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Baxley, T., Johnson, D., Pinto, J.R., Chalovich, J.M. Troponin C mutations partially stabilize the active state of regulated actin and fully stabilize the active state when paired with D14 TnT. Biochemistry. May 22 (in press), 2017. doi: 10.1021/acs.biochem.6b01092.
Bollen, I.A.E., Schuldt, M., Harakalova, M., Vink, A., Asselbergs, F.W., Pinto, J.R., Krüger, M., Kuster, D.W.D., Van der Velden, J. Genotype-specific pathogenic effects in human dilated cardiomyopathy. J. Physiol. Apr 24 (in press), 2017. doi: 10.1113/JP274145.
Dossat, A.M., Sanchez-Gonzalez, M.A., Koutnik, A.P., Leitner, S., Ruiz, E.L., Griffin, B., Rosenberg, J.T., Grant, S.C., Fincham, F.D., Pinto, J.R., Kabbaj, M. Pathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy. FASEB J. Feb 24. (in press), 2017. doi: 10.1096/fj.201600955RR.
Kawai, M., Johnston, J.R., Karam, T., Wang, L., Singh, R.K., Pinto, J.R. Myosin Rod Hypophosphorylation and CB Kinetics in Papillary Muscles from a TnC-A8V KI Mouse Model. Biophys. J. (London) 112(8): 1726-1736, 2017. doi: http://dx.doi.org/10.1016/j.bpj.2017.02.045
Veltri, T., Landim-Vieira, M., Parvatiyar, M.S., Gonzalez-Martinez, D., Dieseldorff Jones, K.M., Michell, C.A., Dweck, D., Landstrom, A.P., Chase, P.B., Pinto, J.R. Hypertrophic cardiomyopathy cardiac Troponin C mutations defferentially affect slow skeletal and cardiac muscle regulation. Front. Physiol. April(8): 221, 2017. doi: 10.3389/fphys.2017.00221.
Veltri, T., de Oliveira, G.A., Bienkiewicz, E.A., Palhano, F.L., Marques, M.A., Moraes, A.H., Silva, J.L., Sorenson, M.M., Pinto, J.R. Amide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca2+-binding affinity in a C-domain mutant of cardiac troponin C. Sci Rep. Apr 6;7(1):691, 2017. doi: 10.1038/s41598-017-00777-6.
Pinto, J.R., Muller-Delp, J., Chase, P.B. Will you still need me (Ca2+ , TnT, and DHPR), will you still cleave me (calpain), when I'm 64? Aging Cell. Apr;16(2):202-204, 2017. doi: 10.1111/acel.12560
Marques, M.A., Pinto, J.R., Moraes, A.H., Iqbal, A., de Magalh?es, M.T., Monteiro, J., Pedrote, M.M., Sorenson, M.M., Silva, J.L., de Oliveira, G.A. Allosteric transmission along a loosely structured backbone allows a cardiac Troponin C mutant to function with only one Ca2+ ion. J Biol Chem. Feb 10;292(6):2379-2394, 2017. doi: 10.1074/jbc.M116.765362.
Badr, M.A., Pinto, J.R., Davidson, M.W., Chase, P.B. Fluorescent Protein-Based Ca2+ Sensor Reveals Global, Divalent Cation-Dependent Conformational Changes in Cardiac Troponin C. PLoS One. Oct 13;11(10):e0164222, 2016. doi: 10.1371/journal.pone.0164222
Sheng, J.J., Feng, HZ., Pinto, J.R., Wei, H., Jin, J.P. Increases of desmin and a-actinin in mouse cardiac myofibrils as a response to diastolic dysfunction. J Mol Cell Cardiol. Oct;99:218-229, 2016. doi: 10.1016/j.yjmcc.2015.10.035
Na, I., Kong, M.J., Straight, S., Pinto, J.R., Uversky, V.N. Troponins, intrinsic disorder, and cardiomyopathy. Biol Chem. Aug 1;397(8):731-51, 2016. doi: 10.1515/hsz-2015-0303
Zot, H.G., Hasbun, J.E., Michell, C.A., Landim-Vieira, M., Pinto, J.R. Enhanced troponin I binding explains the functional changes produced by the hypertrophic cardiomyopathy mutation A8V of cardiac troponin C. Arch Biochem Biophys. Jul 1;601:97-104, 2016. doi: 10.1016/j.abb.2016.03.011
Figueiredo-Freitas, C., Dulce, R., Foster, M.W., Liang, J., Yamashita, A.M., Lima-Rosa, F.L., Thompson, W.J., Moseley, A.M., Hare, J.M., Nogueira, L., Sorenson, M.M., Pinto, J.R. S-nitrosylation of sarcomeric proteins depresses myofilament Ca2+ sensitivity in intact cardiomyocytes. Antioxid Redox Signal. Nov 1;23(13):1017-34, 2015. doi: 10.1089/ars.2015.6275
Martins, A.S., Parvatiyar, M.S., Feng, HZ., Bos, J.M., Gonzalez-Martinez, D., Vukmirovic, M., Turna, R.S., Sanchez-Gonzalez, M.A., Badger, C.D., Zorio, D.A., Singh, R.K., Wang, Y., Jin, J.P., Ackerman, M.J., Pinto, J.R. In vivo Analysis of Troponin C Knock-in (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility Gene. Circ Cardiovasc Genet. Oct;8(5):653-64, 2015
Chang, A.N., Battiprolu, P.K., Cowley, P.M., Chen, G., Gerard, R.D., Pinto, J.R., Hill, J.A., Baker, A.J., Kamm, K.E., Stull, J.T. Constitutive Phosphorylation of Cardiac Myosin Regulatory Light Chain in vivo. J. Biol. Chem. 290(17):10703-16, 2015
Parvatiyar, M.S. and Pinto, J.R. Pathogenesis Associated with a Restrictive Cardiomyopathy Mutant in Cardiac Troponin T is Due to Reduced Protein Stability and Greatly Increased Myofilament Ca2+ Sensitivity. Biochim. Biophys. Acta. Feb;1850(2):365-72, 2015
Chang, A.N., Greenfield, N.J., Singh, A., Potter, J.D., Pinto, J.R. Structural and protein interaction effects of hypertrophic and dilated cardiomyopathic mutations in alpha-tropomyosin. Front. Physiol. Dec 2;5:460, 2014
Dweck, D., Sanchez-Gonzalez, M.A., Chang, A., Dulce, R., Badger, CD., Koutnik, A.P., Ruiz, E.L., Griffin, B., Liang, J., Kabbaj, M., Fincham, F., Hare, J., Overton, M.J., Pinto, J.R. Long term ablation of PKA-mediated cardiac troponin I phosphorylation leads to excitation-contraction uncoupling and diastolic dysfunction in a Knock-in mouse model of Hypertrophic Cardiomyopathy. J. Biol. Chem. 289:23097-23111, 2014
Bai, F., Caster, H.M., Pinto, J.R., and Kawai, M. Functional properties of cardiomyopathy causing cTnT mutants I79N, DE96 and DK210: molecular pathogenesis study. Biophys. J. (London) 104(9): 1979-1988, 2013
Venkataraman, R., Baldo, M.P., Hwang, H., Veltri, T., Pinto, J.R., Baudenbacher, F.J., Knollmann, B.C. Myofilament calcium de-sensitization and contractile uncoupling with blebbistatin prevents ventricular tachycardia in mouse hearts with chronic myocardial infarction. J. Mol. Cell. Cardiol. 60C: 8-15, 2013
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