个人简介

Postdoc, Albert Einstein College of Medicine; Ph.D., New York University Postdoctoral studies, Albert Einstein College of Medicine - 1999 (Laser Spectroscopy of Proteins) Ph.D., New York University - 1993 (Chemistry, Physical) M.S., New York University - 1986 (Chemistry) M.S., University of Delaware - 1979 (Art Conservation) A.B., Wellesley College - 1976 (Art History)

研究领域

Molecular Biophysics and Biochemistry

Laura Juszczak's area of expertise is biophysical chemistry; her tools are spectroscopic, primarily UV resonance Raman. This technique is used to selectively probe aromatic residues in proteins, primarily tryptophan but also tyrosine. Such studies reveal details about protein conformation in both the normal and diseased state. This information allows us to understand the molecular level detail of the disease process, and helps researchers to design effective drugs.

近期论文

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A. Grigoryan, S. Eisenberg and L. J. Juszczak "Fluorescent 5-hydroxytryptophan derivative is a potent environmental probe: bioorthogonal labeling and solvatochromism." Biochemistry, MS in preparation (Books and Publications: Peer Reviewed Article) 2015 S. Eisenberg and L. J. Juszczak "Reduced Aromaticity: Correlation with Low Quantum Yield and Short Lifetime extended to Trp-Glu and Trp-Lys Dipeptides." J Comp Chem, MS in preparation (Books and Publications: Peer Reviewed Article) 2015 Eisenberg, S. and L.J. Juszczak. "The Broken Ring: Reduced Aromaticity in Lys-Trp Cations and High pH Tautomer Correlates with Lower Quantum Yield and Shorter Lifetimes." Submitted to Journal of Physical Chemistry B. (Books and Publications: Forthcoming Publications) 2014 Eisenberg, Azaria Solomon and Laura J. Juszczak. "Relating Trp-Glu Dipeptide Fluorescence to Molecular Conformation: The Role of the Discrete chi 1 and chi 2 Angles." Journal of Computational Chemistry. Article first published online, April 8 | DOI: 10.1002/jcc.23288. (Books and Publications: Peer Reviewed Article) 2013 Eisenberg, A.S. and Laura Juszczak. "Correlation of TrpGly and GlyTrp Rotamer Structure with W7 and W10 UV Resonance Raman Modes and Fluorescence Emission Shifts" Journal of Amino Acids. DOI: 10.1155/2012/735076. (Books and Publications: Forthcoming Publications) 2012 Meng, Xianwei, Trisheena Harricharran and Laura Juszczak. "A Spectroscopic Survey of Substituted Indoles Reveals Consequences of a Stabilized 1Lb Transition." Photochemistry and Photobiology. DOI 10.1111/j1751-1097. (Books and Publications: Forthcoming Publications) 2012 Juszczak, L.J. and R.Z.B. Desamero. "Extension of the Tryptophan Dihedral Angle - W3 Band Frequency Relationship to a Full Rotation: Correlations and Caveats." Biochemistry 48: 2777-87. (Books and Publications: Peer Reviewed Article) 2009 Maliga, Z., J. Xing, H. Cheung, L.J. Juszczak, J.M. Friedman and S.S. Rosenfeld. "A Pathway of Structural Changes Produced by Monastrol Binding to Eg5." Journal of Biological Chemistry 281: 7977-82. (Books and Publications: Peer Reviewed Article) 2006 Samuni, U., C.J. Roche, D. Dantsker, L.J. Juszczak and J. M. Friedman. "Modulation of Reactivity and Conformation within the T-quaternary State of Human Hemoglobin: The Combined Use of Mutagenesis and Sol-Gel Encapsulation." Biochemistry 45: 2820-35. (Books and Publications: Peer Reviewed Article) 2006 Juszczak, L., U. Samuni and J. M. Friedman. "The Conformational and Functional Significance of the α140 Side Chain in HbA: A UV and Visible Resonance Raman Study of the Three α140 Mutants." Journal of Raman Spectroscopy 36: 350-58. (Books and Publications: Peer Reviewed Article) 2005 Kavanaugh, J.S., L.J. Juszczak, P.H. Rogers, A. Arnone, Hilda L. Hui, Anita Wierzba, Alice DeYoung, Laura D. Kwiatkowski, Robert W. Noble, Eric S. Peterson and Joel M. Friedman. "Intersubunit Interactions Associated with Tyr42 alpha Stabilize the Quaternary-T Tetramer but Are Not Major Quaternary Constraints in Deoxyhemoglobin." Biochemistry 44: 3806-20. (Books and Publications: Peer Reviewed Article) 2005 "Comparative Vibrational Spectroscopy of Intracellular Tau and Extracellular Collagen I Reveals Parallels of Gelation and Fibrillar Structure." Journal of Biological Chemistry 279: 7395-404 and 18098. (Books and Publications: Peer Reviewed Article) 2004