Harding, Wayne - The City University of New York, CUNY

个人简介

Ph.D., University of the West Indies BSc. University of the West Indies (Mona), Ph.D. University of the West Indies (Mona), Postdoc University of Iowa

研究领域

Organic Chemistry, Biochemistry, and Medicinal Chemistry

近期论文

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Aporphinoid Antagonists of 5-HT2A Receptors: Further Evaluation of Ring A Substituents and the Size of Ring C. S. Ponnala, N. Kapadia, H. A. Navarro, W. W. Harding. Chem Biol Drug Des. 2014, Apr 25. doi: 10.1111/cbdd.12345. Evaluation of structural effects on 5-HT(2A) receptor antagonism by aporphines: identification of a new aporphine with 5-HT(2A) antagonist activity. S. Ponnala, J. Gonzales, N. Kapadia, H. A. Navarro, W. W. Harding. Bioorg. Med. Chem. Lett. 2014, 24, 1664-7. Facile synthesis of 4,5,6a,7-tetrahydrodibenzo[de,g]chromene heterocycles and their transformation to phenanthrene alkaloids. N. Kapadia, W. W. Harding Tetrahedron 2013, 69, 8914-8920 A New Route to Azafluoranthene Natural Products via Direct Arylation. S. Ponnala, W. W. Harding European J Org Chem. 2013, 3013, 1107-1115 Leonurenones A-C: Labdane diterpenes from Leonotis leonurus F. He, C. Lindqvist, W. W. Harding Phytochemistry. 2012, 83, 168-72 New aporphinoid 5-HT2A and α1A antagonists via structural manipulations of nantenine S. Chaudhary, S. Ponnala, O. Legendre, J. A. Gonzales, H. A. Navarro, W. W. Harding Bioorg Med Chem. 2011, 19, 5861-8 Cytotoxicity of aporphines in human colon cancer cell lines HCT-116 and Caco-2: an SAR study S. Ponnala, S, Chaudhary, A. González-Sarrias, N. P. Seeram, W. W. Harding Bioorg Med Chem Lett. 2011, 21, 4462-4. Synthesis of C-Homoaporphines via Microwave-Assisted Direct Arylation S. Chaudhary, W. W. Harding Tetrahedron 2011, 67, 569-575. Nantenine as an acetylcholinesterase inhibitor: SAR, enzyme kinetics and molecular modeling investigations S. Pecic, M. A. McAnuff, W. W. Harding J Enzyme Inhib Med Chem. 2011, 26, 46-55. Affinity of aporphines for the human 5-HT2A receptor: insights from homology modeling and molecular docking studies S. Pecic, P. Makkar, S. Chaudhary, B. V. Reddy, H. A. Navarro, W. W. Harding Bioorg Med Chem. 2010, 18, 5562-75 Microwave-assisted direct biaryl coupling: first application to the synthesis of aporphines. S. Chaudhary, O. LeGendre, S. Pecic and W.W. Harding Tetrahedron Letters 2009, 50, 2437-2439. ( ±)-Nantenine analogs as antagonists at human 5-HT2A receptors: C1 and flexible congeners. S. Chaudhary, O. LeGendre, S. Pecic and W.W. Harding. Biorganic and Medicinal Chemistry Letters 2009, 19, 2530-2532 Synthetic studies of neoclerodane diterpenes from Salvia divinorum: selective modification of the furan ring. W.W. Harding, M. Schmidt, K. Tidgewell, P. Kannan, K. G. Holden, C. M. Dersch, R. B. Rothman, T. E. Prisinzano. Bioorganic and Medicinal Chemistry Letters 2006, 16, 3170-3174. Enantioselective synthesis of (2R,3R) and (2S,3S)-2-[(3-chloro-phenyl)-(2-methoxy-phenoxy)-methyl]-morpholine. W.W. Harding, M. Hodge, D. Parrish, J. R. Deschamps, W. Woolverton and T. E. Prisinzano Tetrahedron:Asymmetry 2005, 16, 2249-2256. Neoclerodane Diterpenes as a novel Scaffold for µ opioid receptor ligands. W.W. Harding, K. Tidgewell, N. Byrd, H. Cobb, C. M. Dersch, E. R. Butelman, R. B. Rothman and T. E. Prisinzano. J. Med. Chem. 2005. 48, 4765-4771. Salvinicins A and B, new neoclerodane diterpenes from Salvia divinorum. W.W. Harding, K. Tidgewell, M. Schmidt, K. Shah, D. Parrish, J. R. Deschamps, J. Snyder, C. Dersch, R. B. Rothman and T. E. Prisinzano. Organic Letters, 2005, 7, 3017-3020. Pharmacokinetics of the plant-derived hallucinogen salvinorin A in non-human primates. T.E. Prisinzano, E. R. Butelman, M. S.. Schmidt, W. W. Harding, K. Tidgewell, M. J. Kreek, D. J. Murry Synapse 2005, 58, 208-210. Determination of Salvinorin A in body fluids by high performance liquid-chromatography-atmospheric pressure chemical ionization. M. S. Schimdt, T. E. Prisinzano, K. Tidgewell, W. Harding, E. R. Butelman, M. J. Kreek and D. J. Murry. Journal of Chromatography B 2005, 818, 221-225. A facile method for the preparation of deuterium labeled salvinorin A: synthesis of [2,2,2-2H3]-salvinorin A. K. Tidgwell, W. W. Harding, M. Schmidt, K. G. Holden, D.J. Murry and T. E. Prisinzano. Bioorganic and Medicinal Chemistry Letters 2004, 5099-5102.