Hadden, M. Kyle - University of Connecticut

个人简介

B.S. Wofford College, Chemistry Ph.D. Medical University of South Carolina, Medicinal Chemistry Postdoctoral Training: University of Kansas, Medicinal Chemistry

研究领域

Organic synthesis of small molecule hedgehog pathway modulators Evaluation of compounds in cell-based assays for treatment of cancer and neurodegenerative disorders High-throughput screening

近期论文

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Hadden, M.K. (2014) Hedgehog pathway agonism: Therapeutic applications and small molecule development, ChemMedChem 9, 27-37. DeBerardinis, A.M., Banerjee, U., Hadden, M.K. (2013) Identification of vitamin-D3-based hedgehog pathway inhibitors that incorporate an aromatic A-ring isostere, ACS Med. Chem. Lett. 4, 590-595. DeBerardinis, A.M., Lemieux, S., Hadden, M.K. (2013) Analogues of the Inhoffen-Lythgoe diol with anti-proliferative activity, Bioorg. Med. Chem. Lett. 23, 5367-5370. Sail, V., Hadden, M.K. (2013) Identification of small molecule Hes1 modulators as potential anti-cancer chemotherapeutics, Chem. Biol. & Drug Design. 81, 334-342. Corman, A., DeBerardinis, A., Hadden, M.K. (2012) Structure-activity relationships for side chain oxysterol agonists of hedgehog signaling, ACS Med. Chem. Lett. 3, 828-833. DeBerardinis, A., Banerjee, U., Miller, M., Lemieux, S., Hadden, M.K. (2012) Probing the structural requirements for vitamin D3 inhibition of hedgehog signaling, Bioorg. Med. Chem. Lett. 22, 4859-4863.