Bonizzoni, Marco - The University of Alabama

个人简介

Education: Undergraduate Degree BS, 2003, Università di Pavia (Italy) Education: Doctoral Degree Ph.D., 2007, Università di Pavia (Italy Education: Other Postdoctoral Fellow 2007-2010 The University of Texas at Austin

研究领域

Pattern-based recognition in molecular sensing, molecular assembly through non-covalent interactions, physical organic chemistry of supramolecular systems, fluorescence techniques The primary focus of my research group is supramolecular chemistry. Non-covalent supramolecular interactions are pervasive in Nature. They have also evolved into a powerful and versatile tool in the hands of chemists, for instance in the directed assembly of complex functional structures otherwise unattainable through covalent architecture, or in the design of molecular sensors for analytical purposes. Making molecular sensors from DNA using pattern-based recognition: We intend to use DNA strands immobilized on a solid support as molecular recognition motifs in connection with fluorescence signaling and pattern recognition methods. In fact, an array of non-selective receptors responds to analytes through a signal pattern, whose ìshapeî (intensity vs. position) is typical of the species that generated it. Data treatment through chemometric pattern recognition techniques such as principal component analysis (PCA), linear discriminant analysis (LDA) or artificial neural networks (ANN) will allow us to classify these patterns and thus construct specific sensing systems. Concurrently, we will carry out in-depth physicochemical characterization of the modes of interaction between dyes and DNA through a range of fluorescence techniques: an improved understanding of the nature of these interactions at the fundamental level will allow us to further fine-tune our sensing systems. Fluorescent liposomes as water-dispersed nanoreactors: Liposomes can be used as water-compatible nanoreactors for confinement of solutions at the nanoscale. We are interested in constructing liposome-based reactor vessels and reagent delivery systems equipped with traceable fluorescent labeling as a general-purpose method for diversity-oriented synthesis in aqueous solution. Embedding of fluorescent labels in the liposome membranes will allow tracking of each reactorís contents, thus greatly simplifying library screening and deconvolution compared to current methods. Fluorescently tagged liposome-based libraries also lend themselves to further automation using methods drawn from the biologistís toolbox.

近期论文

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Yuanli Liu, Marco Bonizzoni. A supramolecular sensing array for qualitative and quantitative analysis of organophosphates in water. J. Am. Chem. Soc., 2014, 136 (40), 14223–14229. » Ashley M. Jolly, Marco Bonizzoni. Intermolecular forces driving encapsulation of small molecules by PAMAM dendrimers in water. Macromolecules, 2014, 47 (18), 6281-6288. » Ashley M. Jolly, Marco Bonizzoni. PAMAM dendrimers as supramolecular hosts through noncovalent interactions. Supramol. Chem., 2014. DOI: 10.1080/10610278.2014.915971. » Alie M. Mallet, Yuanli Liu, Marco Bonizzoni. An off-the-shelf sensing system for physiologically relevant phosphates. Chem. Commun., 2014, 50 (39), 5003 - 5006. » Yaolin Xu, Jennifer Sherwood, Ying Qin, Dorothy Crowley, Marco Bonizzoni, Yuping Bao. The role of protein characteristics in the formation and fluorescence of Au nanoclusters. Nanoscale, 2014, 6, 1515-24. » Young Mo Sung, Monica Vasiliu, David A. Dixon, Marco Bonizzoni, Dongho Kim, Thomas P. Vaid. Electronic structure and photophysics of (C=C)tetra-p-tolylporphyrin2+. Photochem. Photobiol. Sci., 2013, 12, 1774-9. » S. Reid Long, Marco Bonizzoni, Brenton M. Ray, Eric V. Anslyn. Differentiation of functional groups and biologically relevant anions using AT-PAMAM dendrimers. Supramol. Chem., 2013, 25, 641-9. » Marco Bonizzoni, S. Reid Long, Chance Rainwater, Eric V. Anslyn. PAMAM Dendrimer-Induced Aggregation of 5(6)-Carboxyfluorescein. J. Org. Chem., 2012, 77, 1258-66. » Tianzhi Zhang, Nicola Y. Edwards, Marco Bonizzoni, Eric V. Anslyn. The Use of Differential Receptors to Pattern Peptide Phosphorylation. J. Am. Chem. Soc., 2009, 131, 11976-84. » Marco Bonizzoni, Eric V. Anslyn. Combinatorial Methods for Chemical and Biological Sensors edited by Radislav A. Potyrailo and Vladimir M. Mirsky. J. Am. Chem. Soc., 2009, 131, 14597-8. » Massimo Boiocchi, Marco Bonizzoni, Alberto Moletti, Dario Pasini, Angelo Taglietti. Linear recognition of dicarboxylates by ditopic macrocyclic complexes. New J. Chem., 2007, 31, 352-6. » Michela Allevi, Marco Bonizzoni, Luigi Fabbrizzi. Homo- and hetero-dinuclear anion complexes. Chem. - Eur. J., 2007, 13, 3787-95. » Marco Bonizzoni, Luigi Fabbrizzi, Angelo Taglietti, Federico Tiengo. (Benzylideneamino)thioureas - chromogenic interactions with anions and N-H deprotonation. Eur. J. Org. Chem., 2006, 3567-74. » Valeria Amendola, Marco Bonizzoni, David Esteban-Gomez, Luigi Fabbrizzi, Maurizio Licchelli, Felix Sancenon, Angelo Taglietti. Some guidelines for the design of anion receptors. Coord. Chem. Rev., 2006, 250, 1451-70. » Marco Bonizzoni, Luigi Fabbrizzi, Giulio Piovani, Angelo Taglietti. Fluorescent detection of glutamate with a dicopper(II) polyamine cage. Tetrahedron, 2004, 60, 11159-62. » Massimo Boiocchi, Marco Bonizzoni, Luigi Fabbrizzi, Giulio Piovani, Angelo Taglietti. A dimetallic cage with a long ellipsoidal cavity for the fluorescent detection of dicarboxylate anions in water. Angew. Chem., Int. Ed., 2004, 43, 3847-52. » Massimo Boiocchi, Marco Bonizzoni, Luigi Fabbrizzi, Francesco Foti, Maurizio Licchelli, Angelo Taglietti, Michele Zema. The influence of the boat-to-chair conversion on the demetalation of the nickel(II) complex of an open-chain tetramine containing a piperazine fragment. Dalton Trans., 2004, 653-8. » Massimo Boiocchi, Marco Bonizzoni, Luigi Fabbrizzi, Francesco Foti, Maurizio Licchelli, Antonio Poggi, Angelo Taglietti, Michele Zema. Does a reinforced kinetic macrocyclic effect exist? The demetalation in strong acid of copper(II) complexes with open and cyclic tetramines containing a piperazine fragment. Chem. - Eur. J., 2004, 10, 3209-16. » Valeria Amendola, Marco Bonizzoni, Luigi Fabbrizzi. Ion translocation within multisite receptors. In Ben L. Feringa (ed.), Molecular Switches - 2nd edition, Wiley, 2011. » Angelo Taglietti, Marco Bonizzoni. Receptors for biological anions. In J.W. Atwood, J.L. Steed (eds.), Encyclopaedia of Supramolecular Chemistry, Taylor & Francis, 2005. »