Pikal, Michael - University of Connecticut

个人简介

B.A. St. John’s University, Minnesota, Chemistry Ph.D. Iowa State University, Physical Chemistry

研究领域

Lyophilization of proteins and other pharmaceuticals – process, formulation and stability Solid state chemistry of proteins Dynamics in the glassy state and pharmaceutical stability

近期论文

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Luthra, S.A., Shalaev, E.Y., Medec, A., Hong, J., Pikal, M.J. (2012) Chemical stability of amorphous materials: Specific and general media effects in the role of water in the degradation of freeze-dried zoniporide, J. Pharm. Sci. 101(9), 3110-3123. Padilla, A.M., Pikal, M.J. (2011) The study of phase separation in amorphous freeze-dried systems, part 2: Investigation of Raman mapping as a tool for studying amorphous phase separation in freeze dried protein formulations, J. Pharm. Sci.100(4), 1467-1474. Patel, S.M., Pikal, M.J. (2011) Emerging Freeze-Drying Process Development and Scale-up Issues, AAPS PharmSciTech 12(1), 372-378. Murdande, S.B., Pikal, M.J., Shanker, R.M., Bogner, R.H. (2010) Solubility advantage of amorphous pharmaceuticals: I. A thermodynamic analysis, J. Pharm. Sci. 99(3), 1254-1264. Wang, B., Cicerone, M.T., Pikal, M.J. (2010) The impact of thermal treatment on the stability of freeze dried amorphous pharmaceuticals: II. Aggregation in an IgG1 Fusion Protein, J. Pharm. Sci. 99, 683-700. Abdul-Fattah, A.M., Kalonia, D.S., Pikal, M.J. (2007) The challenge of drying method selection for protein pharmaceuticals: product quality implications, J. Pharm. Sci. 96(8), 1886-1916.