Hurt, Myra M - Florida State University - Department of Biomedical Sciences

个人简介

Dr. Hurt has been involved in medical education for more than 25 years, first at the University of Tennessee and later at the Baylor College of Medicine. She came to FSU in 1987 and joined the team of professors teaching biochemistry to medical students in the Program in Medical Sciences (PIMS). In 1992, Dr. Hurt became the Director of PIMS, working closely with the University of Florida College of Medicine to assure the quality of the first-year medical education program at FSU. In 1992, Dr. Hurt joined the faculty of the department of biological science, where she earned tenure. She taught microbiology to undergraduates, advanced molecular biology to graduate students, and taught an Honors Seminar in the FSU Honors Program. She served as acting dean of the new College of Medicine from 2000 to 2001. She was associate dean for student affairs, admissions and outreach from 2001-2004 and assumed the role of associate dean for research and graduate programs in 2004. She was named senior associate dean for research and graduate programs in 2009. She is the founding faculty member of the College of Medicine, and leads a molecular biology research group engaged in dissecting the regulation of cellular division at the molecular level through the phosphorylation of YY1. She enjoys working with students in the laboratory and has directed the research of nine students who earned their Ph.D. degree, two who earned an M.S., 2 more students currently working toward their degrees and over 30 undergraduate researchers at FSU since 1992.

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Rizkallah R, Batsomboon P, Dudley GB, Hurt MM.Identification of the oncogenic kinase TOPK/PBK as a master mitotic regulator of C2H2 zinc finger proteins. Oncotarget. 2015 Jan 30;6(3):1446-61. Xu Z, Graham K, Foote M, Liang F, Rizkallah R, Hurt M, Wang Y, Wu Y, Zhou Y.14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes .J Cell Sci. 2013 Sep 15;126(Pt 18):4173-86. doi: 10.1242/jcs.126102. Richmond D, Rizkallah R, Liang F, Hurt MM, Wang Y. Slk19 clusters kinetochores and facilitates chromosome bipolar attachment. Mol Biol Cell. 2013 Mar;24(5):566-77. doi: 10.1091/mbc.E12-07-0552. Kassardjian A, Rizkallah R, Riman S, Renfro SH, Alexander KE, Hurt MM. The transcription factor YY1 is a novel substrate for Aurora B kinase at G2/M transition of the cell cycle. PLoS One. 2012;7(11):e50645. doi: 10.1371/journal.pone.0050645. Riman S., Rizkallah, R., Kassardjian, A., Alexander K.E., Lüscher, B., and Hurt, M.M. Phosphorylation of the Transcription Factor YY1 by CK2a Prevents Cleavage by Caspase 7 during Apoptosis. Mol. Cell. Biol. 2012; 32(4): 797-807. Moseley S.C., Rizkallah R., Tremblay D.C., Anderson B.R., Hurt M.M., Chadwick B.P. YY1 associates with the macrosatellite DXZ4 on the inactive X chromosome and binds with CTCF to a hypomethylated form in some male carcinomas. Nucleic Acids Res. 2012 Feb 1;40(4):1596-608. Rizkallah R, Alexander KE, Hurt MM. Global mitotic phosphorylation of C2H2 zinc finger protein linker peptides. Cell Cycle. 2011 Oct 1;10(19):3327-36. Rizkallah R, Alexander K.E., Kassardjian A, Lüscher B, Hurt M.M. (2011) The Transcription Factor YY1 Is a Substrate for Polo-Like Kinase 1 at the G2/M Transition of the Cell Cycle. PLoS ONE 6(1): e15928. doi:10.1371/journal.pone.0015928 Rizkallah, R. and Hurt, M.M. Regulation of the Transcription Factor YY1 in Mitosis through Phosphorylation of Its DNA-binding Domain. Mol. Biol. Cell 2009; 20(22):4766-4776. Hurt M.M., Littles A.B. The price of changing the status quo. Acad Med. 2009 Feb;84(2):151. Beyrouthy M.J., Alexander K.E., Baldwin A., Whitfield M.L., Bass H.W., McGee D., and Hurt M.M. (2008) Identification of G1-Regulated Genes in Normally Cycling Human Cells. PLoS ONE 3(12): e3943. doi:10.1371/journal.pone.0003943 Hurt M.M., Harris J.O. Founding a new College of Medicine at Florida State University. Acad Med. 2005 Nov;80(11):973-9. Krippner-Heidenreich, A., Walsemann, G., Beyrouthy, M., Speckgens, S., Kraft, R., Thole, H., Talanian, R., Hurt, M.M., and Lüscher, B. (2005) Caspase-dependent regulation and subcellular redistribution of the transcription modulator YY1 during apoptosis. Molecular and Cellular Biology 25 (9): 3704-3714. Palko L., Bass H.W., Beyrouthy M.J., and Hurt M.M. The Yin Yang-1 (YY1) protein undergoes a DNA replication-associated switch in localization from the cytoplasm to the nucleus at the onset of S phase. Journal of Cell Sci. 2004; 117(3):465-476. Whitfield, M.L., Sherlock, G., Saldanha, A., Murray, J., Ball, C., Alexander, K., Matese, J., Perou, C., Hurt, M.M., Brown, P., and Botstein, D. 2002. Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Molecular Biology of the Cell. 13: 1977-2000. Eliassen, K., Baldwin, A., Sikorski, E., and Hurt, M.M. 1998. Role for a YY1 binding element in replication-dependent mouse histone gene expression. Mol. Cell. Biol. 18:7106-7118.