个人简介

Postdoctoral Training, Yale University - 2010 (Chemical Biology) Ph.D., Boston College - 2007 (Organic Chemistry) B.A., Hamilton College - 2002 (Chemistry)

研究领域

Synthetic Organic Chemistry

Professor Murelli's lab is interested in developing and using the tools of chemistry and biology to meet current challenges in medicine. A major driving force behind the lab's work is the development of new synthetic methods that enable rapid access to known but underexplored small molecules. These routes are then applied to studying and understanding the target's function, and developing improved analogs that could serve as therapeutics. -

近期论文

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Lu, G., E. Lomonosova, X. Cheng, E.A. Moran, M.J. Meyers, S.F.J. Le Grice, C.J. Thomas, J.-K. Jiang, C. Meck, D.R. Hirsch, M.P. D'Erasemo, D.M. Suyabatmaz, R.P. Murelli and J.E. Tavis. "Hydroxylated tropolones inhibit hepatitis B virus replication by blocking the viral ribonuclease H activity." Antimicrobial Agents Chemotherapy 59: 1070-79. (Books and Publications: Peer Reviewed Article) 2015 D'Erasmo, M.P., W.B. Smith, A. Munoz, P. Mohandas, A.S. Au, J.J. Marineau, L.E.N. Quadri, J.E. Bradner and R.P. Murelli. "7,9-Diaryl-1,6,8-trioxaspiro[4.5]dec-3-e-2-ones: Readily Accessible and Highly Potent Anticancer Compounds." Bioorganic and Medicinal Chemistry Letters 24: 4035-38. (Books and Publications: Peer Reviewed Article) 2014 Hirsch, D.R., G.C. Cox, M.P. D'Erasmo, T. Shakya, C. Meck, N. Mohd, G.D. Wright and R.P. Murelli. "Inhibition of ANT(2")-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones." Bioorganic and Medicinal Chemistry Letters 24: 4943-47. (Books and Publications: Peer Reviewed Article) 2014 Meck, C., M.P. D' Erasmo, D.R. Hirsch and R.P. Murelli. "The Biology and Synthesis of α-hydroxytropolones." Medicinal Chemistry Communications 5: 842-52. (Books and Publications: Peer Reviewed Article) 2014 Williams, Y.D., C. Meck, N. Mohd and R.P. Murelli "Triflic Acid Mediated Rearrangements of 3-methoxy-8-oxabicyclo[3.2.1]octa-3,6-dien-2-ones: Synthesis of Methoxytropolones and Furans." Journal of Organic Chemistry 78: 11707-13. (Books and Publications: Peer Reviewed Article) 2013 Meck, C., N. Mohd and R.P. Murelli. "An oxidopyrylium cyclization/ring-opening route to polysubstituted alpha‑hydroxytropolones." Organic Letters 14: 5988-91. (Books and Publications: Peer Reviewed Article) 2012 Munoz, A. and R.P. Murelli. "Acid-mediated coupling of gamma-hydroxybutenolides and aldehydes: Synthesis of a new class of spirocyclic ketal-lactones." Tetrahedron Letters 53: 6779-81. (Books and Publications: Peer Reviewed Article) 2012 Nelson, J.W., A.G. Chamessian, P.J. McEnany, R.P. Murelli, B.I. Kazmiercak and D.A. Spiegel. "A Biosynthetic Strategy for Re-engineering the Staphylococcus Aureus Cell Wall With Non-native Small Molecules." ACS Chemical Biology 5: 1147-55. (Books and Publications: Peer Reviewed Article) 2010 Zhang, A.X., R.P. Murelli, C. Barinka, J. Michel, A. Cocleaza, W.L. Jorgensen, J. Lubkowski and D.A. Spiegel. "A Remote Arene Binding Site of Prostate Specific Membrane Antigen Revealed by Antibody-Recruiting Small Molecules." Journal of the American Chemical Society 132: 12711-16. (Books and Publications: Peer Reviewed Article) 2010 Murelli, R.P., A.X. Zhang, J. Michel, W.L. Jorgensen and D.A. Spiegel. "Chemical Control Over Immune Recognition: A Class of Antibody-Recruiting Small Molecules (ARMs) That Target Prostate Cancer." Journal of the American Chemical Society 131: 17090-92. (Books and Publications: Peer Reviewed Article) 2009 Stern, E., S.M. Jay, S.L. Demento, R.P. Murelli, M.A. Reed, T. Malinski, D.A. Spiegel, D.J. Mooney and T.M. Fahmy. "Spatiotemporal Control Over Molecular Delivery and Cellular Encapsulation From Electropolymerized Micro and Nanopatterned Surfaces." Advanced Functional Materials 19: 2888-95. (Books and Publications: Peer Reviewed Article) 2009 Murelli, R.P., S. Catalán, M.P. Gannon and M.L. Snapper. "Ruthenium-Catalyzed Enyne Cross-Metathesis-Cyclopropanation: Three Component Access to Vinyl Cyclopropanes." Tetrahedron Letters 49: 5714-17. (Books and Publications: Peer Reviewed Article) 2008 Murelli, R.P. and M.L. Snapper. "Ruthenium-Catalyzed Tandem Cross-Metathesis/Wittig Olefination: Generation of Conjugated Dienoic Esters From Terminal Olefins." Organic Letters 9: 1749-52. (Books and Publications: Peer Reviewed Article) 2007 Murelli, R.P., A.K. Cheung and M.L. Snapper. "Conformationally Restricted (+)-Cacospongionolide B Analogues: Influence on Secretory Phospholipase A2 Inhibition." Journal of Organic Chemistry 72: 1545-52. (Books and Publications: Peer Reviewed Article) 2007 Cheung, A.K., R. Murelli and M.L. Snapper. "Total Syntheses of (+)- and (-)-Cacospongionolide B, Cacospongionolide E, and Related Analogues. Preliminary Study of Structural Features Required for Phospholipase A2 Inhibition." Journal of Organic Chemistry 69: 5712-19. (Books and Publications: Peer Reviewed Article) 2004