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Enhanced gene targeting to evaluate Lynch syndrome alterations.Fishel, Richard; Heinen, Christopher D Proceedings of the National Academy of Sciences of the United States of America 2016 Mar;
Mismatch repair defects and Lynch syndrome: The role of the basic scientist in the battle against cancer.Heinen, Christopher D DNA repair 2015 Dec;
Milestones of Lynch syndrome: 1895-2015.Lynch, Henry T; Snyder, Carrie L; Shaw, Trudy G; Heinen, Christopher D; Hitchins, Megan P Nature reviews. Cancer 2015 Mar;15(3):181-94
Human pluripotent stem cells have a novel mismatch repair-dependent damage response.Lin, Bo; Gupta, Dipika; Heinen, Christopher D The Journal of biological chemistry 2014 Jul;289(35):24314-24
Translating mismatch repair mechanism into cancer care.Heinen, Christopher D Current drug targets 2014 Jan;15(1):53-64
Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database.Thompson, Bryony A; Spurdle, Amanda B; Plazzer, John-Paul; Greenblatt, Marc S; Akagi, Kiwamu; Al-Mulla, Fahd; Bapat, Bharati; Bernstein, Inge; Capellá, Gabriel; den Dunnen, Johan T; du Sart, Desiree; Fabre, Aurelie; Farrell, Michael P; Farrington, Susan M; Frayling, Ian M; Frebourg, Thierry; Goldgar, David E; Heinen, Christopher D; Holinski-Feder, Elke; Kohonen-Corish, Maija; Robinson, Kristina Lagerstedt; Leung, Suet Yi; Martins, Alexandra; Moller, Pal; Morak, Monika; Nystrom, Minna; Peltomaki, Paivi; Pineda, Marta; Qi, Ming; Ramesar, Rajkumar; Rasmussen, Lene Juel; Royer-Pokora, Brigitte; Scott, Rodney J; Sijmons, Rolf; Tavtigian, Sean V; Tops, Carli M; Weber, Thomas; Wijnen, Juul; Woods, Michael O; Macrae, Finlay; Genuardi, Maurizio; Thompson, Bryony A; Spurdle, Amanda B; Plazzer, John-Paul; Greenblatt, Marc S; Akagi, Kiwamu; Al-Mulla, Fahd; Bapat, Bharati; Bernstein, Inge; Capellá, Gabriel; den Dunnen, Johan T; du Sart, Desiree; Fabre, Aurelie; Farrell, Michael P; Farrington, Susan M; Frayling, Ian M; Frebourg, Thierry; Goldgar, David E; Heinen, Christopher D; Holinski-Feder, Elke; Kohonen-Corish, Maija; Robinson, Kristina Lagerstedt; Leung, Suet Yi; Martins, Alexandra; Moller, Pal; Morak, Monika; Nystrom, Minna; Peltomaki, Paivi; Pineda, Marta; Qi, Ming; Ramesar, Rajkumar; Rasmussen, Lene Juel; Royer-Pokora, Brigitte; Scott, Rodney J; Sijmons, Rolf; Tavtigian, Sean V; Tops, Carli M; Weber, Thomas; Wijnen, Juul; Woods, Michael O; Macrae, Finlay; Genuardi, Maurizio; Castillejo, Adela; Sexton, Adrienne; Chan, Anthony K W; Viel, Alessandra; Blanco, Amie; French, Amy; Laner, Andreas; Wagner, Anja; van den Ouweland, Ans; Mensenkamp, Arjen; Payá, Artemio; Betz, Beate; Redeker, Bert; Smith, Betsy; Espenschied, Carin; Cummings, Carole; Engel, Christoph; Fornes, Claudia; Valenzuela, Cristian; Alenda, Cristina; Buchanan, Daniel; Barana, Daniela; Konstantinova, Darina; Cairns, Dianne; Glaser, Elizabeth; Silva, Felipe; Lalloo, Fiona; Crucianelli, Francesca; Hogervorst, Frans; Casey, Graham; Tomlinson, Ian; Blanco, Ignacio; Villar, Isabel López; Garcia-Planells, Javier; Bigler, Jeanette; Shia, Jinru; Martinez-Lopez, Joaquin; Gille, Johan J P; Hopper, John; Potter, John; Soto, José Luis; Kantelinen, Jukka; Ellis, Kate; Mann, Kirsty; Varesco, Liliana; Zhang, Liying; Le Marchand, Loic; Marafie, Makia J; Nordling, Margareta; Tibiletti, Maria Grazia; Kahan, Mariano Ariel; Ligtenberg, Marjolijn; Clendenning, Mark; Jenkins, Mark; Speevak, Marsha; Digweed, Martin; Kloor, Matthias; Hitchins, Megan; Myers, Megan; Aronson, Melyssa; Valentin, Mev Dominguez; Kutsche, Michael; Parsons, Michael; Walsh, Michael; Kansikas, Minttu; Zahary, Mohd Nizam; Pedroni, Monica; Heider, Nao; Poplawski, Nicola; Rahner, Nils; Lindor, Noralane M; Sala, Paola; Nan, Peng; Propping, Peter; Newcomb, Polly; Sarin, Rajiv; Haile, Robert; Hofstra, Robert; Ward, Robyn; Tricarico, Rossella; Bacares, Ruben; Young, Sean; Chialina, Sergio; Kovalenko, Serguei; Gunawardena, Shanaka R; Moreno, Sira; Ho, Siu Lun; Yuen, Siu Tsan; Thibodeau, Stephen N; Gallinger, Steve; Burnett, Terrilea; Teitsch, Therese; Chan, Tsun Leung; Smyrk, Tom; Cranston, Treena; Psofaki, Vasiliki; Steinke-Lange, Verena; Barbera, Victor-Manuel Nature genetics 2013 Dec;46(2):107-15
Response to: Design of a core classification process for DNA mismatch repair variations of a priori unknown functional significance.Rasmussen, Lene Juel; Heinen, Christopher D; Royer-Pokora, Brigitte; Drost, Mark; Tavtigian, Sean; Hofstra, Robert M W; de Wind, Niels Human mutation 2013 Jun;34(6):923-4
Pathological assessment of mismatch repair gene variants in Lynch syndrome: past, present, and future.Rasmussen, Lene Juel; Heinen, Christopher D; Royer-Pokora, Brigitte; Drost, Mark; Tavtigian, Sean; Hofstra, Robert M W; de Wind, Niels Human mutation 2012 Dec;33(12):1617-25
The predicted truncation from a cancer-associated variant of the MSH2 initiation codon alters activity of the MSH2-MSH6 mismatch repair complex.Cyr, Jennifer L; Brown, Graham D; Stroop, Jennifer; Heinen, Christopher D Molecular carcinogenesis 2012 Aug;51(8):647-58
Aberrant crypt foci as predictors of colorectal neoplasia on repeat colonoscopy.Anderson, Joseph C; Swede, Helen; Rustagi, Tarun; Protiva, Petr; Pleau, Devon; Brenner, Bruce M; Rajan, Thiruchandurai V; Heinen, Christopher D; Levine, Joel B; Rosenberg, Daniel W Cancer causes & control : CCC 2012 Feb;23(2):355-61
Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays.Heinen, Christopher D; Juel Rasmussen, Lene Hereditary cancer in clinical practice 2012 Jan;10(1):9
Human MSH2 (hMSH2) protein controls ATP processing by hMSH2-hMSH6.Heinen, Christopher D; Cyr, Jennifer L; Cook, Christopher; Punja, Nidhi; Sakato, Miho; Forties, Robert A; Lopez, Juana Martin; Hingorani, Manju M; Fishel, Richard The Journal of biological chemistry 2011 Nov;286(46):40287-95
Loss of DNA mismatch repair imparts a selective advantage in planarian adult stem cells.Hollenbach, Jessica P; Resch, Alissa M; Palakodeti, Dasaradhi; Graveley, Brenton R; Heinen, Christopher D PloS one 2011 Jan;6(7):e21808
Genotype to phenotype: analyzing the effects of inherited mutations in colorectal cancer families.Heinen, Christopher D Mutation research 2010 Nov;693(1-2):32-45
Lynch syndrome-associated mutations in MSH2 alter DNA repair and checkpoint response functions in vivo.Mastrocola, Adam S; Heinen, Christopher D Human mutation 2010 Oct;31(10):E1699-708
Increased frequency of serrated aberrant crypt foci among smokers.Anderson, Joseph C; Pleau, Devon C; Rajan, Thiruchandurai V; Protiva, Petr; Swede, Helen; Brenner, Bruce; Heinen, Christopher D; Lambrecht, Richard W; Rosenberg, Daniel W The American journal of gastroenterology 2010 Jul;105(7):1648-54
Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage.Mastrocola, Adam S; Heinen, Christopher D DNA repair 2010 Feb;9(2):120-33
Hereditary cancer-associated missense mutations in hMSH6 uncouple ATP hydrolysis from DNA mismatch binding.Cyr, Jennifer L; Heinen, Christopher D The Journal of biological chemistry 2008 Nov;283(46):31641-8
Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer.Stevens, Richard G; Swede, Helen; Heinen, Christopher D; Jablonski, Melissa; Grupka, Michael; Ross, Barry; Parente, Melissa; Tirnauer, Jennifer S; Giardina, Charles; Rajan, Thiruchandurai V; Rosenberg, Daniel W; Levine, Joel Cancer letters 2007 Apr;248(2):262-8
Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans.Rosenberg, Daniel W; Yang, Shi; Pleau, Devon C; Greenspan, Emily J; Stevens, Richard G; Rajan, Thiruchandurai V; Heinen, Christopher D; Levine, Joel; Zhou, Yijian; O'Brien, Michael J Cancer research 2007 Apr;67(8):3551-4
Microsatellite instability in aberrant crypt foci from patients without concurrent colon cancer.Greenspan, Emily J; Cyr, Jennifer L; Pleau, Devon C; Levine, Joel; Rajan, Thiruchandurai V; Rosenberg, Daniel W; Heinen, Christopher D Carcinogenesis 2007 Apr;28(4):769-76
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