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Kosciuk T, Price IR, Zhang X, Zhu C, Johnson KN, Zhang S, Halaby SL, Komaniecki GP, Yang M, DeHart CJ, Thomas PM, Kelleher NL, Fromme JC, Lin H. “NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle.” Nat Commun. Feb 26, 2020 Link
Fenwick MK, Su D, Dong M, Lin H, Ealick SE. “Structural Basis of the Substrate Selectivity of Viperin.” Biochemistry. Feb 11, 2020 Link
Greene KS, Lukey MJ, Wang X, Blank B, Druso JE, Lin MJ, Stalnecker CA, Zhang C, Negrón Abril Y, Erickson JW, Wilson KF, Lin H, Weiss RS, Cerione RA. “SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis.” Proc Natl Acad Sci U S A. Dec 16, 2019 Link
Zhang Y, Wang M, Lin H. “A Regulatory Cysteine Residue Mediates Reversible Inactivation of NAD+-Dependent Aldehyde Dehydrogenases to Promote Oxidative Stress Response.” ACS Chem Biol. Dec 16, 2019 Link
Fenwick MK, Dong M, Lin H, Ealick SE. “Crystal structure of Dph2 in complex with elongation factor 2 reveals structural basis for first step of diphthamide biosynthesis.” Biochemistry. Sep 30, 2019 Link
Dong M, Dando EE, Kotliar I, Su X, Dzikovski B, Freed JH, Lin H. “The asymmetric function of Dph1-Dph2 heterodimer in diphthamide biosynthesis.” J Biol Inorg Chem. Aug 28, 2019 Link
Spiegelman NA, Zhang X, Jing H, Cao J, Kotliar IB, Aramsangtienchai P, Wang M, Tong Z, Rosch KM, Lin H. “SIRT2 and Lysine Fatty Acylation Regulate the Activity of RalB and Cell Migration.” ACS Chem Biol. Aug 21, 2019 Link
Hong JY, Price IR, Bai JJ, Lin H. “A Glycoconjugated SIRT2 Inhibitor with Aqueous Solubility Allows Structure-Based Design of SIRT2 Inhibitors.” ACS Chem Biol. Aug 2, 2019 Link
Son SI, Cao J, Zhu CL, Miller SP, Lin H. “Activity-Guided Design of HDAC11-Specific Inhibitors.” ACS Chem Biol. Jul 2, 2019 Link
Li M, Chiang YL, Lyssiotis CA, Teater MR, Hong JY, Shen H, Wang L, Hu J, Jing H, Chen Z, Jain N, Duy C, Mistry SJ, Cerchietti L, Cross JR, Cantley LC, Green MR, Lin H, Melnick AM. “Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis.” Cancer Cell. Jun 10, 2019 Link
Zhang S, Spiegelman NA, Lin H. “Global Profiling of Sirtuin Deacylase Substrates Using a Chemical Proteomic Strategy and Validation by Fluorescent Labeling.” Methods Mol Biol. Jun 4, 2019 Link
Hong JY, Cao J, Lin H. “Fluorogenic Assays for the Defatty-Acylase Activity of Sirtuins.” Methods Mol Biol. Jun 4, 2019 Link
Farooqi AS, Hong JY, Cao J, Lu X, Price IR, Zhao Q, Kosciuk T, Yang M, Bai JJ, Lin H. “Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model.” J Med Chem. Apr 25, 2019 Link
Latifkar A, Ling L, Hingorani A, Johansen E, Clement A, Zhang X, Hartman J, Fischbach C, Lin H, Cerione RA, Antonyak MA. “Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity.” Dev Cell. Apr 1, 2019 Link
Wang H, Zeng X, Mo Y, He B, Lin H, Lin J. “Characterization of the enterobactin-specific antibodies induced by a novel enterobactin conjugate vaccine.” Appl Environ Microbiol. Mar 15, 2019 Link
Kosciuk T, Wang M, Hong JY, Lin H. “Updates on the epigenetic roles of sirtuins.” Curr Opin Chem Biol. March 12, 2019 Link
Cao J, Sun L, Aramsangtienchai P, Spiegelman NA, Zhang X, Huang W, Seto E, Lin H. “HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2.” PNAS. Feb 28, 2019 Link
Spiegelman NA, Hong JY, Hu J, Jing H, Wang M, Price IR, Cao J, Yang M, Zhang X, Lin H. “A Small Molecule SIRT2 Inhibitor that Promotes K-Ras4a Lysine Fatty-acylation.” ChemMedChem. Feb 7, 2019 Link
Wang WW, Angulo-Ibanez M, Lyu J, Kurra Y, Tong Z, Wu B, Zhang L, Sharma V, Zhou J, Lin H, Gao YQ, Li W, Chua KF, Liu WR. “A Click Chemistry Approach Reveals the Chromatin-Dependent Histone H3K36 Deacylase Nature of SIRT7.” J Am Chem Soc. Jan 17, 2019 Link
Zhang Y, Lin Z, Wang M, Lin H. “Selective usage of isozymes for stress response.” ACS Chem Biol. Oct 17, 2018 Link
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