Tomko Jr., Robert J - Florida State University - Department of Biomedical Sciences

个人简介

Postdoctoral Research, Yale University, Department of Molecular Biophysics and Biochemistry Ph.D., Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine B.S., Biochemistry and Molecular Biology, Lebanon Valley College

近期论文

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Tomko, Jr., R.J.,* Taylor, D.W., Chen, Z.A., Wang, H.W., Rappsilber, J., and Hochstrasser, M. A Single Alpha Helix Drives Largescale Remodeling of the Proteasome Lid and Completion of Regulatory Particle Assembly. Cell. 163: 432-444.*Corresponding Author Li, Y., Tomko, Jr., R.J., and Hochstrasser, M. Proteasomes: Isolation and activity assays. Curr. Protoc. Cell Biol. 67:3.43.1-3.43.20.1. Tomko, R. J. Jr., and Hochstrasser, M. The Intrinsically Disordered Sem1 Protein Functions as a Molecular Tether During Proteasome Lid Biogenesis. Molecular Cell. 53: 433–443, 2014. Sá-Moura, B., Funakoshi, M., Tomko, R. J. Jr., Dohmen, J., Wu, Z., Peng, J., and Hochstrasser, M. A Conserved Protein with AN1 Zinc-finger and Ubiquitin-like Domains Modulates Cdc48 (p97) Function in the Ubiquitin-Proteasome Pathway. Journal of Biological Chemistry. 288: 33682-96, 2013. Tomko, R. J. Jr., and Hochstrasser, M. Molecular Architecture and Assembly of the Eukaryotic Proteasome. Annual Review of Biochemistry. 82: 415-45, 2013. Tomko, R. J. Jr., and Hochstrasser, M. Incorporation of the Rpn12 Subunit Couples Completion of Proteasome Regulatory Particle Lid Assembly to Lid-Base Joining. Molecular Cell. 44: 907-917, 2011. Tomko, R. J. Jr., and Hochstrasser, M. Order of the proteasomal ATPases and eukaryotic proteasome assembly. Cell Biochemistry & Biophysics. 60: 13-20, 2011. Heinemann, I., Randau, L., Tomko, R. J. Jr., and S?ll, D. 3’-5’ tRNAHis guanylyltransferase in bacteria. FEBS Letters. 584: 3567-3572, 2010. Tomko, R. J. Jr., Funakoshi, M., Schneider, K., Wang, J., and Hochstrasser, M. Heterohexameric ring arrangement of the eukaryotic proteasomal ATPases: implications for proteasome structure and assembly. Molecular Cell. 38: 393-403, 2010. *Featured in: Mol. Cell. 2010; 38: 319-20.*Recommended by Faculty of 1000 Wang, P., Zou, F., Zhang, X., Tomko, R. J. Jr., Lazo, J. S., Wang, Z., Zhang, L., and Yu, J. MicroRNA-21 modulates G2/M checkpoint and cell cycle progression through Cdc25A. Cancer Research. 69: 8157-65, 2009. Funakoshi, M., Tomko, R. J. Jr., Kobyashi, H., and Hochstrasser, M. Multiple assembly chaperones govern biogenesis of the proteasome regulatory particle base. Cell. 137: 887-899, 2009. *Featured in: Cell. 2009; 138:25-8.*Featured in: Nature Reviews Molecular Cell Biology. 2009; 10:442-3.*Featured in: Biopolymers. 9: iii, 2009.*Recommended by Faculty of 1000 Tomko, R. J. Jr., Azang-Njaah, N. N., and Lazo, J. S. Nitrosative stress suppresses checkpoint activation after DNA synthesis inhibition. Cell Cycle. 8: 299-305, 2009. Tomko, R. J. Jr., and Lazo, J. S. Multimodal control of Cdc25A by nitrosative stress. Cancer Research. 68: 7457-7465, 2008. Queiroz de Oliveira, P. E., Tomko, R. J. Jr., and Lazo, J. S. Is a step backwards in S-phase-targeted chemotherapy a step forward? Molecular Interventions. 8: 137-40, 2008.*Cover article Brisson, M., Foster, C., Wipf, P., Joo, B., Tomko, R. J. Jr., Nguyen, T., and Lazo, J. S. Independent mechanistic inhibition of Cdc25 phosphatases by a natural product caulibugulone. Molecular Pharmacology. 71: 184-92, 2007. Tomko, R. J. Jr., Bansal, P., and Lazo, J. S. Airing out an antioxidant role for the tumor suppressor p53. Molecular Interventions. 6: 23-25, 2006. Aponick, A., Buzdygon, R. S., Tomko, R. J. Jr., Fazal, A. N., Shughart, E. L., McMaster, D. M., Meyers, M. C., Pitcock, W. H. Jr., and Wigal, C. T. Regioselective organocadmium alkylations of substituted quinones. Journal of Organic Chemistry. 67: 242-244, 2002.