个人简介

Mark Biscoe was raised in Bristol, CT. In 1999, he received a B.A. degree in chemistry from Wesleyan University where he conducted research in the laboratory of Albert J. Fry. In 2005, Mark received his Ph.D. from Columbia University under the guidance of Ronald Breslow. After three years as an NIH postdoctoral fellow in the laboratory of Stephen Buchwald at MIT, Mark joined the faculty of the City College of New York in 2009 as an assistant professor of chemistry. In 2016, he was promoted to the rank of associate professor with tenure.

研究领域

Organic and Inorganic Chemistry

Broadly, research in the Biscoe lab focuses on catalysis. The two major types of catalysis in which we are interested are transition metal catalysis and macromolecular catalysis. Our primary research goals involve the development of practical and reliable processes for the construction of C-C and C-X (X = heteroatom) bonds. We are particularly interested in the development of new processes for the formation of common structural motifs of importance in medicinal chemistry and drug discovery.

近期论文

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Zhao, Shibin: Gensch, Tobias; Murray, Benjamin; Niemeyer, Zachary L.; Sigman, Matthew S.*; Biscoe, Mark R.* "Enantiodivergent Pd-Catalyzed C–C Bond Formation Enabled through Ligand Parameterization." Science 2018, DOI: 10.1126/science.aat2299 pdf link 22. Ma, Xinghua; Diane, Mohamed; Ralph, Glenn; Chen, Christine; Biscoe, Mark R.* "Stereospecific Electrophilic Fluorination of Alkylcarbastannatrane Reagents." Angew. Chem. Int. Ed. 2017, 56, 12663-12667. pdf link 21. Wang, Chao-Yuan; Ralph, Glenn; Derosa, Joseph; Biscoe, Mark R.* "Stereospecific Pd-Catalyzed Acylation of Alkylcarbastannatrane Reagents: A General Alternative to Asymmetric Enolate Reactions." Angew. Chem. Int. Ed. 2017, 56, 856-860. [Highlighted in: Synfacts 2017, 258] pdf link 20. Wang, Chao-Yuan; Derosa, Joseph; Biscoe, Mark R.* "The Use of Stable, Optically Active Organometallic Nucleophiles in Cross-Coupling Reactions: A New Approach to Asymmetric Synthesis." Chem. Sci. 2015, 6, 5105-5113. pdf link 19. Li, Ling; Zhao, Shibin; Joshi-Pangu, Amruta; Diane, Mohamed; Biscoe, Mark R.* "Stereospecific Pd-Catalyzed Cross-Coupling Reactions of Secondary Alkylboron Nucleophiles and Aryl Chlorides." J. Am. Chem. Soc. 2014, 136, 14027-14030. pdf link 18. Li, Ling; Wang, Chao-Yuan; Huang, Rongcai; Biscoe, Mark R.* "Stereoretentive Pd-Catalyzed Stille Cross-Coupling Reactions of Secondary Alkyl Azastannatranes and Aryl Electrophiles." Nature Chem. 2013, 5, 607-612. [Highlighted in: Synfacts 2013, 100] pdf link 17. Li, Ling; Biscoe, Mark R.* "Alkylzinc Cross-Coupling Reactions." In Cross-Coupling and Heck-Type Reactions, Vol. 1; Molander, G., Ed.; Georg Thieme Verlag HG: Stuttgart, 2013, pp 795-837. 16. Joshi-Pangu, Amruta; Ma, Xinghua; Diane, Mohammed; Iqbal, Sidra; Kribs, Robert J.; Huang, Richard; Wang, Chao-Yuan; Biscoe, Mark R.* "Palladium-Catalyzed Borylation of Primary Alkyl Bromides." J. Org. Chem. 2012, 77, 6629-6633. pdf link 15. Joshi-Pangu, Amruta; Biscoe, Mark R.* "The Use of Teriary Alkyl Nucleophiles in Metal-Catalyzed Cross-Coupling Reactions." Synlett 2012, 23, 1103-1107. [Synpact article: invited review highlighting work in pub. 14] pdf link 14. Joshi-Pangu, Amruta; Wang, Chao-Yuan; Biscoe, Mark R.* “Nickel-Catalyzed Kumada Cross-Coupling Reactions of Tertiary Alkylmagnesium Halides and Aryl Bromides/Triflates.” J. Am. Chem. Soc. 2011, 133, 8478-8481. [Highlighted in: Synfacts 2011, 897] pdf link 13. Joshi-Pangu, Amruta; Ganesh, Madhu; Biscoe, Mark R.* “Nickel-Catalyzed Negishi Cross-Coupling Reactions of Secondary Alkylzinc Halides and Aryl Iodides.” Org. Lett. 2011, 13, 1218-1221. [Highlighted in: Synfacts 2011, 662] pdf link 12. Biscoe, Mark R.; Buchwald, Stephen L. “The Selective Monoarylation of Acetate Esters and Aryl Methyl Ketones Using Aryl Chlorides.” Org. Lett. 2009, 11, 1773-1775. pdf link 11. Lee, Brian K.; Biscoe, Mark R.; Buchwald, Stephen L. “Simple, Efficient Protocols for the Pd-Catalyzed Cross-Coupling Reaction of Aryl Chlorides and Dimethylamine.” Tetrahedron Lett. 2009, 50, 3672-3674 [50th anniversary special issue]. pdf link 10. Fors, Brett P.; Watson, Donald A.; Biscoe, Mark R.; Buchwald, Stephen L. “A Highly Active Catalyst for Pd-Catalyzed Amination Reactions: Cross-Coupling Reactions Using Aryl Mesylates and the Highly Selective Monoarylation of Primary Amines.” J. Am. Chem. Soc. 2008, 130, 13552-13554. pdf link 9. Biscoe, Mark R.; Fors, Brett P.; Buchwald, Stephen L. “A New Class of Easily Activated Palladium Precatalysts for Facile C–N Cross-Coupling Reactions and the Low Temperature Oxidative Addition of Aryl Chlorides.” J. Am. Chem. Soc.2008, 130, 6686-6687. [Featured as Editor’s Choice in: Science 2008, 320, 850-851] pdf link 8. Biscoe, Mark R.; Barder, Timothy E.; Buchwald, Stephen L. “Electronic Effects on the Selectivity of Pd-Catalyzed C–N Bond-Forming Reactions Using Biarylphosphine Ligands: The Competitve Roles of Amine Binding and Acidity.” Angew. Chem. Int. Ed. 2007, 46, 7232-7235. pdf link 7. Ikawa, Takashi; Barder, Timothy E.; Biscoe, Mark R.; Buchwald, Stephen L. “Pd-Catalyzed Amidations of Aryl Chlorides Using Monodentate Biaryl Phosphine Ligands: A Kinetic, Computational, and Synthetic Investigation.” J. Am. Chem. Soc. 2007, 129, 13001-13007. pdf link