个人简介

Ph.D. in Chemical Engineering, University of Delaware; Postdoc, Harvard University

研究领域

Organic Chemistry

Professor Lazaridis 's research is in the area of Theoretical and Computational Biophysical Chemistry, which aims to understand how biological systems work in terms of the fundamental laws of Physics and Chemistry. Biomolecules, such as proteins and nucleic acids, have well defined conformations which often change in the course of their function. Our goal is to understand the forces that operate within and between biomolecules and develop quantitative mathematical models for their energy as a function of conformation.

近期论文

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Lipkin R.B., Lazaridis T. "Implicit Membrane Investigation of the Stability of Antimicrobial Peptide beta-barrels and arcs", J Mem Biol, on the web (link) Brice A., Lazaridis T. "Structure and Dynamics of a Fusion Peptide Helical Hairpin on the Membrane Surface: Comparison of Molecular Simulations and NMR", J. Phys. Chem. B, 118:4461-70 (2014) (link) Lazaridis T., Versace R. "The treatment of solvent in multiscale biophysical modeling", Isr. J. Chem., 54:1074-83 (2014) (link) Lazaridis T., Leveritt JM, PeBenito L. "Implicit membrane treatment of buried charged groups. Application to peptide translocation across lipid bilayers", BBA Biomembranes, 1838:2149-59 (2014) (link) Prieto L., He Y., Lazaridis T. "Protein arcs may form stable pores in membranes", Biophys J, 106:154-161 (2014) (link) Rahaman A., Lazaridis, T. "A thermodynamic approach to alamethicin pore formation", BBA Biomembranes 1838:98 (2014) (link) Erratum: link He Y., Lazaridis, T. "Activity Determinants of Helical Antimicrobial Peptides: A Large-scale Computational Study", PLOS One, 8(6): e66440 (2013) (link) He Y., Prieto L., Lazaridis, T. "Modeling Peptide Binding To Anionic Membrane Pores", J Comp Chem, 34:1463-75 (2013) (link) Lazaridis, T., He Y., Prieto L. "Membrane interactions and pore formation by the antimicrobial peptide protegrin", Biophysical J, 104:633-42 (2013) (link) Zhan H., Lazaridis, T. "Inclusion of Lateral Pressure/Curvature Stress Effects in Implicit Membrane Models", Biophysical J, 104:643-54 (2013) (link) Yuzlenko O., Lazaridis, T. "Membrane protein native state discrimination by implicit membrane models", J Comp Chem, 34:731-8 (2013) (link) Lazaridis, T. "The hydrophobic effect", in Encyclopedia of Life Sciences, Wiley, (2013) (link) Mihajlovic, M., Lazaridis, T. "Charge Distribution and Imperfect Amphipathicity Affect Pore Formation by Antimicrobial Peptides", BBA-Biomembranes , 1818:1274-83 (2012) (link) Lazaridis, T. "Ligand and Receptor Conformational Energies, in Protein-ligand interactions (Gohlke, H., Ed.), Wiley (2012) Li, Z., Lazaridis, T. "Computing the thermodynamic contributions of interfacial water", Methods in Molecular Biology, 819:393-404 (2012) (link) Zhan H., Lazaridis, T. "Influence of the membrane dipole potential on peptide binding to lipid bilayers", Biophys Chem, 161:1-7 (2012) (link) Yuzlenko O., Lazaridis, T. "Interactions between Ionizable Amino Acid Side Chains at a Lipid Bilayer-Water Interface", J Phys Chem B, 115:13674-84 (2011) (link) Madeo J., Mihajlovic M., Lazaridis T., Gunner M.R. "Slow Dissociation of a Charged Ligand: Analysis of the Primary Quinone QA Site of Photosynthetic Bacterial Reaction Centers", J Am Chem Soc, 133:17375-85 (2011) (link) Ramos J., Lazaridis, T. "Computational analysis of residue contributions to coiled-coil topology", Protein Science, 20:1845-55 (2011) (link) Prieto L., Lazaridis, T. "Computational studies of colicin insertion into membranes: The closed state", Proteins, 79:126-141 (2011) (link)