Cowan, Ann - University of Connecticut - Department of Molecular Biology and Biophysics

个人简介

B.S. Queen’s University Biology M.S. Yale University Biology Ph.D. University of Colorado Molecular, Cellular, and Developmental Biology

研究领域

Khurana, L., Fu, B., Duddupudi, A., Liao, Y.-H., Immadi, S. S., Kendall, D.A. Lu, D. (2017) Pyrimidinyl Biphenylureas: Identification of New Lead Compounds as Allosteric Modulators of the Cannabinoid Receptor CB1. J. Med. Chem., in press. Kendall, D.A. and Yudowski, G.A. (2017) Cannabinoid Receptors in the Central Nervous System: Their Signaling and Roles in Disease. Front. Cell. Neurosci. 10, 294. Doi: 10.3389. Qiao C.-J,. Ali, H.I., Ahn, K.H., Kolluru, S., Kendall, D.A. and Lu, D. (2016) Synthesis and Biological Evaluation of Indole-2-carboxamides Bearing Photoactivatable Functionalities as Novel Allosteric Modulators for the Cannabinoid CB1 Receptor. Eur. J. Med. Chem. 121, 517-529. Delgado-Peraza, F., Ahn, K.H., Nogueras-Ortiz, C., Mungrue, I. Mackie, K.P., Kendall, D.A. and Yudowski, G.A. (2016) Mechanisms of Biased Beta-arrestin Mediated Signaling Downstream from the Cannabinoid 1 Receptor. Mol. Pharmacol. 89, 645-651. Shim, J.-Y., Khurana, L. and Kendall, D.A. (2016) Computational Analysis of the CB1 Carboxyl-terminus in the Receptor-G Protein Complex. Proteins: Struct. Funct. Bioinf. 84, 532-543. Flores-Otero, J., Ahn, K.H., Delgado-Peraza, F., Mackie, K., Kendall, D.A. and Yudowski, G.A. (2014) Ligand-Specific Endocytic Dwell Times Control Functional Selectivity of the Cannabinoid Receptor 1. Nature Communications 5, 1-11.

近期论文

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Stimulation of microtubule-based transport by nucleation of microtubules on pigment granules. Semenova, Irina; Gupta, Dipika; Usui, Takeo; Hayakawa, Ichiro; Cowan, Ann; Rodionov, Vladimir Molecular biology of the cell 2017 Apr; Engineered tug-of-war between kinesin and dynein controls direction of microtubule transport in vivo. Rezaul, Karim; Gupta, Dipika; Semenova, Irina; Ikeda, Kazuho; Kraikivski, Pavel; Yu, Ji; Cowan, Ann; Zaliapin, Ilya; Rodionov, Vladimir Traffic (Copenhagen, Denmark) 2016 Feb; Native serotonin 5-HT2C receptors are expressed as homodimers on the apical surface of choroid plexus epithelial cells. Herrick-Davis, Katharine; Grinde, Ellinor; Lindsley, Tara; Teitler, Milt; Mancia, Filippo; Cowan, Ann; Mazurkiewicz, Joseph E Molecular pharmacology 2015 Jan;87(4):660-73 Analysis of the dynamics of a Bacillus subtilis spore germination protein complex during spore germination and outgrowth. Troiano, Anthony J; Zhang, Jingqiao; Cowan, Ann E; Yu, Ji; Setlow, Peter Journal of bacteriology 2015 Jan;197(2):252-61 Regulation of microtubule-based transport by MAP4. Semenova, Irina; Ikeda, Kazuho; Resaul, Karim; Kraikivski, Pavel; Aguiar, Mike; Gygi, Steven; Zaliapin, Ilya; Cowan, Ann; Rodionov, Vladimir Molecular biology of the cell 2014 Aug;25(20):3119-32 Fluorescence correlation spectroscopy analysis of serotonin, adrenergic, muscarinic, and dopamine receptor dimerization: the oligomer number puzzle. Herrick-Davis, Katharine; Grinde, Ellinor; Cowan, Ann; Mazurkiewicz, Joseph E Molecular pharmacology 2013 Oct;84(4):630-42 Expression level of Bacillus subtilis germinant receptors determines the average rate but not the heterogeneity of spore germination. Zhang, Jing-qiao; Griffiths, Keren K; Cowan, Ann; Setlow, Peter; Yu, Ji Journal of bacteriology 2013 Apr;195(8):1735-40 Novel 3D analysis of Claudin-5 reveals significant endothelial heterogeneity among CNS microvessels. Paul, Debayon; Cowan, Ann E; Ge, Shujun; Pachter, Joel S Microvascular research 2013 Mar;861-10 Oligomer size of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor revealed by fluorescence correlation spectroscopy with photon counting histogram analysis: evidence for homodimers without monomers or tetramers. Herrick-Davis, Katharine; Grinde, Ellinor; Lindsley, Tara; Cowan, Ann; Mazurkiewicz, Joseph E The Journal of biological chemistry 2012 Jul;287(28):23604-14 Spatial modeling of cell signaling networks. Cowan, Ann E; Moraru, Ion I; Schaff, James C; Slepchenko, Boris M; Loew, Leslie M Methods in cell biology 2012 Jan;110195-221 Vacuolar protein sorting protein 13A, TtVPS13A, localizes to the tetrahymena thermophila phagosome membrane and is required for efficient phagocytosis. Samaranayake, Haresha S; Cowan, Ann E; Klobutcher, Lawrence A Eukaryotic cell 2011 Sep;10(9):1207-18 Germination proteins in the inner membrane of dormant Bacillus subtilis spores colocalize in a discrete cluster. Griffiths, Keren K; Zhang, Jingqiao; Cowan, Ann E; Yu, Ji; Setlow, Peter Molecular microbiology 2011 Aug;81(4):1061-77 Dynamics of peptidergic secretory granule transport are regulated by neuronal stimulation. Sobota, Jacqueline A; Mohler, William A; Cowan, Ann E; Eipper, Betty A; Mains, Richard E BMC neuroscience 2010 Jan;1132 Virus-Induced Chaperone-Enriched (VICE) domains function as nuclear protein quality control centers during HSV-1 infection. Livingston, Christine M; Ifrim, Marius F; Cowan, Ann E; Weller, Sandra K PLoS pathogens 2009 Oct;5(10):e1000619 Levels and localization of mechanosensitive channel proteins in Bacillus subtilis. Wahome, Paul G; Cowan, Ann E; Setlow, Barbara; Setlow, Peter Archives of microbiology 2009 May;191(5):403-14 Analysis of dye binding by and membrane potential in spores of Bacillus species. Magge, A; Setlow, B; Cowan, A E; Setlow, P Journal of applied microbiology 2009 Mar;106(3):814-24 Role for Rab3a in oligodendrocyte morphological differentiation. Anitei, Mihaela; Cowan, Ann E; Pfeiffer, Steven E; Bansal, Rashmi Journal of neuroscience research 2009 Feb;87(2):342-52 Using the virtual cell simulation environment for extracting quantitative parameters from live cell fluorescence imaging data Cowan A.E., Ye L., Morgan F.R., Koppel D.E., Slepchenko B.M., Loew L.M., Schaff J. Microscopy and Microanalysis 2009 Jan;15(SUPPL. 2):1522-1523 Cyclic 3',5'-AMP causes ADAM1/ADAM2 to rapidly diffuse within the plasma membrane of guinea pig sperm. Hunnicutt, Gary R; Koppel, Dennis E; Kwitny, Susanna; Cowan, Ann E Biology of reproduction 2008 Nov;79(5):999-1007 Characterization of spores of Bacillus subtilis that lack most coat layers. Ghosh, Sonali; Setlow, Barbara; Wahome, Paul G; Cowan, Ann E; Plomp, Marco; Malkin, Alexander J; Setlow, Peter Journal of bacteriology 2008 Oct;190(20):6741-8 Luteinizing hormone causes MAP kinase-dependent phosphorylation and closure of connexin 43 gap junctions in mouse ovarian follicles: one of two paths to meiotic resumption. Norris, Rachael P; Freudzon, Marina; Mehlmann, Lisa M; Cowan, Ann E; Simon, Alexander M; Paul, David L; Lampe, Paul D; Jaffe, Laurinda A Development (Cambridge, England) 2008 Oct;135(19):3229-38 How moist heat kills spores of Bacillus subtilis. Coleman, William H; Chen, De; Li, Yong-Qing; Cowan, Ann E; Setlow, Peter Journal of bacteriology 2007 Dec;189(23):8458-66 Planar spindle orientation and asymmetric cytokinesis in the mouse small intestine. Fleming, Elizabeth S; Zajac, Mark; Moschenross, Darcy M; Montrose, David C; Rosenberg, Daniel W; Cowan, Ann E; Tirnauer, Jennifer S The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007 Nov;55(11):1173-80 Microtubule motor Ncd induces sliding of microtubules in vivo. Oladipo, Abiola; Cowan, Ann; Rodionov, Vladimir Molecular biology of the cell 2007 Sep;18(9):3601-6 Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system. Takeda, Kotaro; Cowan, Ann; Fong, Guo-Hua Circulation 2007 Aug;116(7):774-81