滕衍斌 - 安徽医科大学 - 生命科学学院

个人简介

2001年至2005年就读于安徽大学生命科学学院，获理学学士学位。2010年毕业于中国科学技术大学生命科学学院生化分子生物学专业，获哲学博士学位（PHD）。2011年至2015年先后在美国康奈尔大学Weill研究所和兽医学院进行博士后研究工作。2015年通过人才引进计划进入安徽医科大学生物学教研室工作。

研究领域

真核翻译起始因子eIF-5A及其Hypusine化修饰的分子机理研究。噬肺军团菌中组氨酸酸性磷酸酶LpMapA的底物特异性研究。生物毒素及小肽类药物的开发与应用。

近期论文

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Teng YB, Jing H, Aramsangtienchai P, He B, Khan S, Hu J, Lin H, Hao Q. Efficient Demyristoylase Activity of SIRT2 Revealed by Kinetic and Structural Studies. SCIENTIFIC REPORTS Sci Rep. 2015 Feb 23;5:8529. doi: 10.1038/srep08529. Hsu F, Luo X, Qiu J, Teng YB, Jin J, Smolka MB, Luo ZQ, Mao Y. The Legionella effector SidC defines a unique family of ubiquitin ligases important for bacterial phagosomal remodeling. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10538-43. Mu Y, Lian FM, Teng YB, Ao J, Jiang YL, He YX, Chen Y, Zhou CZ, Chen X. The N-terminal β-sheet of peroxiredoxin 4 in the large yellow croaker Pseudosciaena crocea is involved in its biological functions. PLoS One. 2013;8(2):e57061. Pu YG, Jiang YL, Ye XD, Ma XX, Guo PC, Lian FM, Teng YB, Chen Y, Zhou CZ. Crystal structures and putative interface of Saccharomyces cerevisiae mitochondrial matrix proteins Mmf1 and Mam33. J Struct Biol. 2011 Sep;175(3):469-74. Zhang X, Teng YB, Liu JP, He YX, Zhou K, Chen YX, Zhou CZ. Structural insights into the catalytic mechanism of the yeast pyridoxal 5-phosphate synthase Snz1. Biochem J. 2010; 432(3):445-50. Zhao MX, Jiang YL, He YX, Chen YF, Teng YB, Chen Y, Zhang CC, Zhou CZ. Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate. Proc Natl Acad Sci U S A. 2010 Jul 13; 107(28):12487-92. Hu C, Zhang X, Teng YB, Hu HX, Li WF. Structure of autophagy-related protein Atg8 from the silkworm Bombyx mori. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Jul 1; 66(Pt 7):787-90. Li WF, Yu J, Ma XX,Teng YB, Luo M, Tang YJ, Zhou CZ. Structural basis for the different activities of yeast Grx1 and Grx2. Biochim Biophys Acta. 2010 Jul; 1804(7):1542-7. Zhang NN, He YX, Li WF, Teng YB, Yu J, Chen Y, Zhou CZ. Crystal structures of holo and Cu-deficient Cu/Zn-SOD from the silkworm Bombyx mori and the implications in amyotrophic lateral sclerosis. Proteins. 2010 Jun; 78(8):1999-2004. He YX, Huang L, Xue Y, Fei X, Teng YB, Rubin-Pitel SB, Zhao H, Zhou CZ. Crystal structure and computational analyses provide insights into the catalytic mechanism of 2, 4-diacetylphloroglucinol hydrolase PhlG from Pseudomonas fluorescens. J Biol Chem. 2010 Feb 12; 285(7):4603-11. Teng YB, Jiang YL, He YX, He WW, Lian FM, Chen Y, Zhou CZ. Structural insights into the substrate tunnel of Saccharomyces cerevisiae carbonic anhydrase Nce103. BMC Struct Biol. 2009 Oct 24; 9:67. Teng YB, Ma XX, He YX, Jiang YL, Du J, Xiang C, Chen Y, Zhou CZ. Crystal structure of Arabidopsis translation initiation factor eIF-5A2. Proteins. 2009 Nov 15; 77(3):736-40. Wang S, He YX, Bao R,Teng YB, Ye BP, Zhou CZ. Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of hypothetical protein SCO4226 from Streptomyces coelicolor A3 (2). Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008 Sep 1; 64(Pt 9):847-50. Teng YB, Lian FM, Jiang YL, He YX, Zhang X, Xu TT, Chen YX and Zhou CZ. Crystal structure of Sachomyces Cerevisae deoxyhypusine synthase Dys1 and the predictable complex model with its substrate translation initiation factor eIF-5A. (In preparation)