grayson, going on walks and taking them to the river. Other hobbies include running, road cycling, snow boarding, and general physical fitness.

Research in the Barnes group takes place at the interface between the fields of organic synthesis, biology, pharmacology, and medicinal chemistry. They are involved in designing synthetic strategies that enable the efficient and selective construction of small molecules which are structurally complex, possess biologically privileged motifs, and contain known pharmacophores. To achieve these goals, they harness the power of inexpensive and commercially available starting materials, and then leverage simple but effective organic transformations to rapidly generate molecular complexity. We then assess the pharmacological activity of the libraries of small molecules we construct and explore their application toward problems of clinical importance including cancer, microbial infections, and neurological disorders. Active or “hit” compounds are then further analyzed to determine their mode of action, followed by derivatization to ultimately provide novel structures that can serve as potential drug leads. Projects in the group are designed to provide students with a broad range of expertise including reaction discovery and development, structure elucidation, pharmacological assay development/interpretation; all while exposing them to problems in complex target-directed synthesis and mechanistic analysis.

近期论文

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Barnes, K.L.; Chen, K; Catalano, V.J.; Jeffrey, C.S. “New Building Blocks for Iminosugars: A Concise Synthesis of Polyhydroxylated Nalkoxypiperidines through an Intramolecular Azepine Ring Contraction” Org. Chem. Front. 2015, 2, 497-501. Barnes, K.L.; Koster, A.; Jeffrey, C.S. “Trapping the Elusive Aza- Oxyallylic Cation: New Opportunities in HeterocycloadditionChemistry” Tett. Lett. 2014, 55, 4690-4696. Jeffrey, C.S.; Barnes, K.L.; Eickhoff, J.A.; Carson, C.R. “Generation and Reactivity of Aza-Oxyallyl Cationic Intermediates: Aza-[4+3]Cycloaddition Reactions for Heterocycle Synthesis” J. Am. Chem. Soc. 2011, 133, 7688-7691.