Li, Yingcui - University of Hartford

研究领域

Yingcui Li's research is on genes and development. As a developmental biologist and cartilage biologist, her research has been focused on function of Hyaluronan, a large molecular made by cartilage cells, for limb and synovial joint development. Recently, she has developed transgenic mouse models for the genetic analysis of Hyaluronan function in Osteoarthritis. The general goal of her research is to provide insight into new targets and reveal new approaches for Osteoarthritis treatment, including novel drug target or gene therapy.

近期论文

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Dyment N, Hagiwara Y, Mattews B, Li Y, Kalajzic I, Rowe D. 2014. Lineage tracing of progenitor cells that contribute to distinct regions of tendons during growth and natural healing. PLoS ONE, in Press. Li Y, Fisher M, Shepard J, Iwamoto R, Dealy C. 2013. EGFR signals are negative regulators of chondrocyte maturation. Manuscript in Preparation. Fisher M, Ferrari D, Li Y, Shepard JB, Patterson S, Anderson N, Dealy CN. 2012. The potential of human embryonic stem cells for articular cartilage repair and osteoarthritis: A review. Rheumatology Current Research. S3:1-10. Liu Y, Wang L, Fatahi R, Kronenberg M, Kalajzic I, Rowe D, Li Y, Maye P. 2010. Isolation of murine bone marrow derived mesenchymal stem cells using Twist2 Cre transgenic mice. Bone. 47:916-925. Matsumoto K,*, Li Y* (co-first authors), Jakuba C, Sugiyama Y, Sayo T, Okuno M, Dealy CN, Toole BP, Takeda J, Yamaguchi Y, Kosher RA. Conditional Inactivation of Has2 Reveals a Crucial Role for Hyaluronan in Skeletal Growth, Patterning, Chondrocyte Maturation, and Joint Formation in the Developing Limb. 2009. Development. 136(16):2825-35. Li Y, Toole BP, Dealy CN, Kosher RA. Hyaluronan in Limb Morphogenesis. 2007. Developmental Biology. 305(2): 411-20. NOTE: Selected as a "Must Read" in Faculty of 1000 Biology. Chin H, Fisher M, Li Y, Ferrari D, Wang C, Lichtler A, Dealy CN, Kosher RK. Studies on the role of Dlx5 in regulation of chondrocyte differentiation during endochondral ossification in the developing mouse limb. 2007. Development, Growth and Differentiation. 49(6): 515-521. Fisher M, Li Y, Seghatoleslami MR, Dealy CN, Kosher RA. Heparan sulfate proteoglycans including syndecan-3 modulate BMP activity during limb cartilage differentiation. 2006. Matrix Biology. 25(1): 27-39.