个人简介

Ph.D., University of Texas at Austin, 1991; Postdoctoral Study, Institute of Biological Chemistry, Washington State University

研究领域

Biochemistry

Plant Beneficial-Microbe Interactions Plant Metabolomics Marine Natural-Product Chemistry Research activities focus on: [i] characterizing signaling mechanisms that operate in plant-microbe interactions and [ii] chemically characterize natural products from plant and marine sources with biological activity within a medical context. The lab fosters the training of undergraduate, graduate and post-doctoral researchers. Experimental approaches include techniques in analytical and organic chemistry as well as molecular and microbiology. Research projects that are ongoing are summarized below. Beneficial Bacterial Induce Plant Growth Researchers, in collaboration with Lanzhou University in China study how beneficial soil bacteria induce growth promotion, nutrient uptake and abiotic stress tolerance in plants. Such bacteria form mutually beneficial associations with below-ground roots through a complex exchange of signaling molecules, some of which have been chemically characterized and assayed for biological activity. It has been established that bacterial elicitors activate differential expression of over 600 plant transcripts related to inducible salt- and drought-tolerance as well as iron uptake resulting in greater photosynthetic efficiency. Understanding how bacteria regulate plant processes of growth and development has important implications in increasing agricultural output and improved human nutrition. Plant Metabolomics Researchers, in collaboration with the National Research Centre in Egypt collect and chemically characterize pharmacologically active metabolites including phenylpropanoid glycosides, iridoids, flavonoids, saponins and terpenes from solvent-extracted plant tissue. Samples are selected based on a plant's ethnobotanical history and/or its phylogenetic proximity to species rich in biologically-active phytochemicals. Metabolites are chromatographically purified, spectroscopically characterized and screened for biological activity based on bacterial and cancer cytotoxicity assays. Marine Natural Product Chemistry Marine ecosystems cover nearly seventy percent of the earth's surface and are estimated to contain over eighty percent of world's plant and animal species. Researchers, in collaboration with the National Research Centre in Egypt collect and chemically characterize secondary metabolites produced by marine organisms within the Red Sea; this aquatic environment is considered an epicenter for marine biodiversity due to its extremely high endemic biota. Since constituents from higher plants, along with metabolites from terrestrial microorganisms have provided a substantial fraction of the natural-product-derived drugs currently used in Western medicine, it is expected that the number and diversity of natural products will be vastly expand by the mining of marine organisms.

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Elmasri WA, Hegazy MEF, Mechrefa Y, Pare PW (2015) Cytotoxic saponin poliusaposide from Teucrium polium RSC ADVANCES 5: 27126-27133 Abdel-Rahman RF, Alqasoumi SI, El-Desoky AH, Solimand GA, Paré PW, Hegazy MEF (2015) Evaluation of the anti-inflammatory, analgesic and anti-ulcerogenic potentials of Achillea fragrantissima (Forssk.) SOUTH AFRICAN JOURNAL OF BOTANY 98: 122–127 Elmasri WA, Yang T, Tran P, Hegazy MEF, Hamood AN, Mechref Y, Paré PW (2015) Teucrium polium phenylethanol andiridoid glycoside characterization and flavonoid inhibition of biofilm-forming Staphylococcus aureus. J NATURAL PRODUCTS 78, 2−9 Han QQ, Lü XP, Bai JP, Qiao Y, Paré P W, Wang SM, Zhang JL, Wu YN, Pang XP, Xu WB, Wang ZL (2014) Beneficial soil bacterium Bacillus subtilis (GB03) augments salt tolerance of white clover. FRONT PLANT SCI 5:525 Elmasri W, Hegazy MEF, Aziz M, Koksal E, Amor W, Mechref Y, Hamood AN, Cordes DB, Paré PW (2014) Biofilm blocking sesquiterpenes from Teucrium polium. PHYTOCHEMISTRY 103: 107-113. Hegazy MEF, H Matsuda, S Nakamura, TA Hussein, M Yoshikawa, Paré PW (2014) Chemical constituents and their antibacterial and antifungal activity from the Egyptian herbal medicine Chiliadenus montanus PHYTOCHEMISTRY 103: 154-161 Zhang JL, Aziz M, Qiao Y, Han QQ, Li J, Wang YQ, Shen X, Wang SM, Paré PW (2014) Soil microbe Bacillus subtilis (GB03) induces biomass accumulation and salt tolerance with lower sodium accumulation in wheat. CROP AND PASTURE SCIENCE 65: 423-427 Elkhateeb A, El Beih AA, Gamal Eldeen AM, Alhammady MA, Ohta S, Paré PW, Hegazy MEF (2014) New terpenes from the Egyptian soft coral Sarcophyton ehrenbergi. MARINE DRUGS 12: 1977-1986 Hegazy MEF, Moustfa AY, Mohamed AEH, Alhammady MA, Elbehairi SEI, Ohta S, Paré PW (2014) New cytotoxic halogenated sesquiterpenes from the Egyptian sea hare, Aplysia oculifera. TETRAHEDRON LETTER 55: 1711-1714 Farag M, Paré PW (2013) Phytochemical analysis and anti-inflammatory potential of Hyphaene thebaica L. fruit. J. FOOD SCIENCE 78: 1503-1508 Hagazy M, Mohamed T, Paré PW(2013) Trochelioid A and B, new cembranoid diterpenes from the Red Sea soft coral Sarcophyton trocheliophorum. PHYTOCHEM LETTER 6: 383-386 Hegazy MEF, Gamal-Eldeen AM, El-Halawany AM, Mohamed AEH, Paré PW (2012) Steroidal metabolites transformed by Marchantia polymorpha cultures block breast cancer estrogen biosynthesis. CELL BIOCHEM AND BIOPHYS 63: 85-96 Hegazy MEF, Gamal Eldeen AM, Shahat AA, Abdel-Latif FF, Mohamed TA, Whittlesey BR, Paré PW (2012) Bioactive hydroperoxyl cembranoids from the Red Sea soft coral Sarcophyton glaucum. MARINE DRUGS 10: 209-222 Hegazy MEF, El-Beih AA, Moustafa AY, Hamdy AA, Alhammady MA, Selim RM, Rehim MA, Paré PW (2011) Cytotoxic Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum. NATURAL PRODUCT COMMUNICATIONS 6: 1809-1812 Medeiros FHV, Souza RM, Medeiros FCL, Zhang H, Wheeler T, Payton P, Ferro HM, Paré PW (2011) Transcriptional profiling in cotton associated with Bacillus subtilis (UFLA285) induced biotic-stress tolerance. PLANT SOIL 347: 327-337 Hegazy MEF, Mohamed AHH, Halawany AM, Djemgou, PC, Shahat AA, Paré PW (2011) Estrogenic Activity of Chemical Constituents from Tephrosia candida. JOURNAL NATURAL PRODUCTS 74: 937-942 Zhang H, Murzello C, Sun Y, Kim MS, Xie X, Jeter RM, Zak JC, Dowd SE, Paré PW (2010) Choline and osmotic-stress tolerance induced in Arabidopsis by the soil microbe Bacillus subtilis (GB03). MOLECULAR PLANT-MICROBE INTERACTIONS 23: 1097–1104 Haridy MSA, Hegazy M-EF, Mohamed AE-HH, Paré PW, Hirata T (2010)Biotransformation of progesterone by cultured cells of Marchantia polymorpha. Z. NATURFORSCH: A JOURNAL OF BIOSCIENCES C 65: 599-602 Baek D, Pathange P, Chung JS, Jiang, J, Gao, L, Oikawa A, Hirai MY, Saito K, Paré PW, Shi H (2010) A stress-induced sulphotransferase sulphonates salicylic acid and confers pathogen resistance in Arabidopis. PLANT, CELL & ENVIRONMENT 33: 1383-1392 Rudrappa T, Biedrzychi ML, Kunjeti SG, Donofrio NM, Czymmek KJ, Paré PW, Bais HP (2010) The rhizobacterial elicitor acetoin induces systemic resistance in Arabidopsis thaliana. COMMUNICATIVE & INTEGRATIVE BIOLOGY 3: 130-138