个人简介

Ph.D., Columbia University

研究领域

Molecular Biophysics

Dr. Khayat's research goal is to understand the life-cycle of particular DNA viruses at an atomic resolution. In particular we seek to characterize the mechanisms by which these viruses identify their hosts, acquire entry into the cell, modify the cellular cytoskeleton, deliver their genomes to the nucleus, replicate, assemble and egress from the cell. The group uses a combination of biochemistry, biophysics, X-ray crystallography and cryo-electron microscopy to address these topics. - See more at: http://www.gc.cuny.edu/Page-Elements/Academics-Research-Centers-Initiatives/Doctoral-Programs/Chemistry/Faculty-Bios/Reza-Khayat#sthash.QjuBGI0L.dpuf

近期论文

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Murin CD, Julien JP, Sok D, Stanfield RL, Khayat R, Cupo A, Moore JP, Burton DR, Wilson IA, Ward AB. Structure of 2G12 Fab2 in Complex with Soluble and Fully Glycosylated HIV-1 Env by Negative-Stain Single Particle Electron Microscopy. J. Virology 2014 Sep 1;88(17):10177-88. Veesler D, Khayat R, Krishnamurthy S, Snijder J, Huang RK, Heck AJ, Anand GS, Johnson JE. Architecture of a dsDNA Viral Capsid in Complex with Its Maturation Protease. Structure. 2014 Feb 4;22(2):230-7. Klasse PJ, Depetris RS, Pejchal R, Julien JP, Khayat R, Lee JH, Marozsan AJ, Cupo A, Cocco N, Korzun J, Yasmeen A, Ward AB, Wilson IA, Sanders RW, Moore JP. Influences on trimerization and aggregation of soluble, cleaved HIV-1 SOSIP envelope glycoprotein. J. Virology 2013 Jul 3. Khayat R, Lee JH, Julien JP, Cupo A, Klasse PJ, Sanders RW, Moore JP, Wilson IA, Ward AB. Structural characterization of cleaved, soluble human immunodeficiency virus type-1 envelope glycoprotein trimers. J. Virology 2013 Jul 3. Kong L, Lee JH, Doores KJ, Murin CD, Julien JP, McBride R, Liu Y, Marozsan A, Cupo A, Klasse PJ, Hoffenberg S, Caulfield M, King CR, Hua Y, Le KM, Khayat R, Deller MC, Clayton T, Tien H, Feizi T, Sanders RW, Paulson JC, Moore JP, Stanfield RL, Burton DR, Ward AB, Wilson IA. Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120. Nat. Struct. Mol. Biol. 2013 Jul;20(7):796-803. Julien JP, Sok D, Khayat R, Lee JH, Doores KJ, Walker LM, Ramos A, Diwanji DC, Pejchal R, Cupo A, Katpally U, Depetris RS, Stanfield RL, McBride R, Marozsan AJ, Paulson JC, Sanders RW, Moore JP, Burton DR, Poignard P, Ward AB, Wilson IA. Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans. PLoS Pathogens 2013 May;9(5):e1003342. Ekiert DC, Kashyap AK, Steel J, Rubrum A, Bhabha G, Khayat R, Lee JH, Dillon MA, O'Neil RE, Faynboym AM, Horowitz M, Horowitz L, Ward AB, Palese P, Webby R, Lerner RA, Bhatt RR, Wilson IA. Cross-neutralization of influenza A viruses mediated by a single antibody loop. Nature. 2012 Sep 27;489(7417):526-32. Schneemann A, Speir JA, Tan GS, Khayat R, Ekiert DC, Matsuoka Y, Wilson IA. A virus-like particle that elicits cross-reactive antibodies to the conserved stem of influenza virus hemagglutinin. J Virology. 2012 Nov;86(21):11686-97. Dreyfus C, Laursen NS, Kwaks T, Zuijdgeest D, Khayat R, Ekiert DC, Lee JH, Metlagel Z, Bujny MV, Jongeneelen M, van der Vlugt R, Lamrani M, Korse HJ, Geelen E, Sahin Ö, Sieuwerts M, Brakenhoff JP, Vogels R, Li OT, Poon LL, Peiris M, Koudstaal W, Ward AB, Wilson IA, Goudsmit J, Friesen RH. Highly conserved protective epitopes on influenza B viruses. Science. 2012 Sep 14;337(6100):1343-8. Depetris RS, Julien JP, Khayat R, Lee JH, Pejchal R, Katpally U, Cocco N, Kachare M, Massi E, David KB, Cupo A, Marozsan AJ, Olson WC, Ward AB, Wilson IA, Sanders RW, Moore JP. Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers. J Biol Chem. 2012 Jul 13;287(29):24239-54. McLellan JS, Pancera M, Carrico C, Gorman J, Julien J-P, Khayat R, et al., Wilson IA, Kwang P. Structure of Variable Regions 1 and 2 of HIV-1 gp120 in Complex with Broadly Neutralizing Antibody PG9. Nature 2011 Nov. 23;480(7377):336-43. Pejchal R*, Doore KJ*, Walker LM*, Khayat R*, Huang PS*, Wang SK, et al., Wilson IA. A potent and Broad Neutralizing Antibody Recognizes and penetrates the HIV Glycan Shield. Science 2011 Nov. 25:334(6059):1097-103. * Contributing first author. Khayat R, Johnson JE. Pass the Jelly Rolls. Structure 2011 Jul 13; 19(7):904-6. Khayat R*, Brunn N, Speir JA, Hardham JM, Ankenbauer RG, Schneeman A, Johnson JE. The 2.3-angstrom structure of porcine circovirus 2. J. Virology. 2011 Aug;85(15):7856-62. *Corresponding author. Wang K, Fu CY, Khayat R, Doerschuk PC, Johnson JE. In Vivo Virus Structures: Simultaneous classification, resolution enhancement, and noise reduction in whole-cell electron tomography. J. Struct. Biol. 2011 Jun;174(3):425-33. Huang RK, Khayat R, Lee KK, Gertsman I, Duda RL, Hendrix RW, and Johnson JE. The Prohead-I structure of Bacteriophage HK97: Implications for Scaffold-mediated Control of Particle Assembly and Maturation. J. Mol. Biol. 2011 May 6; 408(3):541-54 Khayat R, Johnson JE. Evolution of Viral Capsid Structures – the Three Domains of Life. Structural Virology. Eds. Mavis Agbandje-McKenna and Robert McKenna. Royal Society of Chemistry 2011, 165-181. Fu C, Wang K, Gan L, Lanman J, Khayat R, Young MJ, Jensen GJ, Doerschuk PC, and Johnson JE. In vivo assembly of an archaeal virus studied with whole cell electron cryotomography. Structure 2010; 10(12);1579-1586. Matsui T, Lander G, Khayat R, Johnson JE. Subunits fold at position-dependent rates during maturation of a eukaryotic RNA virus. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):15111-5. Khayat R, Fu C, Ortmann AC, Young MJ, Johnson JE. The architecture and chemical stability of the archaeal Sulfolobus turreted icosahedral virus. J. Virology 2010; Sep; 84(18); 9575-83.