Kaplan, Daniel L - Florida State University - Department of Biomedical Sciences

个人简介

Ph.D. Yale University, New Haven, Connecticut September 1994 to August 2000 Degree Date: December 15, 2000 Molecular Biophysics and Biochemistry Dissertation Title: Mechanistic Studies of DnaB Helicase Mentor’s Name: Thomas A. Steitz Yale University School of Medicine, New Haven, Connecticut September 1988 to January 1992 Passed Part I of National Medical Board Examination in 1990. Completed 2 ? years of medical school training and a one-year research NIH Cancer Research Fellowship. Bachelor of Arts, University of Virginia, Charlottesville, Virginia September 1984 to May 1988 Degree Date: May 1988 Interdisciplinary

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C Eielson, D Kaplan, MA Mitnick, I Paliwal, K Insogna. “Estrogen modulates parathyroid hormone-induced fibronectin production in human and rat osteoblast-like cells.” Endocrinology 135: 1639-1644 (1994). PMID: 8647916. DL Kaplan, WF Boron. “Long-term expression of c-H-ras stimulates Na-H and Na+-dependent Cl-HCO3 exchange in NIH 3T3 fibroblasts.” J. Biol. Chem. 269: 4116-4124 (1994). PMID: 8307971. DL Kaplan, CM Eielson, MC Horowitz, KL Insogna, EC Weir. “Tumor necrosis factor-alpha induces transcription of the colony-stimulating factor 1 gene in murine osteoblasts.” J. Cell Physiol. 168: 199-208 (1996). PMID: 8647916. DL Kaplan, TA Steitz. “DnaB from Thermus aquaticus Unwinds Forked Duplex DNA with an Asymmetric Tail Length Dependence.” J. Biol. Chem. 274: 6889-6897 (1999). PMID: 10066742 DL Kaplan. “The 3’-tail of a Forked-Duplex Sterically Determines Whether One or Two DNA Strands Pass Through the Central Channel of a Replication Fork Helicase.” J. Mol. Biol. 301: 285-299 (2000). PMID: 10926510. DL Kaplan, M O'Donnell. “DnaB Drives DNA Branch Migration and Dislodges Proteins While Encircling Two DNA Strands.” Mol. Cell 10: 647-657 (2002). PMID: 12408831. DL Kaplan and M O’Donnell. “Rho Factor: Transcription Termination in Four Steps.” Curr. Biol. 13: R714-R716 (2003). PMID: 13678611. DL Kaplan, MJ Davey, M O'Donnell. “Mcm4,6,7 Uses ‘Pump in Ring’ Mechanism to Unwind DNA by Steric Exclusion and Actively Translocate Along a Duplex.” J. Biol. Chem. 278: 49171-49182 (2003). PMID: 13679365. DL Kaplan and M O'Donnell. “Twin DNA Pumps of a Hexameric Helicase Provide Power to Simultaneously Melt Two Duplexes.” Mol. Cell 15: 453-465 (2004). PMID: 15304224. DL Kaplan and M O'Donnell. “RuvA Is a Sliding Collar that Protects Holliday Junctions from Unwinding while Promoting Branch Migration.” J. Mol. Biol. 355: 473-490 (2006). PMID: 16324713. DL Kaplan. “Replication Termination: Mechanism of Polar Arrest Revealed.” Curr. Biol. 16: R684-686 (2006). PMID: 16950091. DM Kanter, I Bruck, and DL Kaplan. “Mcm subunits can assemble into two different active unwinding complexes.” J. Biol. Chem. 283:31172-1182 (2008). PMID: 18801730. DL Kaplan and D Bastia. “Mechanisms of polar arrest of a replication fork.” Mol. Microbiol. 72:27-285 (2009). PMID: 19298368. I Bruck and D Kaplan. “Dbf4-Cdc7 phosphorylation of Mcm2 is required for cell growth.” J. Biol. Chem. 284:28823-31 (2009). PMID: 19692334. DL Kaplan and I Bruck. “Methods to study kinase regulation of the replication fork helicase.” Methods. 51:358-62 (2010). PMID: 20170732. CE Wickersham, KJ Cash, SH Pfeil, I Bruck, DL Kaplan, KW Plaxco, and EA Lipman. “Tracking a molecular motor with a nanoscale optical encoder.” Nano Lett. 10:1022-1027 (2010). PMID: 20121107. DL Kaplan and I Bruck. “Methods to study how replication fork helicases unwind DNA.” Methods Mol Biol. 587:127-35 (2010). PMID: 20225146 N Ribeck, DL Kaplan, I Bruck, OA Saleh, “DnaB helicase activity is modulated by DNA geometry and force.” Biophys J. 99:2170-9 (2010). PMID: 20923651 DM Kanter and DL Kaplan, "Sld2 binds to origin ssDNA and stimulates DNA annealing." Nucleic Acids Res. 39: 2580-2592 (2011) PMID: 21109535. I. Bruck and DL Kaplan, "GINS and Sld3 compete with one another for Mcm2-7 and Cdc45 binding." J. Biol. Chem. 286:14157-67 (2011) PMID: 21362622. I. Bruck and DL Kaplan, "Origin Single-stranded DNA Releases Sld3 Protein from the Mcm2-7 Complex, Allowing the GINS Tetramer to Bind the Mcm2-7 Complex." J. Biol. Chem. 286:18602-13 (2011) PMID: 21460226. I. Bruck, DM Kanter, and DL Kaplan "Enabling Association of the GINS Protein Tetramer with the Mini Chromosome Maintenance (Mcm)2-7 Protein Complex by Phosphorylated Sld2 Protein and Single-stranded Origin DNA." J. Biol. Chem. 286:36414-26 (2011) PMID: 21868389. AN Suhasini, JA Sommers, S Yu, Y Wu, T Xu, Z Kelman, DL Kaplan, and RM Brosh, Jr. “DNA Repair and Replication Fork Helicases are Differentially Affected by an Alkyl Phosphotriester Lesion.” J. Biol. Chem. 287:19188-98 (2012) PMID: 22465574. DL Kaplan, OA Saleh, and N Ribeck “Single-molecule and bulk approaches to the DnaB replication fork helicase.” Front. Biosci. 18: 224-40 (2013) PMID: 23276919. I Bruck and DL Kaplan, “Cdc45-ssDNA interaction is important for stalling the helicase during replication stress.” J Biol Chem. 288: 7550-63 (2013) PMID: 23382391.