个人简介
B.S. University of Notre Dame, Biology
M.S. Colorado State University, Biochemistry & Molecular Biology
Ph.D. University of Iowa, Molecular & Cellular Biology
Postdoctoral Training: University of Wisconsin – Madison
研究领域
Signaling mechanisms of integrin regulatory proteins
Design and characterization of isoprenoid biosynthesis inhibitors
Discovery of novel therapeutics for hematological malignancies
His areas of research include estuarine water quality management and estuarine plant-water quality interactions.
近期论文
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Wiemer, A.J., Wernimont, S.A., Cung, T.D., Bennin, D.A., Beggs, H.E., Huttenlocher, A. (2013) The focal adhesion kinase/Pyk2 inhibitor PF-562,271 impairs primary CD4+ T cell activation, Biochem Pharmacol. 86(6), 770-81.
Wiemer A.J., Wernimont, S.A., Huttenlocher A. (2012) Live imaging of LFA-1 dependent T cell motility and stop signals, Methods Mol. Biol. 757, 191-204.
Wernimont, S.A., Wiemer, A.J., Monkley, S., Critchley, D., Ludwig, T.E., Huttenlocher, A. (2011) Contact-dependent T cell activation and T cell stopping require talin1, J. Immunol. 187(12), 6256-67.
Wiemer, A.J., Hegde, S., Gumperz, J., Huttenlocher, A. (2011) A live imaging cell motility screen identifies prostaglandin e2 as a T cell stop signal antagonist, J. Immunol. 187(7), 3663-70.
Wiemer, A.J., Hohl, R.J., Wiemer D.F. (2011) Geranylgeranyl diphosphate synthase: Emerging therapeutic target, Clin. Pharmacol. Ther. 90(6), 804-12.
Dudakovic, A., Wiemer, A.J., Lamb, K.M., Vonnahme, L.A., Dietz, S.A., Hohl, R.J. (2008) Inhibition of geranylgeranyl diphosphate synthase induces apoptosis through multiple mechanisms and displays synergy with other inhibitors of isoprenoid biosynthesis, J. Pharmacol. Exp. Ther. 324(3), 1028-36.