Sacchetti, Paola - University of Hartford

研究领域

My research focuses on neuroscience and molecular biology. I study how transcription factors control expression of genes important for the development of brain cells. In particular I focus on dopamine neurons, the cells that die in patients affected by Parkinson's disease. My aim is to understand how normal cells develop and which genes and regulators are essential for the life of dopamine cells in order to better understand what happens during the disease state. I am also interested in other neurodegenerative disorders, in particular dementia. I am currently investigating the biology of concussions and I am interested in designing educational tools to inform the community about manifestation, short-term and long-term consequences of mild traumatic brain injury.

近期论文

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Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis. Theofilopoulos S, Wang Y, Kitambi SS, Sacchetti P, Sousa KM, Bodin K, Kirk J, Saltó C, Gustafsson M, Toledo EM, Karu K, Gustafsson JÅ, Steffensen KR, Ernfors P, Sjövall J, Griffiths WJ, Arenas E. Nat Chem Biol. 2013 Feb;9(2):126-33. doi: 10.1038 Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells. Sacchetti P, Sousa KM, Hall AC, Liste I, Steffensen KR, Theofilopoulos S, Parish CL, Hazenberg C, Richter LA, Hovatta O, Gustafsson JA, Arenas E. Cell Stem Cell. 2009 Oct 2;5(4):409-19. doi: 10.1016 Targeted lipidomic analysis of oxysterols in the embryonic central nervous system. Wang Y, Sousa KM, Bodin K, Theofilopoulos S, Sacchetti P, Hornshaw M, Woffendin G, Karu K, Sjövall J, Arenas E, Griffiths WJ. Mol Biosyst. 2009 May;5(5):529-41. doi: 10.1039 CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in neural stem cells. Andersson T, Södersten E, Duckworth JK, Cascante A, Fritz N, Sacchetti P, Cervenka I, Bryja V, Hermanson O. J Biol Chem. 2009 Feb 6;284(6):3672-81. doi: 10.1074 The glucocorticoid receptor is a co-regulator of the orphan nuclear receptor Nurr1. Carpentier R, Sacchetti P, Ségard P, Staels B, Lefebvre P. J Neurochem. 2008 Feb;104(3):777-89. Multiple signaling pathways regulate the transcriptional activity of the orphan nuclear receptor NURR1.Sacchetti P, Carpentier R, Ségard P, Olivé-Cren C, Lefebvre P. Nucleic Acids Res. 2006;34(19):5515-27. Candida albicans phospholipomannan is sensed through toll-like receptors. Jouault T, Ibata-Ombetta S, Takeuchi O, Trinel PA, Sacchetti P, Lefebvre P, Akira S, Poulain D. J Infect Dis. 2003 Jul 1;188(1):165-72.