个人简介

Ph.D., Wesleyan University

研究领域

Bioorganic Chemistry and Biochemistry

Design, synthesis and evaluation of tight-binding inhibitors of clinically important enzyme targets using a combination of rational and combinatorial approaches, enzyme kinetics and molecular modeling.

近期论文

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Hsin-Pin Ho, Pratikkumar Rathod, Marissa Louis, Christine K. Tada, Sherida Rahaman, Kevin J. Mark, Jin Leng, Dibyendu Dana, Sanjai Kumar, Mathias Lichterfeld, Emmanuel J. Chang “Studies on Quantitative Phosphopeptide Analysis by MALDI Mass Spectrometry Without Label, Chromatography or Calibration Curves” Rapid Communications in Mass Spectrometry 2014, 28(24):2681-9, [Pubmed] [Full Text] Dibyendu Dana, Shatarupa De, Pratikkumar Rathod, Anibal R. Davalos, Daniel A. Novoa, Suneeta Paroly, Viviana M. Torres, Nisar Afzal, Ravi S. Lankalapalli, Susan A. Rotenberg, Emmanuel J. Chang, Gopal Subramaniam, Sanjai Kumar "Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach" Chemical Communications (Camb) 2014, 50(74):10875-8, DOI: 10.1039/C4CC04037F [Pubmed] [Full Text] Ivone Gomes, Dipendra K. Aryal, Jonathan H. Wardman, Achla Gupta, Khatuna Gagnidze, Ramona M. Rodriguiz, Sanjai Kumar, William C. Wetsel, John E. Pintar, Lloyd D. Fricker and Lakshmi A. Devi "GPR171 is a Hypothalamic G Protein-Coupled Receptor for BigLEN, a Neuropeptide involved in Feeding” Proceedings of the National Academy of Sciences (PNAS) USA, 2013, 110(40), 16211–16216, doi:10.1073/pnas.1312938110 [Pubmed] [Full Text] Tirtha K. Das, Dibyendu Dana, Suneeta S. Paroly, Senthil K. Perumal, Satyakam Singh, Hugo Jhun, Jay Pendse, Ross L. Cagan, Tanaji T. Talele, Sanjai Kumar “Centrosomal Kinase Nek2 Cooperates With Oncogenic Pathways To Promote Metastasis” Oncogenesis, 2013, 2, e69; doi:10.1038/oncsis.2013.34 [PubMed] [Full Text] Dibyendu Dana, Anibal R. Davalos, Shatarupa De, Pratikkumar Rathod, Ranjith K. Gamage, Juliana Huestis, Nisar Afzal, Yuriy Zavlanov, Suneeta S. Paroly, Susan A. Rotenberg, Gopal Subramaniam, Kevin J. Mark, Emmanuel J. Chang, Sanjai Kumar “Development of Cell-Active Non-peptidyl Inhibitors of Cysteine Cathepsins” Bioorganic and Medicinal Chemistry, 2013, 21, 2975-87 [PubMed] | [Full Text] Dibyendu Dana, Anibal R. Davalos, Gopal Subramaniam, Nisar Afzal, William H. Hersh, Sanjai Kumar “A Base-Controlled Regioselective Synthesis of Allyl and Vinyl Phenyl Sulfones” Tetrahedron Letters, 2013, 54, 2717–2721 [Full Text] Bhargav Patel, Ramalingam Krishnan, Nikhil Khadtare, Amartya Basu, Payal Arora, K. R. Gurukumar, Aaditya Bhatta, Maulik R. Patelc, Dibyendu Dana, Sanjai Kumar, Neerja Kaushik-Basu, Tanaji T. Talele “Design and synthesis of L- and D-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase” Bioorganic and Medicinal Chemistry, 2013, 21, 3262-71 [PubMed] | [Full Text] Dibyendu Dana, Tirtha Kamal Das, Ish Kumar, Anibal Davalos Morinigo, Kevin J Mark, Daryl Ramai, Emmanuel J. Chang, Tanaji T. Talele, Sanjai Kumar “Design, Synthesis and Evaluation of 2-(Arylsulfonyl)oxiranes As Cell Permeable Covalent Inhibitors of Protein Tyrosine Phosphatases” Chemical Biology and Drug Design, 2012, 80, 489–499 [PubMed] | [Full Text] | [Our Cover Page] Dibyendu Dana & Sanjai Kumar “Covalent Inhibitors of Protein Tyrosine Phosphatases” Chemistry & Biology Interface, 2012, 2, 1, 1-11 [Full Text] Sijiu Liu, Bo Zhou, Heyi Yang, Yantao He, Zhongxin Jiang, Sanjai Kumar, Lily Wu, and Zhong-Yin Zhang “Aryl Vinyl Sulfonates and Sulfones as Active Site-Directed and Mechanism-Based Probes for Protein Tyrosine Phosphatases” Journal of the American Chemical Society, 2008, 130, 8251-8260 [PubMed] | [Full Text] Jung Hwan Lee, Sanjai Kumar, and David S. Lawrence “Stepwise Combinatorial Evolution of Akt Bisubstrate Inhibitors” ChemBioChem, 2008, 9, 507-509 [PubMed] | [Full Text] Zhaohua Dai, Natalya G. Dulyaninova, Sanjai Kumar, Anne R. Bresnick, and David S Lawrence “Visual Snapshots of Intracellular Kinase Activity at the Onset of Mitosis” Chemistry & Biology, 2007, 14(11), 1254-1260 [PubMed] | [Full Text] Fubo Liang, Sanjai Kumar, and Zhong-Yin Zhang, “Proteomic Approaches to studying Protein Tyrosine Phosphatases” Molecular BioSystems, 2007, 3(5), 308-316 [PubMed] | [Full Text] Sheng Zhang, Lan Chen, Sanjai Kumar, Li Wu, David S Lawrence, and Zhong-Yin Zhang “An Affinity-Based Fluorescence Polarization Assay for Protein Tyrosine Phosphatases” Methods, 2007, 42(3), 261-267 [PubMed] | [Full Text] Sanjai Kumar, Bo Zhou, Fubo Liang, Heyi Yang, Wei-Qing Wang and Zhong-Yin Zhang “Global Analysis of Protein Tyrosine Phosphatase Activity with Ultra-Sensitive Fluorescent Probes” The Journal of Proteome Research, 2006, 5, 1898-1905 Sanjai Kumar, Fubo Liang, David S. Lawrence, and Zhong-Yin Zhang “Small Molecule Approaches to Studying Protein Tyrosine Phosphatases” Methods, 2005, 35, 9-21 [PubMed] | [Full Text] Sanjai Kumar, S. A. Adediran, Michiyoshi Nukaga, & Rex F. Pratt “Kinetics of turnover of cefotaxime by the Enterobacter cloacae P99 and GCl beta-lactamases: two free enzyme forms of the P99 beta-lactamase detected by a combination of pre- and post-steady state kinetics” Biochemistry, 2004, 9(43), 2664-72 [PubMed] | [Full Text] Michiyoshi Nukaga, Sanjai Kumar, Kayoko Nukaga, Rex. F. Pratt & James. R. Knox “Hydrolysis of Third-Generation Cephalosporins by Class C beta-Lactamases: Structure of a Transition-State Analog of Cefotaxime in Wild-type and Extended-Spectrum Enzymes” The Journal of Biological Chemistry, 2004, 279(10), 9344-52 [PubMed] | [Full Text] Sanjai Kumar, Bo Zhou, Fubo Liang, Wei-Qing Wang, Zhonghui Huang, and Zhong-Yin Zhang “Activity-Based Probes for Protein Tyrosine Phosphatases” Proceedings of the National Academy of Sciences (PNAS) USA, 2004, 101(21), 7943-48 [PubMed] | [Full Text] Sanjai Kumar, Andre L. Pearson & Rex F. Pratt “Design, synthesis, and evaluation of alpha-ketoheterocycles as class C beta-lactamase inhibitors” Bioorganic and Medicinal Chemistry, 2001, 9, 2035-44 [PubMed] | [Full Text]