个人简介

Ph.D. in Biochemistry (with Prof. Myron L. Bender), Northwestern University B.S.cum laude, Chemistry, Michigan Technological University, 1966 Ph.D. (with Prof. Myron L. Bender), Biochemistry, Northwestern University, 1971

研究领域

Biochemistry

Dr. Philipp's research uses in silico and combinatorial methods in the study of protein-ligand interactions. My research uses in silico and combinatorial methods in the study of protein-ligand interactions. The work concentrates on the serine hydrolases and includes the development of oligopeptide and transition-state analog inhibitors of blood serum coagulation factors, combinatorial and molecular modeling of serine hydrolase inhibitors, including boronic acid inhibitors of thrombin and the tuberculosis beta-lactamase, and the study of the action of boronic and borinic acids as enzyme analogs.

近期论文

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A 5-methylcytosine Hotspot Responsible for the Prevalent HSD17B10 Mutation, Song-Yu Yang; Carl Dobkin; Xue-Ying He; Menfred Philipp; W. Ted Brown, Gene, Vol. 515, Issue 2, pages 380-384 February 2013. Rational Design and Characterization of D-Phe-Pro-D-Arg-Derived Direct Thrombin Inhibitors, A.C. Figueiredo, C.C. Clement, S. Zakia, J. Gingold, Manfred Philipp & Pedro J. B. Pereira PLoS One, e34354, March 2012. A Novel Mutation in the HSD17B10 Gene of a 10-year-old Boy with Refractory Epilepsy, Choreoathetosis & Learning Disability, L.H. Seaver, Xue-Ying He, Keith Abe, T. Cowan, G.M. Enns, L.Sweetman, Manfred Philipp, S. Lee, M. Malik, & Song-Yu Yang, PLoS One, Vol. 6, e27348, November 2011. Crystallization and Preliminary Crystallographic Characterization of Three Peptidic Inhibitors in Complex with α-Thrombin, by A.C. Figueiredo, C.C. Clement, M. Philipp and Pedro J.B. Pereira, (2011). Acta Crystallographica, F: Structural Biology & Crystallization Comm. Vol. F67, pp. 54–58. "Mental Retardation Linked to Mutations in the HSD17B-10 Gene Interfering with Neurosteroid and Isoleucine Metabolism," by Song-Yu Yang, Xue-Ying He, Simon E. Olpin, Vernon R. Sutton, Joe McMenamin, Manfred Philipp, Robert B. Denman, and Mazhar Malik, (2009) Proceedings of the National Academy of Sciences, 106, 14820-14824. "How Does the NIH Support Undergraduate Research?" by Manfred Philipp, CUR Quarterly - Council on Undergraduate Research, Winter 1999 "Boronic Acids as Enzyme Models: Catalysis of Oxime Formation," by Ling-Hao Niu, Bernarda Frias, Subodh Sharma, & M. Philipp, Special Publication: Royal Society of Chemistry 143, 185-188 (1994). "Z-D-Phe-Pro-methoxypropyl-boroGlycine - a Novel Inhibitor of Thrombin with High Selectivity Containing a Neutral Side Chain at the P1 Position," G. Claeson, M. Philipp, E. Agner, M.F. Skully, V.V. Kakkar, T. DeSoyza, & L.-H. Niu, Biochemical Journal 290, 309-312, (1993). "pH-Dependent Kinetics of Tight-Binding Thrombin Inhibitors," T. DeSoyza, L.-H. Niu, M. Philipp, G. Claeson, R. Metternich, Adv. in Exptl. Biology and Medicine, Volume on The Design of Synthetic Inhibitors of Thrombin, G. Claeson et al. eds., Plenum, 1993, pp. 67-77. "Can the Scanning-Tunneling Microscope be used to Sequence DNA?" by S. Lindsay, M. Philipp, & E. Wurtzel, Genetic Analysis, Techniques and Applications 8, 8-13 (1991). "Inhibition of a Monoclonal Antibody by a Specific Nitrophenyl Ester," by G. Rao & M. Philipp, Journal of Protein Chemistry 10, 117-122 (1991). "Boronic Acid-Catalyzed Hydrolyses of Salicylaldehyde Imines," by G. Rao & M. Philipp, Journal of Organic Chemistry 56, 1505-1512 (1991). "New Boronic Acid Inhibitors of Serine Hydrolases - B. cereus ß-Lactamase I," by M. Philipp, S. Maripuri, T. deSoyza, D.S. Matteson, P. K. Jesthi, & K. M. Sadhu, in Beiträge zur Wirkstofforschung, Vol. 30, pp. 33-41 (1986.) "Subtilisin and Thiolsubtilisin" by M. Philipp & M. L. Bender, in Molecular & Cellular Biochemistry 51, 5-32 (1983). "Inhibition of Subtilisin by Arylboronic Acids" by M. Philipp & S. Maripuri, in FEBS Letters, 133, 36-38 (1981). "Nonstepwise Methods in the Preparation of Building Blocks for Polynucleotide Synthesis" by H. Seliger, B. Haas, M. Holupirek, T. Knäble, G. Tödling, & M. Philipp, in Nucleic Acids Research 7, 191-202 (1980). "Preparation of Immobilized Phosphodiesterase from Calf Spleen and its Use in Oligonucleotide Analysis" by H. Seliger, E. Teufel, & M. Philipp, in Biotechnology & Bioengineering 21, 55-64 (1980). "Comparison of the Kinetic Specificity of Subtilisin & Thiol-Subtilisin Toward n-Alkyl p-Nitophenyl Esters" by M. Philipp, I.-H. Tsai, & M. L. Bender, in Biochemistry 18, 3769-3773 (1979). "Rabbit-ß-Globin mRNA Sequences Bounding a Noncoding Insert are Self-complementary" by M. Philipp, D. Ballinger, & H. Seliger, Naturwissenschaften 65, 388 (1978). "Spontaneous Phosphorylation of Nucleosides in Formamide-Ammonium Phosphate Mixtures" by M. Philipp & H. Seliger, Naturwissenschaften 64, 273 (1977).