研究领域
Biochemistry, Physical Chemistry, and Molecular Biophysics
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Alphonse S, Arnold JJ, Bhattacharya S, Wang H, Kloss B, Cameron CE and Ghose R 2014.Cystoviral Polymerase Complex Protein P7 Uses its Acidic C-terminal Tail to Regulate the RNA-directed RNA Polymerase P2. J. Mol. Biol. 426, 2580-2593.
PicTemel DB*, Dutta K*,** and Ghose R** 2014. Sequence-specific 1H, 13C and 15N assignments of the catalytic domain of the Escherichia coli tyrosine kinase, Wzc. Biomolec. NMR Assignments. 8, 37-41.
PicRen Z*, Franklin MC* and Ghose R 2013. Structure of the RNA-directed RNA polymerase from the cystovirus Φ12. Proteins: Struct. Func. Bioinform. 81, 1479-1484. PDB:4IEG; 4GZK
PicTemel DB*, Dutta K*,**, Alphonse S, Nourikyan J, Grangegasse C and Ghose R**. 2013. Regulatory interactions between a bacterial tyrosine kinase and its cognate phosphatase. J. Biol. Chem. 288, 15212-15228.
PicGhose R 2013. A measured approach: determining the PLCγ1 docking site on Itk using a biochemical ruler. J. Mol. Biol. 425, 679-682.
PicPiserchio A, Francis D, Koveal D, Dalby KN, Page R, Peti W** and Ghose R** 2012. Docking Interactions of Hematopoietic Tyrosine Phosphatase (HePTP) with the MAP Kinases ERK2 and p38α. Biochemistry, 51, 8047-8049.
PicPiserchio A, Cowburn D and Ghose R 2012. Expression and Purification of Src-family KInases for Solution NMR Studies. Meth. Mol. Biol. 831, 111-131.
PicPiserchio A, Dalby K and Ghose R 2012. Assignment of Backbone Resonances in a Eukaryotic Protein Kinase - ERK2 as an Illustrative Example. Meth. Mol. Biol. 831, 359-368.
PicNatarajan A*, Dutta K*, Temel DB, Nair PA, Shuman S and Ghose R 2012. Solution structure and DNA-binding properties of the phosphoesterase domain of DNA ligase D. Nucl. Acids Res. 40, 2076-2088. PDB:2LJ6
PicPiserchio A, Warthaka M, Devkota A, Kaoud TS, Lee S, Abramczyk O, Ren P, Dalby KN** and Ghose R** 2011. Solution NMR Insights into Docking Interactions Involving Inactive ERK2. Biochemistry 50, 3660-3772.
PicLee S, Warthaka M, Yan C, Kaoud TS, Piserchio A, Ghose R, Ren P and Dalby KN 2011. A Model of a MAPK-Substrate Complex in Active Conformation: A Computational and Experimental Approach. PLOS One 6, e15894.
PicDutta K*, Natarajan A*, Nair P, Shuman S and Ghose R 2011. Sequence-specific 1H, 13C and 15N assignments of the phosphoesterase (PE) domain of Pseudomonas aeruginosa DNA ligase D (LigD). Biomolec. NMR Asgn. 5, 151-155.
PicRen Z and Ghose R 2011. Slow Conformational Dynamics in the Cystoviral RNA-directed RNA Polymerase P2 – Influence of Substrate Nucleotides and Template RNA. Biochemistry 50, 1875-1884.
PicFerrage F, Riechel A, Bhattacharya S, Cowburn D and Ghose R 2010. On the measurement of 15N-{1H} nuclear Overhauser effects 2. Effects of the saturation scheme and water signal suppression. J. Magn. Reson. 207, 294-303.
PicRen Z, Wang H and Ghose R 2010. Dynamics on multiple timescales in the RNA-directed RNA polymerase from the cystovirus Φ6. Nucleic Acids Res. 38, 5105-5118.
PicNicholas MP, Eryilmaz E, Ferrage F, Cowburn D and Ghose R 2010. Nuclear Spin Relaxation in isotropic and anisotropic media. Prog. NMR Spectroscopy 57, 111-158.
Pic Greenbaum NL and Ghose R 2010. Nuclear magnetic resonance (NMR) spectroscopy:Structure determination of proteins and nucleic acids. In Encyclopedia of Life Sciences (ELS). John Wiley & Sons, Ltd.:Chichester.
PicPiserchio A, Nair P, Shuman S and Ghose R 2010. Solution NMR Studies of Chlorella Virus DNA Ligase-Adenylate. J. Mol. Biol. 395, 291-308.
PicPiserchio A, Ghose R** and Cowburn D** 2009. Optimized Bacterial Expression and Purification of the c-Src Catalytic Domain for Solution NMR Studies. J. Biomol. NMR 44, 87-93.
PicFerrage F, Cowburn D and Ghose R 2009. Accurate Sampling of High-Frequency Motions in Proteins by Steady-State 15N-{1H} Nuclear Overhauser Effect Measurements in the Presence of Cross-Correlated Relaxation. J. Am. Chem. Soc. 131, 6048-6049.