Zorio, Diego - Florida State University - Department of Biomedical Sciences

个人简介

Education Postdoctoral Research, University of Colorado Health Sciences Center UCHSC, Denver CO Ph.D., Indiana University, Bloomington, IN – MCDB program B.S., Federal University Rio de Janeiro, Brazil, UFRJ. Career Experience 2009-2015 Associate Scholar - Department of Chemistry & Biochemistry, Florida State University 2005-2009 Principal Investigator – Taxolog, Inc. Tallahassee, FL 2004-2005 Instructor – Department of Chemistry and Molecular Genetics, UCHSC, Denver CO

近期论文

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Bosco, D., Kenworthy, R., Zorio, D. A. R.* and Sang, Q-X. A. (2015) Human Mesenchymal Stem Cells are Resistant to Paclitaxel by Adopting a Non-Proliferative Fibroblastic State. PLoS One. 10(6):e012851. * Co-corresponding authors Rexford, A. M., Zorio, D. A. R. and Miller, B. G. (2015) Biochemical and biophysical Investigations do not support a direct interaction between human glucokinase and pro-apoptotic BAD. Submitted Martins, A. S., Parvatiyar, M. S., Feng, H-F., Bos, M. J., Martinez, D. G., Vukmirovic, M., Turna, R., Sanches-Gonzalez, M. A., Badger, C-D., Zorio, D. A., Singh, R. K.,Wang, Y., Jin, J-P., Ackerman, M. J., and Pinto, J. R. (2015) In vivo Analysis of Troponin C Knock-in (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility Gene. Circ Cardiovasc Genet. In Press. Khamis, I. Z., Zorio, D. A. R.*, Chung, L. W. K., and Sang, Q-X. A*. (2013). The Anti-inflammatory Role of Endometase/Matrilysin-2 in Human Prostate Cancer Cells. . J Cancer. 4, 296-303. *Co-corresponding authors Yang, W-Y., Roy, S., Phrathep, B., Rengert, Z., Kenworthy, R., Zorio, D. A. R. and Alabugin, Y.V. (2011) Engineering pH-Gated Transitions for Selective and Efficient Double Strand DNA Photocleavage in Hypoxic Tumors. J Med Chem. 54, 8501-16. Yang, W-Y., Marrone,S. A., Minors, N., Zorio, D. A. R. and Alabugin, Y. V. (2011) Fine-tuning alkyne cycloadditions: Insights into photochemistry responsible for the double-strand DNA cleavage via structural perturbations in diaryl alkyne conjugates.s. Beilstein J. Org. Chem. 7, 813–823. DeLigio, T. and Zorio, D. A. R. (2009). Early Growth Response 1 (EGR1): A gene with as many names as biological functions. Cancer Biol Ther. 8:20, 1885-1888. DeLigio, T., Velkova, A, Zorio, D. A. R. and Monteiro, A. (2009) Can BRCA1 predict response to taxane-based cancer therapy? Anticancer Agents Med. Chem. 9, 543-549. Hollins, C., Zorio, D. A. R., MacMorris, M. and Blumenthal, T. (2005). U2AF Binding selects for the high conservation of the C. elegans 3’splice site. RNA 11, 248-253. *Schroeder, S., *Zorio, D. A. R., Schwer, B., Shuman, S. and Bentley, D. (2004). Yeast mRNA cap methyltransferase Abd-1 functions as a transcription factor for RNA polymearse II. Mol Cell 13, 377-387. *Co-authors. Bird, G. A., Zorio, D. A. R. and Bentley, D. L. (2004). RNA polymerase II CTD phosphorylation is required for co-transcriptional pre-mRNA splicing and 3’ end formation. Mol. Cell. Biol. 24, 8963-8969. Zorio, D. A. R. and Bentley, D. L. (2004).The link between mRNA processing and transcription: communication works both ways. Exp. Cell Res 296, 91-97. Zorio, D. A. R. and Bentley, D. L. (2001). Transcription Elongation: The "Foggy" Is lifting...Curr. Biol 11, R144-146. Penalva, L. O. F. and Zorio, D. A. R. (2001). Processing the Genetic Information. Review article in Portuguese. Ciência Hoje 29 (171), 34-39. Zorio, D. A. R. and Blumenthal, T. (1999). Both subunits of U2AF recognize the 3’ splice site in C. elegans. Nature 402, 835-838. Zorio, D. A. R. and Blumenthal, T. (1999). U2AF35 is encoded by an essential gene clustered in an operon with RRM/cyclophilin in C. elegans. RNA 5, 487-494. MacMorris, M., Zorio, D. A. R. and Blumenthal T. (1999). An exon that prevents transport of a mature mRNA. Proc. Natl. Acad. Sci. USA. 96, 3813-3818. Zorio, D. A. R., Lea, K., and Blumenthal, T. (1997). Cloning of Caenorhabditis U2AF65: an alternatively spliced RNA containing a novel exon. Mol. Cell. Biol. 17, 946-953. Evans, D., Zorio, D. A. R., MacMorris, M., Winter, C. E., Lea, K. and Blumenthal, T. (1997). Operons and SL2 Trans-splicing exist in nematodes outside the genus Caenorhabditis. Proc. Natl. Acad. Sci. USA. 94, 9751-9756. Zorio, D. A. R. and Blumenthal, T. (1995) Coregulated gene clusters in animals Journal of NIH Research 7, 53-54. Zorio, D. A. R., Cheng, N., Blumenthal, T. and Spieth, J. (1994). Operons represents a common form of chromosomal organization in C. elegans. Nature 372, 270-272. Moura-Neto, R. S., Silva, R., Carvalho, E. F. and Zorio, D. A. R.(1993). Comparison of Rio de Janeiro DNA Typing data with the FBI Worldwide study. Journal of the Brazilian Association for the Advancement of Science. 45, 258-262.