魏闻 - 重庆大学 - 生命科学学院

个人简介

个人简介 2017/09至今，重庆大学，副研究员 2016/01-2017/08，重庆大学，讲师 2014/07–2015/12，天津医科大学，讲师 2008/09–2014/06，电子科技大学，博士

研究领域

主要研究方向为进化生物学和生物信息学 I. 基于大肠杆菌的实验室进化研究进化机制。采用实验室进化方法，以大肠杆菌这种模式生物研究生物的进化过程，目前主要关注（1）基因突变和基因丢失对适应度的影响（2）生物网络进化的分子机制及驱动力。 II. 理论进化基因组研究。基于进化理论，比较基因组学及系统生物学方法等，通过挖掘公有数据库数据研究（1）新基因的起源和进化（2）适应性进化（3）协同进化（4）蛋白质进化率差异成因等相关遗传学和进化生物学问题

近期论文

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10. Du MZ, Zhang CJ, Wang H, Liu S, Wei W*, Guo FB*(2018) The GC content as a main factor shaping the amino acid usage during bacterial evolution process. Front Microbiol. 9:2948. 9. Wei W, Xiong L, Ye YN, Du MZ, Gao YZ, Zhang KY, Jin YT, Yang Z, Wong PC, Lau SKP, Kan B, Zhu J, Woo PCY*, Guo FB* (2018) Mutation landscape of base substitutions, duplications, and deletions in the representative current cholera pandemic strain. Genome Biol Evol. 10(8):2072-2085. 8. Du MZ, Liu S, Zeng Z, Alemayehu LA, Wei W*, Guo FB*(2018) Amino acid compositions contribute to the proteins' evolution under the influence of their abundances and genomic GC content. Sci Rep. 8(1):7382. 7. Li YM, Zhuang H, Zhang X, Li Y, Liu Y, Yi X, Qin G, Wei W*, Chen R* (2018) Multiomics integration reveals the landscape of prometastasis metabolism in hepatocellular carcinoma. Mol Cell Proteomics.17(4): 607-618. (Cover Story) 6. Wei W, Gao F, Du MZ , Hua HL, Wang J, Guo FB* (2017) Zisland Explorer: detect genomic islands by combining homogeneity and heterogeneity properties. Brief Bioinform. 18 (3) :357-366. (Impact Factor: 9.617) 5. Wei W, Jin YT, Du MZ, Wang J, Rao N, Guo FB* (2016) Genomic complexity places less restrictions on the evolution of young coexpression networks than protein - protein interactions. Genome Biol Evol. 8(8):2624-31. 4. Wei W, Ning LW, Ye YN, Li SJ, Zhou HQ, Huang J, Guo FB* (2014) SMAL: A resource of spontaneous mutation accumulation lines. Mol Biol Evol. 31(5): 1302-1308. (Impact Factor: 10.353) 3. Wei W, Ye YN, Luo S, Deng YY, Lin D, Guo FB* (2014) IFIM: a database of integrated fitness information for microbial genes. Database. 2014: bau052. 2. Wei W, Zhang T, Lin D, Yang ZJ, Guo FB*. (2013) Transcriptional abundance is not the single force driving the evolution of bacterial proteins. BMC Evol Biol. 13: 162. 1. Wei W, Ning LW, Ye YN, Guo FB*. (2013) Geptop: a gene essentiality prediction tool for sequenced bacterial genomes based on orthology and phylogeny. PLoS One. 8(8): e72343.