Wright, Dennis - University of Connecticut

个人简介

B.S. West Liberty State College, Chemistry Ph.D. Ohio University, Chemistry Postdoctoral Training: Stanford University, Chemistry

研究领域

Development of small-molecule therapeutics based on complex natural products Therapeutic development for infectious disease, cancer and neurodegenerative disorders

近期论文

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VanHeyst, M.D., Oblak, E.Z., Wright, D.L. (2013) Stereodivergent Resolution of Oxabicyclic Ketones: Preparation of Key Intermediates for Platensimycin and Other Natural Products, J. Org. Chem. 78, 10555-9. Ononye, S.N., VanHeyst, M.D., Oblak, E.Z., Ammar, M., Anderson, A.C., Wright, D.L. (2013) Tropolones as Lead-Like Natural Products: The Development of Potent Histone Deacetylase Inhibitors, ACS Med. Chem. Lett. 4, 757-61. Cooper, H.D., Wright, D.L. (2013) The Tandem Ring Opening/Ring Closing Metathesis Route to Oxaspirocycles: An Approach to Phelligridin G, Molecules 18, 2438-2448. Paulsen, J.L., Viswanathan, K., Wright, D.L., Anderson, A.C. (2013) Structural Analysis of the Active Sites of Dihydrofolate Reductase From Two Species of Candida Uncovers Ligand-induced Conformational Changes Shared Among Species, Bioorg. Med. Chem. Lett. 23, 1279-1284. Viswanathan, K., Frey, K.M., Scocchera, E.W., Martin, B.D., Dwain, P.W., Alverson, J.B., Priestley, N.D., Anderson, A.C., Wright, D.L. (2012) Toward New Therapeutics for Skin and Soft Tissue Infections: Propargyl-Linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenes, PLoS ONE 7(2), e29434. Oblak, E.Z., Wright, D.L. (2011) Highly Substituted Oxabicyclic Derivatives from Furan: Synthesis of (±)-Platensimycin, Org. Lett. 13, 2263-5.