Horabin, Jamila I - Florida State University - Department of Biomedical Sciences

个人简介

B.A., Duke University. Major: Chemistry. Summa Cum Laude. (1981) Ph.D, Duke University. Major: Biochemistry, Genetics. Supervisor: Robert Webster, Ph.D.(1987) Postdoctoral training, Department of Molecular Biology, Princeton University, Princeton, N.J. Mentor: Paul Schedl, Ph.D. (1988–1993)

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Cabrera, J. R., Olcese, U. and Horabin, J. I. A balancing act: heterochromatin protein 1a and the Polycomb group coordinate their levels to silence chromatin in Drosophila (2015). Epigenetics and Chromatin 8:17. PMID: 25954320 Mulvey, B.B., Olcese, U., Cabrera, J. R. and Horabin, J. I. An Interactive network of long non-coding RNAs facilitates the Drosophila sex determination decision. (2014). Biochimica et Biophysica Acta Gene Reg. Mech. 1839L: 773–784. PMID: 24954180 Horabin, J. I. Long noncoding RNAs as metazoan developmental regulators (2013). Chromosome Res epub DOI 10.1007/s10577-013-9382-8. PMID: 24150236 Horabin, J. I. Balancing sex chromosone expression and satisfying the sexes. Fly 6(1). PMID: 22388008 Kappes, G., Deshpande, G., Mulvey, B. B., Horabin, J. I., & Schedl, P. (2011). The Drosophila Myc gene, diminutive, is a positive regulator of the Sex-lethal establishment promoter, Sxl-Pe. Proc Natl Acad Sci U S A, 108(4), 1543-8. Li, H., Rodriguez, J., Yoo, Y., Shareef, M. M., Badugu, R., Horabin, J. I., & Kellum, R. (2011). Cooperative and antagonistic contributions of two heterochromatin proteins to transcriptional regulation of the Drosophila sex determination decision. PLoS Genet, 7(6), e1002122. Gladstein, N., McKeon, M. N., & Horabin, J. I. (2010). Requirement of male-specific dosage compensation in Drosophila females – implications of early X chromosome gene expression. PLoS Genetics, 6 (7), e1001041. Walthall, S. L., Moses, M., & Horabin, J. I. (2007). A large complex with both Patched and Smoothened initiates Hedgehog signaling in Drosophila. J. Cell Science, 120, 826-837. Horabin, J. I. (2005). Splitting the Hedgehog signal: Sex and Patterning in Drosophila. Development, 132, 4801-4810. Horabin, J. I., Walthall, S., Vied, C., & Moses, M. (2003). A Positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal, the Drosophila Sex Determination Master Switch. Development, 130, 6101-6109. Vied. C., Halachmi, N., Salzberg, A., & Horabin, J. I. (2003). . Antizyme is a Target of Sex-lethal in the Drosophila Germline and appears to act downstream of Hedgehog to regulate Sex-lethal and Cyclin B. Developmental Biology, 253, 214-229. Vied, C., & Horabin, J. I. (2001). A new target for Hedgehog: the sex determination masterswitch, Sex-lethal, responds to Hedgehog signaling in the Drosophila germline. Development, 128, 2649-2660. Waterbury, J., Horabin, J. I., Bopp, D., & Schedl, P. (2000). Sex determination in the Drosphila germline is dictated by the sexual identity of the surrounding soma. Genetics, 155, 1741-1756. Bopp, D., Calhoun, G., Horabin, J. I., Samuels, M. E., & Schedl, P. (1996). Sex specific control of Sex-lethal is a common mechanism for sex determination in the Genus Drosophila. Development, 122, 971-982. Horabin, J. I., & Schedl, P. (1996). Splicing of the Drosophila Sex-lethal early transcripts involves exon skipping that is independent of Sex-lethal protein. RNA, 2, 1-10. Horabin, J. I., Bopp, D., Waterbury, J., & Schedl, P. (1995). Selection and Maintenance of Sexual Identity in the Drosophila germline. Genetics, 141, 1521-1535. Lantz, V., Chang, J., Horabin, J. I., Bopp, D., & Schedl, P. (1994). The Drosophila orb RNA-Binding Protein is required for the formation of the Egg Chamber and establishment of Polarity. Genes & Development, 8, 598-613. Horabin, J. I., & Schedl, P. (1993). Sex-lethal autoregulation requires multiple cis-acting elements upstream and downstream of the male exon and appears to pivot primarily on the male exon 5' splice site. Mol. Cell Biol, 13, 7734-7746. Bopp, D., Horabin, J. I., Lersch, R. A., Cline, T. W., & Schedl, P. (1993). . Expression of the Sex-lethal gene is controlled at multiple levels during Drosophila Oogenesis. Development, 118, 797-812. Horabin, J. I., & Schedl, P. (1993). Regulated splicing of the Drosophila Sex-lethal male exon involves a blockage mechanism. Mol. Cell Biol, 13, 1408-1414. Bell, L. R., Horabin, J. I., Schedl, P., & Cline, T. W. (1991). Positive Autoregulation of Sex-lethal by Alternative Splicing Maintains the Female Determined State in Drosophila. Cell, 65, 229-239.