个人简介

Ph.D., University of Michigan Ph.D., University of Michigan - Ann Arbor - 1994 (Chemistry, General) B.S., Florida State University - 1990 (Chemistry)

研究领域

Inorganic Chemistry, Molecular Biophysics and Biochemistry

While DNA is the blueprint for the cell, it is the proteins that do the bulk of the work. About 30% of proteins require metal ions for proper function and their dysfunction leads to human disease. The Gibney Lab takes a constructive approach toward understanding metalloprotein structure-function relationships. Using inorganic chemistry and protein biophysics, his lab designs and synthesizes simplified metalloproteins (maquettes) to test the fundamental tenets of metalloprotein engineering. - See more at: http://www.gc.cuny.edu/Page-Elements/Academics-Research-Centers-Initiatives/Doctoral-Programs/Chemistry/Faculty-Bios/Brian-R-Gibney#sthash.jco1x60A.dpuf

近期论文

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Chan, K.L., I. Bakman, A.R. Marts, Y. Batir, T.L. Dowd, D.L. Tierney and B.R. Gibney. "Characterization of the Zn(II) Binding Properties of the Wilms' Tumor Suppressor Protein C-terminal Zinc Finger Peptide." Inorganic Chemistry 53: 6309-20. (Books and Publications: Peer Reviewed Article) 2014 "Heme." Encyclopedia of Biophysics. Ed. Gordon Roberts. Springer. (Books and Publications: Other Article) 2013 "Metallopeptides as Tools to Understand Metalloprotein Folding and Stability." Protein Folding and Metal Ions -- Mechanisms, Biology and Disease. Eds. C.M. Gomes and P. Wittung-Stafshede. New York: CRC Press. 227-45. (Books and Publications: Chapter) 2011 Deng, B., S. Parthasarathy, W. Wang, B.R. Gibney, K.P. Battaile, S. Lovell, D.R. Benson and H. Zhu. "Unique Heme Pocket in Human Ncb5or and Structural Basis for Intra-Domain Electron Transfer., Journal of Biological Chemistry 285: 30181-91. (Books and Publications: Peer Reviewed Article) 2010 Reedy, C.J., M.M. Elvekrog and B.R. Gibney. "Development and Analysis of a Heme Protein Structure-Electrochemical Function Database." Nucleic Acids Research 36: D307-13. (Books and Publications: Peer Reviewed Article) 2008 Westerlund, K., S.D. Moran, H.K. Privett, S. Hay, J. Jarvet, B.R. Gibney and C.T. Tommos. "Making a Single-Chain Four-Helix Bundle for Redox Chemistry Studies." Proteins: Engineering, Design and Selection 21: 645-52. (Books and Publications: Peer Reviewed Article) 2008 Reddi, A.R. and B.R. Gibney. "The Role of Protons in the Thermodynamic Contribution of a Zn(II)-Cys4 Site Toward Protein Stability." Biochemistry 46: 3745-58. (Books and Publications: Peer Reviewed Article) 2007 Reddi, A.R., C.J. Reedy, S. Mui and B.R. Gibney. "Thermodynamic Investigation into the Mechanisms of Proton-Coupled Electron Transfer in Heme Protein Maquettes." Biochemistry 46: 291-305. (Books and Publications: Peer Reviewed Article) 2007 Reddi, A.R., T. Guzman, R.M. Breece, D.L. Tierney and B.R. Gibney. "Deducing the Energetic Cost of Protein Folding in Zinc Finger Proteins Using Designed Metallopeptides." Journal of the American Chemical Society 129: 12815-27. (Books and Publications: Peer Reviewed Article) 2007 Thompson, A. M., A.R. Reddi, X. Shi, R.A. Goldbeck, P. Moenne-Loccoz, B.R. Gibney and T.R. Holman. "Characterization of the Role of Heme-Binding in the Yeast Protein Dap1p." Biochemistry 46: 12629-37. (Books and Publications: Peer Reviewed Article) 2007 Hong, J., O.A. Kharenko, A.K. Petros, B.R. Gibney and M.Y. Ogawa. "A Miniature Cu(I) Metalloprotein Displays Unusual Electron-transfer Reactivity: Collisional Electron-transfer in the Inverted Marcus Region." Angewandte Chemie International Edition 2006 45: 6137-40. (Books and Publications: Peer Reviewed Article) 2006 Petros, A.K., A.R. Reddi, M.L. Kennedy, A.G. Hyslop and B.R. Gibney. "Femtomolar Zn(II) Affinity in a Peptide Ligand Designed to Model Thiolate-Rich Metalloprotein Active Sites." Inorganic Chemistry 45: 9941-58. (Books and Publications: Peer Reviewed Article) 2006 Riley, E.A., A.K. Petros, K.A. Smith, B.R. Gibney and D.L. Tierney. "Frequency-Switching Inversion-Recovery: Application to Severely Hyperfine Shifted NMR in Aqueous Solution." Inorganic Chemistry 45: 10016-18. (Books and Publications: Peer Reviewed Article) 2006 Zhuang, J., A.R. Reddi, Z. Wang, B. Khodaverdian, E.L. Hegg and B.R. Gibney. "Evaluating the Roles of the Heme a Sidechains in Cytochrome c Oxidase Using Designed Heme Proteins." Biochemistry 45: 12530-38. (Books and Publications: Peer Reviewed Article) 2006 Zhuang, J., J.H. Amoroso, R. Kinloch, J.H. Dawson, M.J. Baldwin and B.R. Gibney. "Evaluation of Electron-Withdrawing Group Effects on Heme Binding in Designed Proteins: Implications for heme a in cytochrome c oxidase." Inoragnic Chemistry 45: 4685-94. (Books and Publications: Peer Reviewed Article) 2006