郭键 - 重庆大学 - 药学院(创新药物研究中心)

个人简介

郭键，2012年6月毕业于北京大学药学院，获得博士学位。先后主持、参与国家自然基金、重庆市自然基金、新药创制重大专项等项目多项，已在J. Med. Chem., Org. Lett.等药物化学、有机化学领域国际权威期刊上发表SCI论文近二十篇，申请专利多项。

研究领域

新型靶向抗生素及抗菌新策略的研发；基于“糖”的药物化学及化学生物学研究。

近期论文

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Lagishetti, C.; Banne, S.; You, H.;Tang, M.; Guo, J.*; Qi, N.*; He, Y.* Construction of Bridged-Ring-Fused Naphthalenone Derivatives Through an Unexpected Zn(OTf)2-Catalyzed Cascade Transformation. Org. Lett. 2019, 21, 5301-5304. Liu, Y.; Wang, Z.-P.; Banne, S.; Guo, J.*; He, Y. * Toward the Total Synthesis of Scabrosins: Synthesis of a Desulfur-scabrosin Skeleton and Its Stereoisomers. J. Org. Chem. 2019, 84, 5838-5845. Lin, Z.; Xu, X.; Zhao, S.; Yang, X.; Guo, J.; Zhang, Q.; Jing, C.; Chen, S.; He, Yun, Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens. Nat. Commun. 2018, 9, 3445. Banne, S.; Reddy, D. P.; Li, W.; Wang, C.; Guo, J.*; He, Y.* A Unified Modular Synthetic Strategy for Dictyodendrins F, H, I, and G. Org. Lett. 2017, 19, 4996–4999. Xu, X.-B.; Lin, Z.-H.; Liu, Y.; Guo, J.*; He, Y.* Stevens rearrangement of thioethers with arynes: a facile access to multi-substituted β-keto thioethers. Org. Biomol. Chem., 2017, 15, 2716-2720. Guo, J.; Li, W.; Xue, W.; Ye, X.-S.* Transition State-Based Sialyltransferase Inhibitors: Mimicking Oxocarbenium Ion by Simple Amide. J. Med. Chem. 2017, 60, 2135–2141. Qi, N.; Zhang, N.; Allu, S. R.; Gao, J.; Guo, J.*; He, Y.* Insertion of Arynes into P–O Bonds: One-Step Simultaneous Construction of C–P and C–O Bonds. Org. Lett.2016, 18, 6204-6207. Qi, N.; Allu, S. R.; Wang, Z.; Liu, Q.; Guo, J.*; He, Y.* Asymmetric Total Syntheses of Aetheramides and Their Stereoisomers: Stereochemical Assignment of Aetheramides. Org. Lett. 2016, 18, 4718-4721. Guo, J.#; Kiran, I. C.#; Reddy, R. S.; Gao, J.; Tang, M.; Liu, Y.; He, Y.* Synthesis of Carbazolequinones by Formal [3+ 2] Cycloaddition of Arynes and 2-Aminoquinones. Org. Lett. 2016, 18, 2499-2502. Qi, N.; Wang, Z.; Allu, S. R.; Liu, Q.; Guo, J.*; He, Y.* Total Syntheses of Anti-HIV Cyclodepsipeptides Aetheramides A and B. J. Org. Chem. 2016, 81, 12466-12471. Guo, J.; He, Y.*; Ye, X.-S.* Design and Discovery of Sialyltransferase Inhibitors. Prog. Chem. 2016, 28, 1712-1720.