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B.Sc. University of Calcutta Chemistry M.Sc. University of Calcutta Biochemistry Ph.D. Bose Institute, University of Calcutta Biochemist

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A thiol-disulfide oxidoreductase of the Gram-positive pathogen Corynebacterium diphtheriae is essential for viability, pilus assembly, toxin production and virulence. Reardon-Robinson, Melissa E; Osipiuk, Jerzy; Jooya, Neda; Chang, Chungyu; Joachimiak, Andrzej; Das, Asis; Ton-That, Hung Molecular microbiology 2015 Aug; A Disulfide Bond-forming Machine Is Linked to the Sortase-mediated Pilus Assembly Pathway in the Gram-positive Bacterium Actinomyces oris. Reardon-Robinson, Melissa E; Osipiuk, Jerzy; Chang, Chungyu; Wu, Chenggang; Jooya, Neda; Joachimiak, Andrzej; Das, Asis; Ton-That, Hung The Journal of biological chemistry 2015 Jul;290(35):21393-405 Two autonomous structural modules in the fimbrial shaft adhesin FimA mediate Actinomyces interactions with streptococci and host cells during oral biofilm development. Mishra, Arunima; Devarajan, Bharanidharan; Reardon, Melissa E; Dwivedi, Prabhat; Krishnan, Vengadesan; Cisar, John O; Das, Asis; Narayana, Sthanam V L; Ton-That, Hung Molecular microbiology 2011 Sep;81(5):1205-20 Cell surface display of minor pilin adhesins in the form of a simple heterodimeric assembly in Corynebacterium diphtheriae. Chang, Chungyu; Mandlik, Anjali; Das, Asis; Ton-That, Hung Molecular microbiology 2011 Mar;79(5):1236-47 Adhesion by pathogenic corynebacteria. Rogers, Elizabeth A; Das, Asis; Ton-That, Hung Advances in experimental medicine and biology 2011 Jan;71591-103 The Actinomyces oris type 2 fimbrial shaft FimA mediates co-aggregation with oral streptococci, adherence to red blood cells and biofilm development. Mishra, Arunima; Wu, Chenggang; Yang, Jinghua; Cisar, John O; Das, Asis; Ton-That, Hung Molecular microbiology 2010 Jun;77(4):841-54 Acyl enzyme intermediates in sortase-catalyzed pilus morphogenesis in gram-positive bacteria. Guttilla, Irene K; Gaspar, Andrew H; Swierczynski, Arlene; Swaminathan, Anu; Dwivedi, Prabhat; Das, Asis; Ton-That, Hung Journal of bacteriology 2009 Sep;191(18):5603-12 The molecular switch that activates the cell wall anchoring step of pilus assembly in gram-positive bacteria. Mandlik, Anjali; Das, Asis; Ton-That, Hung Proceedings of the National Academy of Sciences of the United States of America 2008 Sep;105(37):14147-52 Housekeeping sortase facilitates the cell wall anchoring of pilus polymers in Corynebacterium diphtheriae. Swaminathan, Anu; Mandlik, Anjali; Swierczynski, Arlene; Gaspar, Andrew; Das, Asis; Ton-That, Hung Molecular microbiology 2007 Nov;66(4):961-74 ADAR editing wobbles the microRNA world. Das, Asis K; Carmichael, Gordon G ACS chemical biology 2007 Apr;2(4):217-20 Corynebacterium diphtheriae employs specific minor pilins to target human pharyngeal epithelial cells. Mandlik, Anjali; Swierczynski, Arlene; Das, Asis; Ton-That, Hung Molecular microbiology 2007 Apr;64(1):111-24 Sortase-catalyzed assembly of distinct heteromeric fimbriae in Actinomyces naeslundii. Mishra, Arunima; Das, Asis; Cisar, John O; Ton-That, Hung Journal of bacteriology 2007 Apr;189(8):3156-65 GreA and GreB proteins revive backtracked RNA polymerase in vivo by promoting transcript trimming. Toulmé, F; Mosrin-Huaman, C; Sparkowski, J; Das, A; Leng, M; Rahmouni, A R The EMBO journal 2000 Dec;19(24):6853-9 The structure of the transcriptional antiterminator NusB from Escherichia coli. Altieri, A S; Mazzulla, M J; Horita, D A; Coats, R H; Wingfield, P T; Das, A; Court, D L; Byrd, R A Nature structural biology 2000 Jun;7(6):470-4 The functional role of basic patch, a structural element of Escherichia coli transcript cleavage factors GreA and GreB. Kulish, D; Lee, J; Lomakin, I; Nowicka, B; Das, A; Darst, S; Normet, K; Borukhov, S The Journal of biological chemistry 2000 Apr;275(17):12789-98 A novel mutation in the KH domain of polynucleotide phosphorylase affects autoregulation and mRNA decay in Escherichia coli. García-Mena, J; Das, A; Sánchez-Trujillo, A; Portier, C; Monta?ez, C Molecular microbiology 1999 Jul;33(2):235-48 Regulation of the elongation-termination decision at intrinsic terminators by antitermination protein N of phage lambda. Rees, W A; Weitzel, S E; Das, A; von Hippel, P H Journal of molecular biology 1997 Nov;273(4):797-813 Complexes of N antitermination protein of phage lambda with specific and nonspecific RNA target sites on the nascent transcript. Van Gilst, M R; Rees, W A; Das, A; von Hippel, P H Biochemistry 1997 Feb;36(6):1514-24 Bacteriophage lambda N protein alone can induce transcription antitermination in vitro. Rees, W A; Weitzel, S E; Yager, T D; Das, A; von Hippel, P H Proceedings of the National Academy of Sciences of the United States of America 1996 Jan;93(1):342-6 Role of Escherichia coli RNA polymerase alpha subunit in modulation of pausing, termination and anti-termination by the transcription elongation factor NusA. Liu, K; Zhang, Y; Severinov, K; Das, A; Hanna, M M The EMBO journal 1996 Jan;15(1):150-61 Components of multiprotein-RNA complex that controls transcription elongation in Escherichia coli phage lambda. Das, A; Pal, M; Mena, J G; Whalen, W; Wolska, K; Crossley, R; Rees, W; von Hippel, P H; Costantino, N; Court, D; Mazzulla, M; Altieri, A S; Byrd, R A; Chattopadhyay, S; DeVito, J; Ghosh, B Methods in enzymology 1996 Jan;274374-402 Immunoprinting: a technique used to study dynamic protein-nucleic acid interactions within transcription elongation complex. Das, A; Barik, S; Ghosh, B; Whalen, W Methods in enzymology 1996 Jan;274363-74 Modulation of pausing, termination and antitermination in E. coli by the transcription elongation factor NusA: Role of RNA polymerase alpha subunit Liu K, Zhang Y, Severinov K, Das A, Hanna M EMBO J 1996 Jan;15(1):150-161 Interaction between the phage HK022 Nun protein and the nut RNA of phage lambda. Chattopadhyay, S; Hung, S C; Stuart, A C; Palmer, A G; Garcia-Mena, J; Das, A; Gottesman, M E Proceedings of the National Academy of Sciences of the United States of America 1995 Dec;92(26):12131-5 Bipartite function of a small RNA hairpin in transcription antitermination in bacteriophage lambda. Chattopadhyay, S; Garcia-Mena, J; DeVito, J; Wolska, K; Das, A Proceedings of the National Academy of Sciences of the United States of America 1995 Apr;92(9):4061-5

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