个人简介

Ph.D., University of California at Berkeley

研究领域

Organic Chemistry and Biochemistry

Synthesis and uses of synthetic lipids. See website for additional information. - See more at: http://www.gc.cuny.edu/Page-Elements/Academics-Research-Centers-Initiatives/Doctoral-Programs/Chemistry/Faculty-Bios/Robert-Bittman#sthash.yTOQzI1s.dpuf

近期论文

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F. Tonelli, K. G. Lim, C. Loveridge, J. Long, S. M. Pitson, G. Tigyi, R. Bittman, S. Pyne, and N. J. Pyne, “FTY720 and (S)-FTY720 Vinylphosphonate Inhibit Sphingosine Kinase 1 and Promote Its Proteasomal Degradation in Human Pulmonary Artery Smooth Muscle, Breast Cancer, and Androgen-independent Prostate Cancer Cells,” Cell. Signal. 22, 1536-1542 (2010). S. Pyne, R. Bittman, and N. J. Pyne, “Sphingosine Kinase Inhibitors and Cancer: Seeking the Golden Sword of Hercules,” Cancer Res. 71, 6576-6582 (2011). K. G. Lim, F. Tonelli, Z. Li, X. Lu, R. Bittman, S. Pyne, and N. J. Pyne, “FTY720 Analogues as Sphingosine Kinase 1 Inhibitors: Enzyme Inhibition Kinetics, Allosterism, Proteasomal Degradation, and Actin Rearrangement in MCF-7 Breast Cancer Cells,” J. Biol. Chem. 286, 18633-18640 (2011). K. G. Lim, C. Sun, R. Bittman, N. J. Pyne, and S. Pyne, “(R)-FTY720 Methyl Ether Is a Specific Sphingosine Kinase 2 Inhibitor: Effect on Sphingosine Kinase 2 Expression in HEK293 Cells and Actin Rearrangement and Survival of MCF-7 Breast Cancer Cells,” Cell. Signal. 23, 1590-1595 (2011). K. G. Lim, F. Tonelli, E. Berdyshev, I. Gorshkova, T. Leclercq, S. M. Pitson, R. Bittman, S. Pyne, and N. J. Pyne, “Inhibition Kinetics and Regulation of Sphingosine Kinase 1 Expression in Prostate Cancer Cells: Functional Differences between Sphingosine Kinase 1a and 1b,” Int. J. Biochem. Cell Biol. 44, 1457-1464 (2012). F. Tonelli, M. Alossaimi, L. Williamson, R. J. Tate, D. G. Watson, E. Chan, R. Bittman, N. J. Pyne, and S. Pyne, “The Sphingosine Kinase Inhibitor 2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole Reduces Androgen Receptor Expression via an Oxidative Stress Dependent Mechanism,”,Br. J. Pharmacol. 168, 1497-1505 (2013). D. J. Baek, N. MacRitchie, S. Pyne, N. J. Pyne, and R. Bittman, “Synthesis of Selective Inhibitors of Sphingosine Kinase 1,” Chem. Commun. 49, 2136-2138 (2013). D. G. Watson, F. Tonelli, M. Alossaimi, L. Williamson, E. Chan, I. Gorshkova, E. Berdyshev, R. Bittman, N. J. Pyne, and S. Pyne, “The Roles of Sphingosine Kinase 1 and 2 in Regulating the Warburg Effect in Prostate Cancer Cells,” Cell. Signal. 25, 1011-1017 (2013). Z. Liu, N. MacRitchie, S. Pyne, N. J. Pyne, and R. Bittman, “Synthesis of (S)-FTY720 Vinylphosphonate Analogues and Evaluation of Their Potential as Sphingosine Kinase 1 Inhibitors and Activators,” Bioorg. Med. Chem. 21, 2503-2510 (2013). R. S. Lankalapalli, A. Ouro, L. Arana, A. Gómez Muñoz, and R. Bittman, “Caged Ceramide 1-Phosphate Analogues: Synthesis and Properties,” J. Org. Chem. 74, 8844-8847 (2009). Y. A. Kim, D. M. Carter Ramirez, W. J. Costain, L. J. Johnston, and R. Bittman, “A New Tool to Assess Ceramide Bioactivity: 6-Bromo-7-hydroxycoumarinyl-Caged Ceramide,” Chem. Commun. 47, 9236-9238 (2011). L. Arana, P. Gangoiti, A. Ouro, I. G. Rivera, M. Ordoñez, M. Trueba, R. S. Lankalapalli, R. Bittman, and A. Gomez-Muñoz, “Generation of Reactive Oxygen Species (ROS) Is a Key Factor for Stimulation of Macrophage Proliferation by Ceramide 1-Phosphate,” Exp. Cell Res. 318, 350-360 (2012). A.Ouro, L. Arana, P. Gangoiti, I. G. Rivera, M. Ordoñez, M. Trueba, R. S. Lankalapalli, R. Bittman, and A. Gomez-Muñoz, “Ceramide 1-Phosphate Stimulates Glucose Uptake in Macrophages,” Cell. Signal. 25, 786-795 (2013). D. M. Carter Ramirez, S. P. Pitre, Y. A. Kim, R. Bittman, and L. Johnston, “Photouncaging of Ceramides Promotes Reorganization of Liquid-Ordered Domains in Supported Lipid Bilayers,” Langmuir 29, 338-347 (2013). D. M. Carter Ramirez, Y. A. Kim, R. Bittman, and L. Johnston, “Lipid Phase Separation and Protein-Ganglioside Clustering in Supported Bilayers Are Induced by Photorelease of Ceramide,” Soft Matter 9, 4890-4899 (2013) R. D. Singh, Y. Liu, C. L. Wheatley, E. L. Holicky, A. Makino, D. L. Marks, T. Kobayashi, G. Subramaniam, R. Bittman, and R. E. Pagano, “Caveolar Endocytosis and Microdomain Association of a Glycosphingolipid Analog Is Dependent On Its Sphingosine Stereochemistry,” J. Biol. Chem. 281, 30660-30668 (2006). R. D. Singh, E. L. Holicky, Z-J. Cheng, S. Y. Kim, C. L. Wheatley, D. L. Marks, R. Bittman, and R. E. Pagano, “Inhibition of Caveolar Uptake, SV40 Infection, and β1-Integrin Signaling by a Nonnatural Glycosphingolipid Stereoisomer,” J. Cell Biol. 176, 895-901 (2007). D. L. Marks, R. Bittman, and R. E. Pagano, “Use of Bodipy-labeled Sphingolipid and Cholesterol Analogs to Examine Membrane Microdomains in Cells,” in special issue on Focus on Molecular Imaging, Histochem. Cell Biol. 130, 819-832 (2008). P. Bandhuvula, Z. Li, R. Bittman, and J. D. Saba, “Sphingosine 1-Phosphate Lyase Enzyme Assay using a BODIPY-labeled Substrate,” Biochem. Biophys. Res. Commun. 380, 366-370 (2009). M. Jansen, Y. Ohsaki, L. R. Rega, R. Bittman, V. M. Olkkonen, and E. Ikonen, “Role of ORPs in Sterol Transport from Plasma Membrane to ER and Lipid Droplets in Mammalian Cells,” Traffic 12, 218-231 (2011).