李葆生 - 重庆大学 - 化学化工学院

个人简介

2016年任特聘研究员、博士生导师。2013年博士毕业于兰州大学（导师：曹小平教授；涂永强院士）， 2012年至2013年在香港中文大学做研究助理（导师： Hak-Fun Chow 教授），2013年至2016年在新加坡南洋理工大学从事博士后研究（导师： Robin Chi 教授），2017年入选“青年人才托举工程”人才计划。目前主持“青年人才托举工程”人才项目经费、国家自然科学基金面上项目、重庆大学科研启动基金。迄今以在国际主流期刊Nature Communications、JACS、Chemical Science等杂志上发表学术论文20余篇。主要从事活性化合物的合成，有机合成方法学的发展，化学生物学等方面的研究。教育背景 2008-2013 博士兰州大学化学化工学院有机合成 (导师：涂永强院士；曹小平教授) 2004-2008 学士贵州大学化学化工学院制药工程工作经历 2016-至今特聘研究员重庆大学化学化工学院 2013-2016 博后新加坡南洋理工大学化生系 (导师: Robin Chi 教授) 2012-2013 研究助理香港中文大学，化学院 (导师: Hak-Fun Chow 教授)

研究领域

1.有机合成方法学的发展 2. 药物分子、活性化合物的合成及生物活性研究 3. 小分子靶向药物的合成及其在肿瘤诊疗和转化医学等领域中的应用

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

7. Carbene-catalyzed reductive coupling of nitrobenzyl bromides and ketones via single-electron-transfer process. Bao-Sheng Li; Yuhuang, Wang; Rupert S. J. Proctor; Yuexia Zhang; Richard D. Webster; Song Yang; Baoan Song; Yonggui Robin Chi*, Nature Communications. 2016, 7, in press. 6. Carbene-catalyzed desymmetrization of 1,3-diols: access to optically enriched tertiary alkyl chlorides. Bao-Sheng Li; Yuhuang, Wang; Rupert S. J. Proctor; Zhichao, Jin; Yonggui Robin Chi*, Chem. Commun, 2016, 52, 8313. 5. Carbon–carbon bond activation of cyclobutenones enabled by the addition of chiral organocatalyst to ketone. Bao-Sheng, Li; Yuhuang Wang, Zhichao Jin, Pengcheng Zheng, Rakesh Ganguly & Yonggui Robin Chi*, Nature Communications. 2015, 6, 6207. 4. Cycloaddition of cyclobutenone and azomethine imine enabled by chiral isothiourea organic catalysts. Bao-Sheng Li, Yuhuang Wang, Zhichao Jin and Yonggui Robin Chi*, Chemical Science, 2015, 6, 6008. 3. Direct Synthesis of Spiro- and Fused-Hydrofurans via Tunable Tandem Semipinacol Rearrangement/Oxa-Michael Addition. Bao-Sheng, Li; Wen-Xing, Liu; Fu-Min, Zhang; Shao-hua, Wang; Yong-Qiang, Tu*; Xiao-Ping, Cao*,Chenistry - A European Journal, 2013, 19, 5246. 2. Copper(I)-catalyzed Intramolecular [2 + 2] Cycloaddition of 1,6-enyne-derived Ketenimine: an Efficient Construction of Strained and Bridged 7-substituted-3- Heterobicyclo[3.1.1]heptan-6-one. Bao-Sheng Li; Bin-Miao, Yang; Shao-Hua, Wang; Yong-Qiang, Zhang; Xiao-Ping, Cao*; Yong-Qiang, Tu*, Chemical. Science., 2012, 3, 1975.Highlighted by Synfacts, 2012, 8, 0868. 1. One-Pot Construction of Multi-Substituted Spiro-Cycloalkanediones by an Organocatalytic Asymmetric Epoxidation/Semipinacol Rearrangement. Bao-Sheng, Li; En, Zhang; Qing-Wei, Zhang; Fu-Min, Zhang; Yong-Qiang, Tu*; Xiao-Ping Cao*, Chem–Asian. J., 2011, 6, 2269. 8. Access to P-Stereogenic Phosphinates via N-Heterocyclic Carbene-Catalyzed Desymmetrization of Bisphenols. Zhijian Huang, Xuan Huang, Baosheng Li, Chengli Mou, Song Yang, Bao-An Song, and Yonggui Robin Chi. J. Am. Chem. Soc., 2016, 138, 7524. 7. N-Heterocyclic Carbene-Catalyzed δ-Carbon LUMO Activation of Unsaturated Aldehydes.. Tingshun Zhu, Chengli Mou, Baosheng Li, Marie Smetankova, Bao-An Song, and Yonggui Robin Chi*, J. Am. Chem. Soc., 2015, 137, 5658. 6. Catalytic asymmetric semipinacol rearrangements. Shao-Hua Wang, Bao-Sheng Li and Yong-Qiang Tu, Chem. Commun., 2014, 50, 2393. 5. Construction of fused- and spiro-oxa-[n.2.1] skeletons by a tandem epoxide rearrangement/intramolecular [3+2] cycloaddition of cyclopropanes with carbonyls. Lu-Feng Wang, Zi-Fa Shi, Xiao-Ping Cao*, Bao-Sheng Li and Peng An. Chem. Commun., 2014, 50, 8061. 4. Catalytic intermolecular carbon electrophile induced semipinacol rearrangement. Qing-Wei Zhang, Xiao-Bo Zhang, Bao-Sheng Li, Kai Xiang, Fu-Min Zhang, Shao-Hua Wang and Yong-Qiang Tu*. Chem. Commun., 2013, 49, 1648. 3. Palladium-Catalyzed Cascade Process To Construct 1,2,5-Trisubstituted Pyrroles. Yong-Qiang, Zhang; Dao-Yong, Zhu; Bao-Sheng, Li; Yong-Qiang, Tu*; Yong, Lu; Sho-Hua, Wang. J. Org. Chem., 2012, 77, 4167. 2. Total Synthesis of Malyngamides K, L, and 5′′-epi-C and Absolute Configuration of Malyngamide L. Jun-Tao, Zhang; Xian-Liang, Qi; Jie, Chen; Bao-Sheng, Li; You-Bai, Zhou; Xiao-Ping, Cao*. J. Org. Chem., 2011, 76, 3946. 1. Regiodivergent Annulation of AlkynylIndoles To Construct Spiro-pseudoindoxyl and Tetrahydro-β-carbolines. Yong-Qiang, Zhang; Dao-Yong, Zhu; Zhi-Wei, Jiao; Bao-Sheng, Li; Fu-Min, Zhang; Yong-Qiang, Tu*, Org. Lett., 2011, 13, 3458.