Dyke, Aaron Van - Fairfield University - Chemistry & Biochemistry

个人简介

A native of the pacific northwest, Aaron Van Dyke received his B.S. in Chemistry from Seattle University (a fellow Jesuit Institution) as a Sullivan Scholar. He went on to the Massachusetts Institute of Technology, earning a Ph.D. in Organic Chemistry. Working under Professor Timothy F. Jamison, Dr. Van Dyke developed methods for the synthesis of ladder polyether natural products. He then entered the field of Chemical Biology, training with Professor Anna K. Mapp at the University of Michigan as an American Cancer Society – Michigan Cancer Research Fund postdoctoral fellow. Professor Van Dyke began his independent career at Fairfield University in 2013. He was recognized as Fairfield University's Undergraduate Teacher of the Year in 2015 and received the College of Arts and Sciences Distinguished Advising and Mentoring Award in 2017. He currently serves on the National Selection Committee for the Barry M. Goldwater Scholarship and is the Faculty-in-Residence of Fairfield's Ignatian Residential College.

研究领域

As a Chemical Biology group, my research is situated at the interface of chemistry and biology. Projects in my group revolve around small molecules that modify protein structure and/or function. Areas of active reserach involve 1) investigating new bioorthogonal strategies for covalently labeling native proteins and 2) designing small molecules to control transcriptionally important protein-protein interactions.

近期论文

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Van Dyke, A. R.; Smith-Carpenter, J. Bring Your Own Device: A Digital Notebook for Undergraduate Biochemistry Laboratory Using a Free, Cross-Platform Application. J. Chem. Educ. 2017, 94, 656–661. Kubasik, M. A.; Van Dyke, A. R.; Harper-Leatherman, A. S.; Miecznikowski, J. R.; Steffen, L. K.; Smith-Carpenter, J. A cloud-based scavenger hunt: Orienting undergraduates to ACS national meetings. J. Chem. Educ. 2016, 93, 1957–1960. Van Dyke, A. R.; Etemad, L. S.; Vessicchio, M. J.; Naclerio, G. A.; Jedson, T. E. Capture-Tag-Release: A strategy for small molecule labeling of native enzymes. ChemBioChem 2016, 17, 1602–1605. Højfeldt, J.W.; Cruz, O.; Imaeda, Y.; Van Dyke, A. R.; Carolan, J.P.; Mapp, A.K.; Iniguez, J. Bifunctional Ligands Allow Deliberate Extrinsic Reprogramming of the Glucocorticoid Receptor. Mol. Endocrinol. 2014, 28, 249–259. Merrins, M.J.; Van Dyke, A. R.; Mapp, A. K.; Rizzo, M. A.; Satin, L. S. Direct measurements of oscillatory glycolysis in pancreatic islet b-cells using novel fluorescence resonance energy transfer (FRET) biosensors for pyruvate kinase M2 activity. J. Biol. Chem. 2013, 288, 33312–33322. Højfeldt, J. W.; Van Dyke, A. R.; Mapp, A. K. Transforming ligands into transcriptional regulators: Building blocks for bifunctional molecules. Chem. Soc. Rev. 2011, 40, 4286–4294. Morten, C. J.; Byers, J. A.; Van Dyke, A. R.; Vilotijevic, I.; Jamison, T. F. The development of endo-selective epoxide-opening cascades in water. Chem. Soc. Rev. 2009, 38, 3175–3192. Van Dyke, A. R.; Jamison, T. F. Functionalized templates for the convergent assembly of polyethers: Synthesis of HIJK rings of gymnocin A. Angew. Chem. Int. Ed. 2009, 48, 4430–4432. Van Dyke, A. R.; Jamison, T. F. [(1S,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl] diphenylphosphine. In Encyclopedia of Reagents for Organic Synthesis, Second Edition; Paquette, L. A., Crich, D., Fuchs, P. L., Molander, G., Eds.; Wiley: Hoboken, 2009. Van Dyke, A. R.; Miller, K. M.; Jamison, T. F. (S)-(+)-Neomenthyldiphenylphosphine in nickel-catalyzed asymmetric reductive coupling of alkynes and aldehydes: Enantioselective synthesis of allylic alcohols and a-hydroxyketones. Org. Synth. 2007, 84, 111–119. Blice-Baum, A.; Van Dyke, A. R.; Sigmon, I.; Salter, A.; Wierzbicki, A.; Pocker, Y.; Spyridis, G. T. Computational and spectroscopic studies concerning the solvatochromic behavior of 1,3-disubstituted azulenes. Int. J. Quant. Chem. 2006, 106, 2331–2338.