田津斌 - 重庆大学 - 药学院(创新药物研究中心)

个人简介

学历博士（1995.9-1998.6）：北京医科大学，神经科学研究所，神经生理学专业，指导老师：韩济生院士研究领域：神经化学，中枢神经递质释放的电针频率响应性硕士（1992.9-1995.6）：北京师范大学，生物学系和北京医科大学，神经科学研究所，联合培养，人体及动物生理学专业，指导老师：魏开元教授，韩济生院士研究领域：中枢神经肽在电针镇痛中的作用本科（1988.9-1992.6）：天津师范大学，生物学系，生物学专业工作经验 2018.06-至今：重庆大学药学院，药理学系，预聘制副教授 2010.10-2018.06：美国德州大学休斯顿医学院，生物学及药理学系，助理教授 (Assistant Professor) 2005.10-2010.09：美国俄亥俄州立大学，神经科学系，神经电生理中心实验室主管科学家（Manager，Research Scientist） 1999.10-2005.09：美国俄亥俄州立大学，神经科学系，博士后 1998.12-1999.09：美国纽约州立大学，布鲁克林健康科学中心，生物化学系，博士后专业书籍章节 Bavencoffe, A., Zhu, M.X., Tian, J.B. New Aspects of the Contribution of ER to SOCE Regulation: TRPC Proteins as a Link Between Plasma Membrane Ion Transport and Intracellular Ca2+ Stores. Adv Exp Med Biol. 993:239-255, 2017, PMID: 28900918. Tian, J. B. *, Thakur, D., Lu, Y. and Zhu, M. X.: TRPC channels. In Handbook of Ion Channels. J. Zheng and M. C. Trudeau. Eds. Chapter 27:411-426, CRC Press, 2015. Miller, M. R., Shi, J., Wu, M., Engers, J., Hopkins, C. R., Lindsley, C. W., Salovich, J. M., Zhu, Y., Tian, J. B., Zhu, M.X., McManus, O.B., Li, M.: Novel Chemical Inhibitor of TRPC4 Channels. In Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD): National Center for Biotechnology Information (US), Chapter ml204, 2010. PMID: 22049577

研究领域

神经化学，中枢神经递质释放的电针频率响应性

近期论文

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发表科研论文（一）国际期刊 Ding, M., Wang, H., Qu, C., Xu, F., Zhu, Y., Lv, G., Lu, Y., Zhou, Q., Zhou, H., Zeng, X., Zhang, J., Yan. C., Lin, J., Luo, H.R., Deng, Z., Xiao, Y., Tian, J., Zhu, M.X., Hong, X.: Pyrazolo[1,5-a]pyrimidine TRPC6 Antagonists for the Treatment of Gastric Cancer. Cancer Lett. 432:47-55，2018. PMID: 29859875. Qu, C., Ding, M., Zhu, Y., Lu, Y., Du, J., Miller, M.R., Tian, J., Zhu. J., Xu, J., Wen, M, Er-Bu, A., Wang, J., Xiao, Y., Wu, M., McManus, O.B., Li, M., Wu, J., Luo, H.R., Cao, Z.Y., Shen, B., Wang, H., Zhu, M.X., Hong, X.: Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels. J Med Chem. 60:4680-4692, 2017. PMID: 28395140. Li, Y., Hu, H., Tian, J.B., Zhu, M.X., O'Neil, R.G.: Dynamic coupling between TRPV4 and Ca-activated SK1/3 and IK1 K channels plays a critical role in regulating the K secretory BK channel in collecting duct cells. Am J Physiol Renal Physiol. 312:F1081-F1089, 2017. PMID: 28274924. Ramot, A., Jiang, Z., Tian, J.B., Nahum, T., Kuperman, Y. Justice, N.J., Chen, A.: Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress. Nat. Neurosci. 20:385-388, 2017. PMID: 28135239. Li, Y., Hu, H., Butterworth, M.B., Tian, J.B., Zhu, M.X., O'Neil, R.G.: Expression of a Diverse Array of Ca2+-Activated K+ Channels (SK1/3, IK1, BK) that Functionally Couple to the Mechanosensitive TRPV4 Channel in the Collecting Duct System of Kidney. PLoS One. 11:e0155006, 2016. PMID: 27159616. Jeon, J.P., Thakur, D.P., Tian, J.B., So, I., Zhu, M,X,: Regulator of G protein signaling and GoLoco proteins suppress TRPC4 channel function via acting at Galphai/o. Biochem. J. 473:1379-1390, 2016 PMID: 26987813 Thakur, D. P., Tian, J., Jeon, J., Xiong, J., Huang, Y., Flockerzi, V., Zhu, M. X.: Critical roles of Gi/o proteins and phospholiapse C-δ1 in the activation of receptor-operated TRPC4 channels. Proc. Natl. Acad. Sci. USA. 113:1092-1097, 2016. PMID: 26755577. Gao, L., Yang, P., Qin, P., Lu, Y., Li, X., Tian, Q., Li, Y., Xie, C., Tian, J.B., Zhang, C., Tian, C., Zhu, M.X., Yao, J.: Selective potentiation of 2-APB-induced activation of TRPV1-3 channels by acid. Sci Rep. 6:20791, 2016. PMID: 26876731. Tian, J. *, Thakur, D. P., Lu, Y., Zhu, Y., Freichel, M., Flockerzi, V., and Zhu, M. X.: Dual depolarization responses generated within the same lateral septal neurons by TRPC4-containing channels. Pflugers Arch. 466:1301-1316, 2014. PMID: 24121765 Justice, N. J., Huang, L., Tian, J.B., Cole, A., Pruski, M., Hunt, A. J., Flores, R., Zhu, M. X., Arenkiel, B. R., and Zheng, H.: Posttraumatic Stress Disorder-Like Induction Elevates β-Amyloid Levels, Which Directly Activates Corticotropin-Releasing Factor Neurons to Exacerbate Stress Responses. J Neurosci. 35:2612-2623, 2015. PMID: 25673853 Zhu, Y., Lu, Y., Qu, C., Miller, M., Tian, J., Zhu, J., Deng, Z., Hu, X., Wu, M., McManus, O., Li, M., Hong, X., Zhu, M., and Luo, H.: Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br. J. Pharmacol. 172:3495-3509, 2015. PMID: 25816897. Tian, J. *, Tep, C., Benedick, A., Saidi, N., Ryu, J. C., Kim, M. L., Sadasivan, S., Oberdick, J., Smeyne, R., Zhu, M.X. and Yoon, S.O.: P75 regulates Purkinje cell firing by modulating SK channel activity through Rac1. J. Biol. Chem. 289:31458-31472, 2014. PMID: 25253694. Tian, J. *, Tep, C., Zhu, M. X. and Yoon, S. O.: Changes in Spontaneous Firing Patterns of Cerebellar Purkinje Cells in p75 Knockout Mice. Cerebellum. 12:300-303, 2013. PMID: 23307658