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B.A. Harvard College Biochemistry and Molecular Biology M.D. Harvard Medical School Medicine

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Reduced in vivo toxicity of doxorubicin by encapsulation in cholesterol-containing self-assembled nanoparticles.Gonzalez-Fajardo, Laura; Mahajan, Lalit H; Ndaya, Dennis; Hargrove, Derek; Manautou, José E; Liang, Bruce T; Chen, Ming-Hui; Kasi, Rajeswari M; Lu, Xiuling Pharmacological research 2016 Mar;10793-101 Dsp rul: a spontaneous mouse mutation in desmoplakin as a model of Carvajal-Huerta syndrome.Herbert Pratt, C; Potter, Christopher S; Fairfield, Heather; Reinholdt, Laura G; Bergstrom, David E; Harris, Belinda S; Greenstein, Ian; Dadras, Soheil S; Liang, Bruce T; Schofield, Paul N; Sundberg, John P Experimental and molecular pathology 2015 Feb;98(2):164-72 Cardiac P2X purinergic receptors as a new pathway for increasing Na? entry in cardiac myocytes.Shen, Jian-Bing; Yang, Ronghua; Pappano, Achilles; Liang, Bruce T American journal of physiology. Heart and circulatory physiology 2014 Sep;307(10):H1469-77 Novel protective role of endogenous cardiac myocyte P2X4 receptors in heart failure.Yang, Tiehong; Shen, Jian-bing; Yang, Ronghua; Redden, John; Dodge-Kafka, Kimberly; Grady, James; Jacobson, Kenneth A; Liang, Bruce T Circulation. Heart failure 2014 Mar;7(3):510-8 CD13 is essential for inflammatory trafficking and infarct healing following permanent coronary artery occlusion in mice.Pereira, Flavia E; Cronin, Chunxia; Ghosh, Mallika; Zhou, Si-Yuan; Agosto, Mariela; Subramani, Jaganathan; Wang, Ruibo; Shen, Jian-Bing; Schacke, Wolfgang; Liang, Brannen; Yang, Tie Hong; McAulliffe, Beata; Liang, Bruce T; Shapiro, Linda H Cardiovascular research 2013 Oct;100(1):74-83 The therapeutic effect of 2-cyclohexylthio-AMP in heart failure.Zhou, Siyuan; Yang, Tiehong; Jacobson, Kenneth A; Liang, Bruce T Journal of cardiovascular pharmacology 2013 Jun;61(6):553-9 5'-Phosphate and 5'-phosphonate ester derivatives of (N)-methanocarba adenosine with in vivo cardioprotective activity.Kumar, T Santhosh; Yang, Tiehong; Mishra, Shilpi; Cronin, Chunxia; Chakraborty, Saibal; Shen, Jian-Bing; Liang, Bruce T; Jacobson, Kenneth A Journal of medicinal chemistry 2013 Feb;56(3):902-14 Elevated vascular endothelial growth factor receptor-2 abundance contributes to increased angiogenesis in vascular endothelial growth factor receptor-1-deficient mice.Ho, Vivienne C; Duan, Li-Juan; Cronin, Chunxia; Liang, Bruce T; Fong, Guo-Hua Circulation 2012 Aug;126(6):741-52 Cardiac P2X(4) receptors: targets in ischemia and heart failure?Yang, Ronghua; Liang, Bruce T Circulation research 2012 Aug;111(4):397-401 The clinical impact of circulating caspase-3 p17 level: a potential new biomarker for myocardial injury and cardiovascular disease.Singh, Kanwar P; Jaffe, Allan S; Liang, Bruce T Future cardiology 2011 Jul;7(4):443-5 Adenosine A(3) receptor stimulation induces protection of skeletal muscle from eccentric exercise-mediated injury.Wang, Ruibo; Urso, Maria L; Zambraski, Edward J; Rader, Erik P; Campbell, Kevin P; Liang, Bruce T American journal of physiology. Regulatory, integrative and comparative physiology 2010 Jul;299(1):R259-67 Treatment of heart failure by a methanocarba derivative of adenosine monophosphate: implication for a role of cardiac purinergic P2X receptors.Zhou, Si-Yuan; Mamdani, Mohammed; Qanud, Khaled; Shen, Jian-Bing; Pappano, Achilles J; Kumar, T Santhosh; Jacobson, Kenneth A; Hintze, Thomas; Recchia, Fabio A; Liang, Bruce T The Journal of pharmacology and experimental therapeutics 2010 Jun;333(3):920-8 Structure-activity relationship of (N)-Methanocarba phosphonate analogues of 5'-AMP as cardioprotective agents acting through a cardiac P2X receptor.Kumar, T Santhosh; Zhou, Si-Yuan; Joshi, Bhalchandra V; Balasubramanian, Ramachandran; Yang, Tiehong; Liang, Bruce T; Jacobson, Kenneth A Journal of medicinal chemistry 2010 Mar;53(6):2562-76 TRPM7-mediated Ca2+ signals confer fibrogenesis in human atrial fibrillation.Du, Jianyang; Xie, Jia; Zhang, Zheng; Tsujikawa, Hiroto; Fusco, Daniel; Silverman, David; Liang, Bruce; Yue, Lixia Circulation research 2010 Mar;106(5):992-1003 Reversal of cardiac myocyte dysfunction as a unique mechanism of rescue by P2X4 receptors in cardiomyopathy.Shen, Jian-Bing; Shutt, Robin; Agosto, Mariela; Pappano, Achilles; Liang, Bruce T American journal of physiology. Heart and circulatory physiology 2009 Apr;296(4):H1089-95 Role of P2X purinergic receptors in the rescue of ischemic heart failure.Sonin, Dmitry; Zhou, Si-Yuan; Cronin, Chunxia; Sonina, Tatiana; Wu, Jeffrey; Jacobson, Kenneth A; Pappano, Achilles; Liang, Bruce T American journal of physiology. Heart and circulatory physiology 2008 Sep;295(3):H1191-H1197 Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation.Mamedova, Liaman K; Wang, Ruibo; Besada, Pedro; Liang, Bruce T; Jacobson, Kenneth A Pharmacological research 2008 Jan;58(3-4):232-9 Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injury.Zheng, Jingang; Wang, Rubio; Zambraski, Edward; Wu, Dan; Jacobson, Kenneth A; Liang, Bruce T American journal of physiology. Heart and circulatory physiology 2007 Dec;293(6):H3685-91 Characterization and mechanism of P2X receptor-mediated increase in cardiac myocyte contractility.Shen, Jian-Bing; Shutt, Robin; Pappano, Achilles; Liang, Bruce T American journal of physiology. Heart and circulatory physiology 2007 Nov;293(5):H3056-62 Neoceptors: reengineering GPCRs to recognize tailored ligands.Jacobson, Kenneth A; Gao, Zhan-Guo; Liang, Bruce T Trends in pharmacological sciences 2007 Mar;28(3):111-6 P2X purinergic receptor-mediated ionic current in cardiac myocytes of calsequestrin model of cardiomyopathy: implications for the treatment of heart failure.Shen, Jian-Bing; Cronin, Chunxia; Sonin, Dmitry; Joshi, Bhalchandra V; Gongora Nieto, Maria; Harrison, David; Jacobson, Kenneth A; Liang, Bruce T American journal of physiology. Heart and circulatory physiology 2007 Feb;292(2):H1077-84 Orthogonal activation of the reengineered A3 adenosine receptor (neoceptor) using tailored nucleoside agonists.Gao, Zhan-Guo; Duong, Heng T; Sonina, Tatiana; Kim, Soo-Kyung; Van Rompaey, Philippe; Van Calenbergh, Serge; Mamedova, Liaman; Kim, Hea Ok; Kim, Myong Jung; Kim, Ae Yil; Liang, Bruce T; Jeong, Lak Shin; Jacobson, Kenneth A Journal of medicinal chemistry 2006 May;49(9):2689-702 Extracellular ATP-stimulated current in wild-type and P2X4 receptor transgenic mouse ventricular myocytes: implications for a cardiac physiologic role of P2X4 receptors.Shen, Jian-Bing; Pappano, Achilles J; Liang, Bruce T FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Feb;20(2):277-84 Semi-rational design of (north)-methanocarba nucleosides as dual acting A(1) and A(3) adenosine receptor agonists: novel prototypes for cardioprotection.Jacobson, Kenneth A; Gao, Zhan-Guo; Tchilibon, Susanna; Duong, Heng T; Joshi, Bhalchandra V; Sonin, Dmitry; Liang, Bruce T Journal of medicinal chemistry 2005 Dec;48(26):8103-7

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