个人简介

Ph.D., Graduate School & University Center

研究领域

Inorganic, Molecular Biophysics and Biochemistry

Magliozzo teaches biochemistry, physical biochemistry and enzymology. His expertise lies in physical biochemistry of metalloproteins and metalloenzymes, electron paramagnetic resonance spectroscopy, rapid reaction kinetics (optical stopped-flow and rapid freeze-quench methods. -

近期论文

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Zhang, L., E.M. Andersen, A. Khajo, R.S. Magliozzo and R.L. Koder. "Dynamic Factors Affecting Gaseous Ligand Binding in an Artificial Oxygen Transport Protein." Biochemistry 52: 447-55. doi: 10.1021/bi301066z. (Books and Publications: Peer Reviewed Article) 2013 Zhao, X., H.-P. Hersleth, J. Zhu, K.K. Andersson and R.S. Magliozzo. "Access channel residues Ser315 and Asp137 in Mycobacterium tuberculosis catalase-peroxidase (KatG) control peroxidatic activation of the pro-drug isoniazid" Chemical Communications (Cambridge) 49: 11650-2. doi: 10.1039/c3cc47022a. PMID: 24185282. (Books and Publications: Peer Reviewed Article) 2013 Carreira, M., R. Calvo-Sanjuán, M. Sanaú, X. Zhao, R.S. Magliozzo, I. Marzo and M. Contel. "Cytotoxic Hydrophilic Iminophosphorane Coordination Compounds of d8 Metals. Studies of their Interactions with DNA and HSA." Journal of Inorganic Biochemistry 116: 204-14. PMID:23063789. (Books and Publications: Peer Reviewed Article) 2012 Ranguelova, K., A.B. Rice, A. Khajo, M. Triquigneaux, S. Garantziotis, R.S. Magliozzo and R.P. Mason. "Formation of Reactive Sulfite-derived Free Radicals by the Activation of Human Neutrophils: An ESR Study." Free Radical Biology & Medicine 52.8: 1264-71. Epub Feb. 2. PMID: 22326772. (Books and Publications: Peer Reviewed Article) 2012 Zhang, Qi, Abdelahad Khajo, Tsunehiro Sai, Ian de Albuquerque, Richard Magliozzo and Kalle Levon. "Intramolecular transport of charge carriers in trimeric aniline upon a three-step acid doping process." Journal of Physical Chemistry A 116: 7629-35. PMID:22784005. (Books and Publications: Peer Reviewed Article) 2012 Zhao, X., A. Khajo, S. Jarrett, J. Suarez, Y. Levitsky, R.M. Burger, A.A. Jarzecki and R.S. Magliozzo. "Specific Function of the Met-Tyr-Trp Adduct Radical and Residues Arg-418 and Asp-137 in the Atypical Catalase Reaction of Catalase-Peroxidase KatG." Journal of Biological Chemistry 287: 37057-65. PMID: 22918833. (Books and Publications: Peer Reviewed Article) 2012 Khajo, A., R.A. Bryan, M. Friedman, R.M. Burger, Y. Levitsky, A. Casadevall, R.S. Magliozzo and E. Dadachova. "Protection of Melanized Cryptococcus Neoformans From Lethal Dose Gamma Irradiation Involves Changes in Melanin's Chemical Structure and Paramagnetism." PLoS One 6.9: e25092. (Books and Publications: Peer Reviewed Article) 2011 Martínez, A., J. Suárez, T. Shand, R.S. Magliozzo and R.A. Sánchez-Delgado. "Interactions of arene-Ru(II)-chloroquine Complexes of Known Antimalarial and Antitumor Activity With Human Serum Aalbumin (HSA) and Transferrin." Journal of Inorganic Biochemistry 105: 39-45. PMID: 21113330. (Books and Publications: Peer Reviewed Article) 2011 Hirota, S., N. Tanaka, I. Micetic, P. Di Muro, S. Nagao, H. Kitagishi, K. Kano, R.S. Magliozzo, J. Peisach, M. Beltramini and L. Bubacco. "Structural Basis of the Lactate-dependent Allosteric Regulation of Oxygen Binding in Arthropod Hemocyanin." Journal of Biological Chemistry April 20. [Epub ahead of print.] PMID: 20406810. (Books and Publications: Peer Reviewed Article) 2010 Zhao, X., J. Suarez, A. Khajo, S. Yu, L. Metlitsky and R.S. Magliozzo. "A Radical on the Met-Tyr-Trp Modification Required for Catalase Activity in Catalase-peroxidase Is Established by Isotopic Labeling and Site-directed Mutagenesis." Journal of the American Chemical Society 132: 8268-69. (Books and Publications: Peer Reviewed Article) 2010 Colangeli, R., A. Haq, V.L. Arcus, E. Summers, R.S. Magliozzo, A. McBride, A.K. Mitra, M. Radjainia, A. Khajo, W.R. Jacobs Jr., P. Salgame and D. Alland. "The Multifunctional Histone-like Protein Lsr2 Protects Mycobacteria Against Reactive Oxygen Intermediates." Proceeding of the National Academy of Sciences USA 106.11, March 17: 4414-18. Epub 2009 Feb. 23. PMID: 19237572. (Books and Publications: Peer Reviewed Article) 2009 Suarez, J., K. Ranguelova, A.A. Jarzecki, J. Manzerova, V. Krymov, X. Zhao, S. Yu, L. Metlitsky, G.J. Gerfen and R.S. Magliozzo. "An Oxyferrous Heme/protein-based Radical Intermediate Is Catalytically Competent in the Catalase Reaction of Mycobacterium tuberculosis catalase-peroxidase (KatG)." Journal of Biological Chemistry 284.11, March 13 :7017-29. Epub 2009 Jan. 12. PMID: 19139099. (Books and Publications: Peer Reviewed Article) 2009 Suarez, J., K. Ranguelova, J.P. Schelvis and R.S. Magliozzo. "Antibiotic Resistance in Mycobacterium Tuberculosis: Peroxidase Intermediate Bypass Causes Poor Isoniazid Activation by the S315G Mutant of M. tuberculosis catalase-peroxidase (KatG)." Journal of Biological Chemistry 284.24, June 12: 16146-55. Epub 2009 April 9. PMID: 19363028. (Books and Publications: Peer Reviewed Article) 2009 Zhao, X., S. Yu, K. Ranguelova, J. Suarez, L. Metlitsky, J.P. Schelvis and R.S. Magliozzo. "Role of the Oxyferrous Heme Intermediate and Distal Side Adduct Radical in the Catalase Activity of Mycobacterium tuberculosis KatG Revealed by the W107F Mutant." Journal of Biological Chemistry 284.11, March 13: 7030-37. (Books and Publications: Peer Reviewed Article) 2009 Hirota, S., T. Kawahara, M. Beltramini, P. Di Muro, R.S. Magliozzo, J. Peisach, L.S. Powers, N. Tanaka, S. Nagao and L. Bubacco. "Molecular Basis of the Bohr Effect in Arthropod Hemocyanin." Journal of Biological Chemistry 283.46, Nov. 14: 31941-48. Epub 2008 Aug. 25. (Books and Publications: Peer Reviewed Article) 2008 Ranguelova, K., J. Suarez, L. Metlitsky, S. Yu, S.Z. Brejt, S.Z. Brejt, L. Zhao, J.P. Schelvis and R.S. Magliozzo. "Impact of Distal Side Water and Residue 315 on Ligand Binding to Ferric Mycobacterium tuberculosis catalase-peroxidase (KatG)." Biochemistry 47.47, Nov. 25: 12583-92. PMID: 18956888. (Books and Publications: Peer Reviewed Article) 2008 Ranguelova, K., J. Suarez, R.S. Magliozzo and R.P. Mason. "Spin Trapping Investigation of Peroxide- and Isoniazid-induced Radicals in Mycobacterium tuberculosis catalase-peroxidase." Biochemistry 47.43, Oct. 28: 11377-85. Epub 2008 Oct 2. PMID: 18831539. (Books and Publications: Peer Reviewed Article) 2008 Kapetanaki, S.M., X. Zhao, S. Yu, R.S. Magliozzo and J.P.M. Schelvis. "Modification of the Active Site of Mycobacterium tuberculosis KatG After Disruption of the Met-Tyr-Trp Cross-linked Adduct." Journal of Inorganic Biochemistry 101.3: 422-33. (Books and Publications: Peer Reviewed Article) 2007 Ouellet, H, K. Ranguelova, M. Labarre, J.B. Wittenberg, B.A. Wittenberg, R.S. Magliozzo and M. Guertin. "Reaction of Mycobacterium tuberculosis Truncated Hemoglobin O With Gydrogen Peroxide: Evidence for Peroxidatic Activity and Formation of Protein-based Radicals." Journal of Biological Chemistry 282: 7491-503. (Books and Publications: Peer Reviewed Article) 2007 Ranguelova, Kalina, Stefania Girotto, Gary J. Gerfen, Shengwei Yu, Javier Suarez, Leonid Metlitsky and Richard S. Magliozzo. "Radical Sites in Mycobacterium tuberculosis KatG Identified Using Electron Paramagnetic Resonance Spectroscopy, the Three-dimensional Crystal Structure, and Electron Transfer Couplings." Journal of Biological Chemistry 282: 6255-64. (Books and Publications: Peer Reviewed Article) 2007