Sun, Jiazhi - University of South Florida

个人简介

MS, West Virginia University, 1994 MBBS, Beijing Medical University, 1986

近期论文

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Kazi A, Sun J, Doi K, Sung SS, Takahashi Y, Yin H, Rodriguez JM, Becerril J, Berndt N, Hamilton AD, Wang HG, Sebti SM. The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner. The Journal of biological chemistry. 286(11) : 9382-92, 2011. http://www.ncbi.nlm.nih.gov/pubmed/21148306 Wei J, Kitada S, Rega MF, Emdadi A, Yuan H, Cellitti J, Stebbins JL, Zhai D, Sun J, Yang L, Dahl R, Zhang Z, Wu B, Wang S, Reed TA, Wang HG, Lawrence N, Sebti S, Reed JC, Pellecchia M. Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins. Molecular cancer therapeutics. 8(4) : 904-13, 2009. http://www.ncbi.nlm.nih.gov/pubmed/19372563 Hu X, Sun J, Wang HG, Manetsch R. Bcl-XL-templated assembly of its own protein-protein interaction modulator from fragments decorated with thio acids and sulfonyl azides. Journal of the American Chemical Society. 130(42) : 13820-1, 2008. http://www.ncbi.nlm.nih.gov/pubmed/18811158 Sun J, Wang DA, Jain RK, Carie A, Paquette S, Ennis E, Blaskovich MA, Baldini L, Coppola D, Hamilton AD, Sebti SM. Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors. Oncogene. 24(29) : 4701-9, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15897913 Sun J, Blaskovich MA, Jove R, Livingston SK, Coppola D, Sebti SM. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene. 24(20) : 3236-45, 2005. http://www.ncbi.nlm.nih.gov/pubmed/15735720 Sun J, Blaskovich MA, Jain RK, Delarue F, Paris D, Brem S, Wotoczek-Obadia M, Lin Q, Coppola D, Choi K, Mullan M, Hamilton AD, Sebti SM. Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor. Cancer research. 64(10) : 3586-92, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15150116 Jiang K, Sun J, Cheng J, Djeu JY, Wei S, Sebti S. Akt mediates Ras downregulation of RhoB, a suppressor of transformation, invasion, and metastasis. Molecular and cellular biology. 24(12) : 5565-76, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15169915 Paris D, Townsend K, Quadros A, Humphrey J, Sun J, Brem S, Wotoczek-Obadia M, DelleDonne A, Patel N, Obregon DF, Crescentini R, Abdullah L, Coppola D, Rojiani AM, Crawford F, Sebti SM, Mullan M. Inhibition of angiogenesis by Abeta peptides. Angiogenesis. 7(1) : 75-85, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15302999 Dasgupta P, Sun J, Wang S, Fusaro G, Betts V, Padmanabhan J, Sebti SM, Chellappan SP. Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis. Molecular and cellular biology. 24(21) : 9527-41, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15485920 Sun J, Ohkanda J, Coppola D, Yin H, Kothare M, Busciglio B, Hamilton AD, Sebti SM. Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice. Cancer research. 63(24) : 8922-9, 2003. http://www.ncbi.nlm.nih.gov/pubmed/14695209