何广卫 - 安徽中医药大学

个人简介

现任合肥医工医药有限公司董事长兼总经理，安徽省药物再创新工程技术研究中心主任，

研究领域

（1）创新药物研究与开发；（2）缓控释制剂技术的研究与开发；（3）药物新剂型与新制剂的研究；（4）药物分析研究。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

（1）靳璐, 姜向敏, 何广卫, 徐文婷, 龚国清, 徐云根. 4(6)-{2-[4-(2,3,4-三甲氧基苄基)哌嗪-1-基]-2-氧代乙氧基}芳甲酰胍类化合物的合成及其Na＋/H＋交换器1抑制活性. 有机化学, 2012, 32, 326-332. （2）Xiao-Zhi Yang, Wen-Hui Yang, Yun-Gen Xu, Xiao-Juan Diao, Guang-Wei He, Guo-Qing Gong. Synthesis and antithrombotic evaluation of novel dabigatran prodrugs containing a cleavable moiety with anti-platelet activity[J]. European Journal of Medicinal Chemistry, 2012，57:21-28. （3）Yun- Zhan Li, Guo-Qing Gong, Wei-Hui Yang, Xin-Hui Wang, Mei-Ling Jiang, Yi Zhou, Xiao-Zhi Yang, Yun-Gen Xu, Guang-Wei He. Antithrombotic activity of HY023016, a novel Dabigatran prodrug evaluated in animal thrombosis models[J]. Thrombosis Research, 2013, 131: 425-435. （4）Xiao-Zhi Yang , Xiao-Juan Diao , Wen-Hui Yang, Feng Li, Guang-Wei He, Guo-Qing Gong ,Yun-Gen Xu.Design, synthesis and antithrombotic evaluation of novel dabigatran prodrugs containing methyl ferulate[J]. Bioorganic & Medicinal Chemistry Letters. 2013, 23:2089-2092. （5）李丰, 吴强, 张强, 李家明, 何广卫. 非布司他主要杂质的合成与结构鉴定[J]. 安徽医药, 2012, 16(11):1583-1584. （6）吴吉洋, 高方圆, 叶晓岚, 刘桦, 范国荣, 何广卫. 创新药物川阿格雷及其拼合分子阿魏酸和川芎嗪的质谱裂解规律[J].第二军医大学, 2012, 33（7）：755-758. （7）Qihua Zhu, Xuyan Wang, Zhaoxing Chu , Guangwei He , Guangping Dong, Yungen Xu. Design, synthesis and biological evaluation of novel imidazo[4,5-c]- pyridinecarboxa- mide derivatives as PARP-1 inhibitor[J]. Bioorganic & Medicinal Chemistry Letter, 2013, 23:1993-1996. （8）王梦迪, 何广卫. 靶向递药系统白蛋白纳米粒的研究进展[J]. 安徽医药, 2013, 17（10）:1649-1651. （9）何广卫, 苏峰, 许国琴, 许慧雷. 富马酸喹硫平骨架缓释片的研发[J]. 广州化工, 2014, 42（13）:257-261. （10）何广卫, 吴莹, 苏峰, 郭勃. 正交设计优化克林霉素磷酸酯阴道缓释片处方[J]. 广州化工, 2014, 42（14）：258-261. （11）许国琴, 苏峰, 何广卫. 羟丙甲纤维素在药物制剂中的研究进展[J]. 广州化工, 2014, 42（4）：5-8. （12）Weirong Fang, JieWei, Dan Han , Xi Chen, Guangwei He, QiangWu, Shaoxing Chu, Yunman Li. MC-002 exhibits positive effects against platelets aggregation and endothelial dysfunction through thromboxane A2 inhibition[J]. 2014, 133: 610-615. （13）Qiong Jie, Nandani Darshika Kodithuwakku, Xin Yuan, Guangwei He, Meiling Chen, Shuhong Xu, Yulin Wu. Anti-allergic and anti-inflammatory properties of a potent histamine H1 receptor antagonist, desloratadine citrate disodium injection, and its anti-inflammatory mechanism on EA.hy926 endothelial cells[J]. European Journal of Pharmacology, 2015, 754: 1-10. （14）Yi Zhou , Jinru Huang, Wei He, Wenxiang Fan, Weirong Fang, Guangwei He, Qiang Wu, Shaoxing Chu, Yunman Li. N2 ameliorates neural injury during experimental ischemic stroke via the regulation of thromboxane A2 production[J]. 2014, 124: 458-465. （15）Jinru Huang, Nandani Darshika Kodithuwakku, Wei He, Yi Zhou, Wenxiang Fan,Weirong Fang, Guangwei He , Qiang Wu, Shaoxing Chu , Yunman Li . The neuroprotective effect of a novel agent N2 on rat cerebral ischemia associated with the activation of PI3K/Akt signaling pathway[J]. Neuropharmacology, 2015, 95: 12-21.