个人简介
Dr. Barry Ache obtained a B.S. in biology at Albright College and an M.S. in behavior at the University of Illinois Urbana-Champaign. He earned his Ph.D. in behavioral physiology at the University of California, Santa Barbara in the Department of Biological Sciences
研究领域
Chemical Senses: Olfaction
近期论文
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Ache BW, Hein AM, Bobkov YV, and Principe JC, (2016) Smelling Time: A Neural Basis for Olfactory Scene Analysis. Trends in Neurosciences; Oct;39(10):649-655. doi: 10.1016/j.tins.2016.08.002. Review. PMID:27594700
Ukhanov K, Corey E, Ache BW, (2016) Phosphoinositide-3-Kinase Is the Primary Mediator of Phosphoinositide-Dependent Inhibition in Mammalian Olfactory Receptor Neurons. Front Cell Neurosci; Apr 11;10:97. doi: 10.3389/fncel.2016.00097. PMID:27147969
Park IJ, Hein AM, Bobkov YV, Reidenbach MA, Ache BW, Principe JC. Neurally encoding time for olfactory navigation. PLoS Comput Biol. 2016 Jan 5;12(1):e1004682. doi: 10.1371/journal.pcbi.1004682. PMID: 26730727
Corey EA and BW Ache. 2015. Comparative olfactory transduction. In: Zufall F and S Munger, eds. Chemosensory Transduction: Detection of Odor, Taste, and Other Chemostimuli. Elsevier Academic Press, San Diego. In press.
Ukhanov K, Bobkov Y, Corey, EA, Ache BW. Ligand-selective activation of heterologously-expressed mammalian olfactory receptor. Cell Calcium. 2014 Oct:56(4):245-56. Doi:10.1016/j.cea.2014.07.012. Epub 2014 Aug 4. PMID: 25149566. PubMed in progress.
Bobkov Y, Corey EA, Ache BW. An inhibitor of NA(+)/Ca(2+) exchange blocks activation of insect olfactory receptors. Biochem. Biophys. Res. Commun. 2014. Jul 25:450(2):1104-09. Doi:10.1016/j.bbrc.2014.06.120. Epub 2014 Jul 1. PMID: 24996179. PubMed- in progress.
Park IM, Bobkov YV, Ache BW, Príncipe JC Intermittency coding in the primary olfactory system: a neural substrate for olfactory scene analysis. J Neurosci. 2014 Jan 15;34(3):941-52. doi: 10.1523/JNEUROSCI.2204-13.2014. PMID: 24431452. PubMed – in process.
Park IJ, Bobkov YV, Ache BW, Principe JC. Quantifying bursting neuron activity from calcium signals with blind deconvolution. J Neurosci Meth. 2013 May 24. doi:pii: S0165-0270(13)00190-8. 10.1016/j.jneumeth.2013.05.007. Epub 2013 May 24. PMID: 23711821. PubMed – in process.
Ukhanov K, Corey EA, Ache BW. Phosphoinositide 3-kinase dependent inhibition as a broad basis for opponent coding in Mammalian olfactory receptor neurons. PLoS One. 2013 Apr 9;8(4):e61553. doi: 10.1371/journal.pone.0061553. Print 2013. PMID: 23585911; PMCID: PMC3621990.
Pask GM, Bobkov YV, Corey EA, Ache BW, Zwiebel LJ. Blockade of insect odorant receptor currents by amiloride derivatives. Chem Senses. 2013 Mar;38(3):221-9.doi: 10.1093/chemse/bjs100. Epub 2013 Jan 4. PMID: 23292750; PMCID: PMC3569625.
Corey EA, Bobkov Y, Ukhanov K, Ache BW. Ionotropic crustacean olfactory receptors. PLoS One. 2013;8(4):e60551. doi: 10.1371/journal.pone.0060551. Epub 2013 Apr 3. PMID: 23573266; PMCID: PMC3615998.
Bobkov Y, Park I, Ukhanov K, Principe J, Ache B. Cellular basis for response diversity in the olfactory periphery. PLoS One. 2012;7(4):e34843. doi: 10.1371/journal.pone.0034843. Epub 2012 Apr 13. Erratum in: PLoS One. 2012;7(4): doi/10.1371/annotation/b7163295-4bf4-4ddc-8a17-044c6eb54a5d. Park, Ill [corrected to Park, Il]. PMID: 22514675; PMCID: PMC3325939.
Ukhanov K, Bobkov Y, Ache BW. Imaging ensemble activity in arthropod olfactory receptor neurons in situ. Cell Calcium. 2011 Feb;49(2):100-7. Epub 2011 Jan 12. PMID: 21232792; PMCID: PMC3050052.
Ukhanov K, Brunert D, Corey EA, Ache BW. Phosphoinositide 3-kinase-dependent antagonism in mammalian olfactory receptor neurons. J Neurosci. 2011 Jan 5;31(1):273-80.PMID: 21209212; PMCID: PMC3079265.
Bobkov YV, Corey EA, Ache BW. The pore properties of human nociceptor channel TRPA1 evaluated in single channel recordings. Biochim Biophys Acta. 2011 Apr;1808(4):1120-8. Epub 2010 Dec 29. PMID: 21195050; PMCID: PMC3062711.
Ache BW. Odorant-specific modes of signaling in mammalian olfaction. Chem Senses. 2010 Sep;35(7):533-9. Epub 2010 Jun 2. Review. PMID: 20519266; PMCID: PMC2924424.
Bobkov YV, Pezier A, Corey EA, Ache BW. Phosphatidylinositol 4,5-bisphosphate-dependent regulation of the output in lobster olfactory receptor neurons. J Exp Biol. 2010 May;213(Pt 9):1417-24. PMID: 20400625; PMCID: PMC2856499.
Brunert D, Klasen K, Corey EA, Ache BW. PI3Kgamma-dependent signaling in mouse olfactory receptor neurons. Chem Senses. 2010 May;35(4):301-8. Epub 2010 Feb 26. PMID: 20190008; PMCID: PMC2854420.
Corey EA, Bobkov Y, Pezier A, Ache BW. Phosphoinositide 3-kinase mediated signaling in lobster olfactory receptor neurons. J Neurochem. 2010 Apr;113(2):341-50. Epub 2010 Feb 2. PMID: 20132480; PMCID: PMC2941884.