个人简介

B.S. Virginia Tech, 1999 Ph.D. University of Kansas, 2005 Postdoc California Institute of Technology, 2004–2007

研究领域

Organic, Medicinal and Bioorganic Chemistry

Organic Synthesis Asymmetric Catalysis Medicinal Chemistry/Drug Discovery Bioorganic Chemistry Mechanistic Studies Computational Chemistry Research in our group is primarily focused on organic synthesis, broadly defined. Specific efforts have been inspired by complex, biologically relevant natural products and a desire to develop efficient synthetic routes for their construction. We are also interested in the design and construction of natural product analogs with improved biological properties. Along the way, group members will be involved in various aspects of methodology development, catalyst design, and mechanism study. A few specific research areas of current interest are: New Methods and Strategies for Natural Product Synthesis Examples of current natural product targets of interest are the hasubanan alkaloids, briarane diterpenoids, azaphilone lactones, and the structurally related compounds biselyngbyaside and biselyngbyolide A. Many of these targets build on our interest in studying cyclohexadienone reactivity. Design of Asymmetric Hypervalent Iodine Catalysts and Study of Reactivity Our group is actively pursuing the design of chiral aryl iodide catalysts for asymmetric oxidation reactions. In support of these efforts we are using experimental and computational methods to study various mechanistic details of iodine(III)-mediated oxidative dearomatization. Design of Novel Electrophiles as Biological Probes & Medicinal Agents Our group has already identified new small molecules that can serve as electrophilic inhibitors of the NF-kB signaling pathway. Building off this success we are working to identify other novel electrophiles for use as medicinal agents and probes for biological pathways.

近期论文

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Moon, N. G.; Harned, A. M. A Concise Synthetic Route to the Stereotetrad Core of the Briarane Diterpenoids. Org. Lett. 2015, DOI: 10.1021/acs.orglett.5b00816. (abstract) Harned, A. M. α-Alkylation of a norbornene-derived tricyclic ketone: are steric factors really in control? Chem. Commun. 2015, 51, 2076–2079. (abstract) Kalstabakken, K. A.; Harned, A. M. Asymmetric transformations of achiral 2,5-cyclohexadienones. Tetrahedron 2014,70, 9571–9585. (Invited report article) (abstract) Harned, A. M. Asymmetric oxidative dearomatizations promoted by hypervalent iodine(III) reagents: an opportunity for rational catalyst design? Tetrahedron Lett. 2014, 55, 4681–4689. (Invited digest article) (abstract) Volp, K. A.; Harned, A. M. Origin of Stereoselectivity of the Alkylation of Cyclohexadienone-Derived Bicyclic Malonates. J. Org. Chem. 2013, 78, 7554–7564. (abstract) Tello-Aburto, R.; Kalstabakken, K. A.; Harned, A. M. Ligand and Substrate Effects During Pd-Catalyzed Cyclizations of Alkyne-Tethered Cyclohexadienones. Org. Biomol. Chem. 2013, 11, 5596–5604. (abstract) Kalstabakken, K. A.; Harned, A. M. Spectral Database for Instructors: A Living, Online NMR FID Database. J. Chem. Ed. 2013, 90, 941–943. (abstract) Moon, N. G.; Harned, A. M. Iodine(III)-promoted synthesis of oxazolines from N-allylamides. Tetrahedron Lett. 2013, 54, 2960–2963. (abstract) Volp, K. A.; Harned, A. M. Chiral Aryl Iodide Catalysts for the Enantioselective Synthesis of para-Quinols. Chem. Commun. 2013, 49, 3001–3003. (abstract) Hexum, J. K.; Tello-Aburto, R.; Struntz, N. B.; Harned, A. M.; Harki, D. A. Bicyclic Cyclohexenones as Inhibitors of NF-κB Signaling. ACS Med. Chem. Lett. 2012, 3, 459–464. (abstract) Harned, A. M.; Volp, K. A. The sorbicillinoid family of natural products: Isolation, biosynthesis, and synthetic studies.Nat. Prod. Rep. 2011, 28, 1790–1810. (abstract) Tello-Aburto, R.; Kalstabakken, K. A.; Volp, K. A.; Harned, A. M. Regioselective and Stereoselective Cyclization of Cyclohexadienones Tethered to Active Methylene Groups. Org. Biomol. Chem. 2011, 9, 7849–7859. (abstract)(Featured in the top 10% of the most highly cited articles published in the Impact Factor window for 2011-2012) Volp, K. A.; Johnson, D. M.; Harned, A. M. A Concise Synthetic Approach to the Sorbicillactones: Total Synthesis of Sobicillactone A and 9-epi-Sorbicillactone A. Org. Lett. 2011, 13, 4486–4489. (abstract) Lang, P. T.; Harned, A. M.; Wissinger, J. E. Oxidation of Borneol to Camphor using Oxone and Catalytic Sodium Chloride: A Green Experiment for the Undergraduate Organic Chemistry Laboratory. J. Chem. Ed. 2011, 88, 652–656. (abstract) Rout, L.; Harned, A. M. Allene Carboxylates as Dipolarophiles in Rh-Catalyzed Carbonyl Ylide Cycloadditions. Chem. Eur. J. 2009, 15, 12926–12928. (abstract) Tello-Aburto, R.; Harned, A. M. Palladium-Catalyzed Reactions of Cyclohexadienones: Regioselective Cyclizations Triggered by Alkyne Acetoxylation. Org. Lett. 2009, 11, 3998–4000. (abstract)