Pu, Kanyi - Nanyang Technological University - School of Chemical and Biomedical Engineering

个人简介

Prof. Pu is a highly cited researcher listed by Clarivate Analytics, Fellow of the Royal Society of Chemistry (FRSC), and the associate editor for ACS Applied Polymer Materials, Biomaterials Research, and Smart Molecules. With a h-index of 110 (Nov 2023), his work has been highlighted by many world-renown scientific journals such as Nature Biotechnology, Nature Methods, Nature Review Nephrology, Nature Materials, and Cell Express. Assistant Dean For Research, College of Engineering School of Chemical & Biomedical Engineering School of Physics and Mathematical Science Lee Kong Chian School of Medicine Nanyang Technological University 2011-2015: Postdoc, Stanford University 2007-2011: PhD, National University of Singapore 2004-2007: MS, Fudan University 2000-2004: BSc, East China University of Sci & Tech Awards and Honors: 2023 Highly Cited Researcher by Web of Science (Chemistry; Materials Science) 2022 Singapore NRF Investigatorship Award 2022 Highly Cited Researcher by Web of Science (Chemistry; Materials Science) 2021 Highly Cited Researcher by Web of Science (Materials Science) 2020 Highly Cited Researcher by Web of Science (Materials Science) 2020 Elected as Fellow of the Royal Society of Chemistry (FRSC) 2020 Biomaterials Science Lectureship Award, Royal Society of Chemistry 2019 Highly Cited Researcher by Web of Science (Materials Science) 2019 Nanyang Education Award 2019 Distinguished Lectureship Award from the Chemical Society of Japan 2018 Wiley Award for Contribution in Bioscience 2018 Young Innovator Award in Nanobiotechnology by Nano Research 2013 Travel award for young investigators, World Molecular Imaging Congress (WMIC) 2013, Savannah, Georgia, USA

研究领域

The board research objective in my group is to develop multifunctional platform technologies for understanding,detection and treatment of life-threatening diseases. Toward this goal, we will take an interdisciplinary approach that brings together organic chemistry, nanotechnology and molecular biology to synthesize functional polymers,polish their optoelectronic and biochemical properties, and shape them into smart and biocompatible nanoagents for advanced molecular imaging and amplified therapy. There are three major interests of our research. Molecular Imaging Detection and monitoring of pathological processes in disease microenvironment at the molecular level for prognosis, diagnosis and therapeutic outcome assessment. Development of noninvasive high-throughput technologies drug screening with a focus on real-time in vivo imaging of drug metabolism and evolution of drug-induced toxicity. Nanotechnology Development of organic semiconducting nanomaterials with state-of-art imaging modalities such as photoacoustic imaging, near-infrared fluorescence imaging and bioluminescence imaging to improve imaging penetration depth and spatial resolution. Probe Design Design and synthesis of activatable imaging probes to uncover how reactive radical species modulate tumor metabolism, promote metastasis and angiogenesis, and foster drug resistance phenotypes.

近期论文

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Jingsheng Huang, Lichao Su, Cheng Xu, Xiaoguang Ge, Ruiping Zhang, Jibin Song, Kanyi Pu. Molecular radio afterglow probes for cancer radiodynamic theranostics. Nature Materials, 2023, 22, 1421–1429. DOI: 10.1038/s41563-023-01659-1. Jaewon Kim, Sungkyu Lee, Yuri Kim, Minhyeok Choi, Injun Lee, Eunji Kim, Chan Gyu Yoon, Kanyi Pu, Heemin Kang, Jong Seung Kim. In situ self-assembly for cancer therapy and imaging. Nature Reviews Materials, 2023, 8, 710–725. DOI: 10.1038/s41578-023-00589-3. Shasha He, Penghui Cheng, Kanyi Pu. Activatable near-infrared probes for the detection of specific populations of tumour-infiltrating leukocytes in vivo and in urine. Nature Biomedical Engineering, 2023, 7, 281–297. DOI: 10.1038/s41551-023-01009-1. Cheng Xu, Jingsheng Huang, Yuyan Jiang, Shasha He, Chi Zhang, Kanyi Pu. Nanoparticles with ultrasound-induced afterglow luminescence for tumour-specific theranostics. Nature Biomedical Engineering, 2023, 7, 298–312. DOI: 10.1038/s41551-022-00978-z. Jiayan Wu, Kanyi Pu. Leveraging semiconducting polymer nanoparticles for combination cancer immunotherapy. Advanced Materials, 2023, 35, 2308924. [Hall of Fame] Chongzhao Ran, Kanyi Pu. Molecularly produced light and its biomedical applications. Angewandte Chemie International Edition, e202314468. Cheng Xu, Jie Yu, Xiaoyu Ning, Mengke Xu, Shasha He, Jiayan Wu, Kanyi Pu. Semiconducting polymer nanospherical nucleic acid probe for transcriptomic imaging of cancer chemo‐immunotherapy. Advanced Materials, 2023, 35, 2306739. Shasha He, Jie Yu, Mengke Xu, Chi Zhang, Cheng Xu, Penghui Cheng, Kanyi Pu. Semiconducting iron‐chelated nano‐immunomodulator for specific and sensitized sono‐metallo‐immunotherapy of cancer. Angewandte Chemie International Edition, 2023, 62, e202310178. Mengke Xu, Jie Yu, Chi Zhang, Cheng Xu, Xin Wei, Kanyi Pu. Sonodynamic cytokine nanocomplexes with specific stimulation towards effector T cell for combination cancer immunotherapy. Angewandte Chemie International Edition, 2023, 62, e202308362. Xinzhu Wang, Kanyi Pu. Molecular substrates for the construction of afterglow imaging probes in disease diagnosis and treatment. Chemical Society Reviews, 2023, 52, 4549-4566. Penghui Cheng, Rending Wang, Shasha He, Pengpeng Yan, Hongfeng Huang, Jianghua Chen, Jia Shen, Kanyi Pu. Artificial urinary biomarkers for early diagnosis of acute renal allograft rejection. Angewandte Chemie International Edition, 2023, 62, e202306539. Jie Yu, Shasha He, Chi Zhang, Cheng Xu, Jingsheng Huang, Mengke Xu, Kanyi Pu. Polymeric STING pro-agonists for tumor-specific sonodynamic immunotherapy. Angewandte Chemie International Edition, 2023, 62, e202307272. Chi Zhang, Kanyi Pu. Organic sonodynamic materials for combination cancer immunotherapy. Advanced Materials, 2023, 35, 202303059. Jingchao Li, Ningyue Yu, Dong Cui, Jiaguo Huang, Yu Luo, Kanyi Pu. Activatable semiconducting polymer pro-nanomodulators for deep-tissue sono-immunotherapy of orthotopic pancreatic cancer. Angewandte Chemie International Edition, 2023, 62, 202305200. Mengke Xu, Chi Zhang, Shasha He, Cheng Xu, Xin Wei, Kanyi Pu. Activatable immunoprotease nanorestimulator for second near-infrared photothermal immunotherapy of cancer. ACS Nano, 2023, 17, 8183–8194. Xiang Wu, Fan Yang, Sa Cai, Kanyi Pu, Guosong Hong. Nanotransducer-enabled deep-brain neuromodulation with NIR-II light. ACS Nano, 2023, 17, 7941–7952. Penghui Cheng, Shasha He, Chi Zhang, Jing Liu, Kanyi Pu. A tandem-locked fluorescent NETosis reporter for the prognosis assessment of cancer immunotherapy. Angewandte Chemie International Edition, 2023, 62, e202301625. Cheng Xu, Shasha He, Xin Wei, Jingsheng Huang, Mengke Xu, Kanyi Pu. Activatable sonoafterglow nanoprobes for T cell imaging. Advanced Materials, 2023, 35, 2211651. Jingsheng Huang, Chi Zhang, Xinzhu Wang, Xin Wei, Kanyi Pu. Near-infrared photodynamic chemiluminescent probes for cancer therapy and metastasis detection. Angewandte Chemie International Edition, 2023, 62, e202303982. Chi Zhang, Mengke Xu, Ziling Zeng, Xin Wei, Shasha He, Jingsheng Huang, Kanyi Pu. Polymeric extracellular matrix nanoremodeler for activatable cancer photo-immunotherapy. Angewandte Chemie International Edition, 2023, 62, e202217339. Xin Wei, Jingsheng Huang, Chi Zhang, Cheng Xu, Kanyi Pu, Yan Zhang. Highly bright near‐infrared chemiluminescent probes for cancer imaging and laparotomy. Angewandte Chemie International Edition, 2023, 62, e202213791. Jia Miao, Minqian Miao, Yue Jiang, Min Zhao, Prof. Qing Li, Yuan Zhang, Yi An, Kanyi Pu, Qingqing Miao. Activatable NIR‐II fluorescent reporter for in vivo imaging of amyloid‐β plaques. Angewandte Chemie International Edition, 2023, 62,e202216351. Xinzhu Wang, Shasha He, Penghui Cheng, Kanyi Pu. A dual‐locked tandem fluorescent probe for imaging of pyroptosis in cancer chemo‐immunotherapy. Advanced Materials, 2023, 35, 2206510. Chi Zhang, Mengke Xu, Shasha He, Jingsheng Huang, Cheng Xu, Kanyi Pu. Checkpoint Nano-PROTACs for activatable cancer photo-immunotherapy. Advanced Materials, 2023, 35, 2208553. Jiaguo Huang, Xiaona Chen, Yuyan Jiang, Chi Zhang, Shasha He, Hangxiang Wang, Kanyi Pu. Renal clearable polyfluorophore nanosensors for early diagnosis of cancer and allograft rejection. Nature Materials, 2022, 21, 598-607. Xiang Wu, Yuyan Jiang, Nicholas J. Rommelfanger, Fan Yang, Qi Zhou, Rongkang Yin, Junlang Liu, Sa Cai, Wei Ren, Andrew Shin, Kyrstyn S. Ong, Kanyi Pu, Guosong Hong. Tether-free photothermal deep-brain stimulation in freely behaving mice via wide-field illumination in the near-infrared-II window. Nature Biomedical Engineering, 2022, 6, 754-770. Chi Zhang, Jingsheng Huang, Ziling Zeng, Shasha He, Penghui Cheng, Jingchao Li, Kanyi Pu. Catalytical nano-immunocomplexes for remote-controlled sono-metabolic checkpoint trimodal cancer therapy. Nature Communications, 2022, 13, 3468. Jingchao Li, Yu Luo, Ziling Zeng, Dong Cui, Jiaguo Huang, Chenjie Xu, Liping Li, Kanyi Pu, Ruiping Zhang. Precision cancer sono-immunotherapy using deep-tissue activatable semiconducting polymer immunomodulatory nanoparticles. Nature Communications, 2022, 13, 4032. Xianghan Zhang, Jingkai Gao, Yingdi Tang, Jie Yu, Si Si Liew, Chaoqiang Qiao, Yutian Cao, Guohuan Liu, Hongyu Fan, Yuqiong Xia, Kanyi Pu, Jie Tian, Zhongliang Wang. Bioorthogonal activatable cyanine dye with torsion-induced disaggregation for in vivo tumor imaging. Nature Communications, 2022, 13, 3513. Mingwang Yang, Ziling Zeng, Jacky W. Y. Lam, Jiangli Fan, Kanyi Pu, Ben Zhong Tang. State-of-the-art self-luminescence: a win–win situation. Chemical Society Reviews, 2022, 51,8815-8831. Ziling Zeng, Chi Zhang, Shasha He, Jingchao Li, Kanyi Pu. Activatable cancer sono-immunotherapy using semiconducting polymer nanobodies. Advanced Materials, 2022, 34, 2203246. Jingsheng Huang, Penghui Cheng, Cheng Xu, Si Si Liew, Shasha He, Yan Zhang, Kanyi Pu. Chemiluminescent probes with long-lasting high brightness for in vivo imaging of neutrophils. Angewandte Chemie International Edition, 2022, 61, e202203235. Xin Wei, Chi Zhang, Shasha He, Jiaguo Huang, Jingsheng Huang, Si Si Liew, Ziling Zeng, Kanyi Pu. A dual-locked activatable phototheranostic probe for biomarkers regulated photodynamic and photothermal cancer therapy. Angewandte Chemie International Edition, 2022, 61, e202202966. Jiaguo Huang, Shiyun Xian, Yi Liu, Xiaona Chen, Kanyi Pu, Hangxiang Wang. Renal clearable activatable polymeric nanoprobe for early detection of hepatic ischemia-reperfusion injury. Advanced Materials, 2022, 34, 2201357. Yan Zhang, Shasha He, Cheng Xu, Yue Jiang, Qingqing Miao, Kanyi Pu. An activatable polymeric nanoprobe for fluorescence and photoacoustic imaging of tumor-associated neutrophils in cancer immunotherapy. Angewandte Chemie International Edition, 2022, 61, e202203184. Seyoung Koo, Min-Goo Lee, Amit Sharma, Mingle Li, Xingcai Zhang, Kanyi Pu, Sung-Gil Chi, Jong Seung Kim. Harnessing GLUT1 targeted pro-oxidant ascorbate for synergistic phototherapeutics. Angewandte Chemie International Edition, 2022, 61, e202110832. Haidong Li, Heejeong Kim, Feng Xu, Jingjing Han, Qichao Yao, Jingyun Wang, Kanyi Pu, Xiaojun Peng, Juyoung Yoon. Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook. Chemical Society Reviews, 2022, 51, 1795-1835. Yan Zhang, Guopeng Zhang, Ziling Zeng, Kanyi Pu. Activatable molecular probes for fluorescence-guided surgery, endoscopy and tissue biopsy. Chemical Society Reviews, 2022, 51, 566-593. Shasha He, Jing Liu, Chi Zhang, Jun Wang, Kanyi Pu. Semiconducting polymer nano-regulators with cascading activation for photodynamic cancer Immunotherapy. Angewandte Chemie International Edition, 2022, 61, e202116669. Chi Zhang, Shasha He, Ziling Zeng, Penghui Cheng, Kanyi Pu. Smart Nano-PROTACs reprogram tumor microenvironment for activatable photo-metabolic cancer immunotherapy. Angewandte Chemie International Edition, 2022, 61, e202114957. Jing Liu, Shasha He, Yingli Luo, Yue Zhang, Xiaojiao Du, Cheng Xu, Kanyi Pu, Jun Wang. Tumor-microenvironment activatable polymer nano-immunomodulator for precision cancer photoimmunotherapy. Advanced Materials, 2022, 34, 2106654. Yijing Zhang, Jingchao Li, Kanyi Pu. Recent advances in dual-and multi-responsive nanomedicines for precision cancer therapy. Biomaterials, 2022, 291, 121906.