个人简介

Ph.D., University of Salford (United Kingdom) Ph.D., University of Salford (United Kingdom) - 1981 (Biochemistry) B.Sc. (honors), University of Salford (United Kingdom) - 1977 (Biochemistry)

研究领域

Molecular Biophysics and Biochemistry

Professor Davenport's research in the laboratory focuses on studies of molecular interactions and fast conformational dynamics of large biomolecules. The lab uses state-of-the-art fluorescence spectroscopic methods. Funded through the Brooklyn College NIH-Score grant, they are currently using sensitive fluorescence methodologies to investigate the folding and stability of quadruplexed DNA found at the telomeric ends of chromosomes as an approach to designing better potential chemotherapeutics. - See more at: http://www.gc.cuny.edu/Page-Elements/Academics-Research-Centers-Initiatives/Doctoral-Programs/Chemistry/Faculty-Bios/Lesley-Davenport#sthash.WzOI9UIQ.dpuf

近期论文

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Kopkalli, Y., M. Zamadar, D. Aebisher, A. Greer and L. Davenport. "Studies of Quadruplex Folding Using a New Fluorescent Porphyrin Derivative." Biophysical Journal 100.3, Supplement 1: 234a. (Books and Publications: Abstract) 2011 Liu, S.X., Y. Kopkalli, A.V. Smirnov, J.R. Knutson and L. Davenport. "Fluorescence Studies of Local Environmental Heterogeneity Around Guanine Residues of the Telomeric DNA Quadruplex Conformation." Biophysical Journal 100.3, Supplement 1: 234a. (Books and Publications: Abstract) 2011 Kopkalli, Y., M. Chery, B.W. Willliams and L. Davenport. "Benzo[b]Fluorenone as a Quadruplex Interactive Agent (Qia): Binding Studies and Quadruplex Formation With the Human Telomeric HT4 Sequence." Biophysical Journal Supplement 98.3: 265a. (Books and Publications: Abstract) 2010 Liu, X., Y. Kopkalli, A.V. Smirnov, T. Rosales, M.E. Hawkins, J.R. Knutson and L. Davenport. "Local Dynamic Studies of Guanine Residues Within the Human Telomeric DNA G-Quadruplexed Conformation." Biophysical Journal Supplement 98.3: 265a. (Books and Publications: Abstract) 2010 Rosales, T., X. Liu, Y. Kopkalli, L. Davenport, M. Hawkins and J.R. Knutson. "G-Quadruplex Folding Observed by Two Photon Fluorescence Correlation Spectroscopy and Dual Time Scale." Biophysical Journal Supplement 98.3: 414a. (Books and Publications: Abstract) 2010 Liu, X., Y. Kopkalli and L. Davenport. "Conformational Stabilization of G-quadruplex DNA by Metalloporphyrins." Biophysical Society Meeting Abstracts, Biophysical Journal Supplement: 344a. (Books and Publications: Abstract) 2009 Liu, X.L., Y. Kopkalli, T. Vu, M.E. Hawkins and L. Davenport. "Conformational Stability of Fluorescently Labeled Human Telomeric G-Quadruplexed DNA Sequences." Biophysical Journal 94: 289a. (Books and Publications: Abstract) 2008 Martinez, A., Ch. S.K. Rajapakse, B. Naoulou, Y. Kopkalli, L. Davenport and R.A. Sanchez-Delgado. "The Mechanism of Antimalarial Action of the Ruthenium(II)-Chloroquine Complex [RuCl2(CQ)]2." Journal of Biological Inorganic Chemistry DOI 10.1007/s00775-008-0356-9. (Books and Publications: Peer Reviewed Article) 2008 Rosales, T., J. Xu, A.V. Smirnov, C. Combs, L. Davenport and J.R. Knutson. "Simultaneous Imaging of NAD+ and NADH Using CARS and 2-Photon Fluorescence Microscopy." Biophysical Journal 90S: 156a. (Books and Publications: Abstract) 2007 Davenport, L., A.V. Smirnov, C.A. Combs, K. Blinova, J.R. Knutson and R.S. Balaban. "Fluorescence Lifetime Imaging of NADH in Cells, in Solution and Encapsulated in Lipid Vesicles." Biophysical Journal 90S: 147a. (Books and Publications: Abstract) 2006 Jamison, J.L., L. Davenport and B. Williams. "Solvatochromic in the Aromatic Ketone Benzo(b)Fluorenone." Chemical Physics Letters 422: 30-35. (Books and Publications: Peer Reviewed Article) 2006 Kopkalli Y., M.J. Rosen and L. Davenport. "Interaction of N-Alkyl-2-Pyrrolidinone Surfactants with DMPC Lipid Bilayers." Biophysical Journal 90S: 505a. (Books and Publications: Abstract) 2006 Kopkalli, Y., M.J. Rosen and Lesley Davenport. "Interactions of N-alkyl-2-pyrrolidinone Surfactants with Dimyristoyilphosphatidylcholine Small Unilamellar Vesicles." Biophysical Journal 88, 70a, Abstract. (Books and Publications: Abstract) 2005 Kopkalli, Yasemin, Milton J. Rosen and Lesley Davenport. "Interactions of n-alkyl-2-pyrrolidinone Surfactants with Llipid Bilayers." Department of Chemistry, CUNY Graduate Center and Brooklyn College. Abstracts of Papers, 229th ACS National Meeting. San Diego, March 13-17, PHYS-489. Washington, D.C.: American Chemical Society. CODEN: 69GQMP Conference; meeting Abstract written in English. AN 2005:193605 CAPLUS (Copyright (c) 2006 ACS on SciFinder (R)). (Books and Publications: Abstract) 2005 Ramsook, C. and Lesley Davenport. "Effect of Guanidine Hydrochloride and Urea on the Conformation of BPAO." Bilophysical Journal 88, 38a, Abstract. (Books and Publications: Abstract) 2005 Voloshchuk, N., M.E. Hawkins and Lesley Davenport. "Mapping the DNA Binding Site of HIV-1 Integrase Using Fluorescent Oligonucleotides and Fluorescence Polarization." Biophysical Journal 88: 406a. (Books and Publications: Abstract) 2005